U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fbxl12 F-box and leucine-rich repeat protein 12 [ Mus musculus (house mouse) ]

Gene ID: 30843, updated on 8-Dec-2022

Summary

Go to the top of the page Help
Official Symbol
Fbxl12provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 12provided by MGI
Primary source
MGI:MGI:1354738
See related
Ensembl:ENSMUSG00000066892 AllianceGenome:MGI:1354738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbl12; 3110048D16Rik
Summary
Acts upstream of or within ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of ubiquitin ligase complex. Is expressed in chorioallantoic placenta and decidua. Orthologous to human FBXL12 (F-box and leucine rich repeat protein 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 77.7), spleen adult (RPKM 18.9) and 21 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fbxl12 in Genome Data Viewer
Location:
9; 9 A3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20549045..20556064, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20637749..20644768, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51704 Neighboring gene zinc finger protein 846 Neighboring gene F-box and leucine-rich repeat protein 12, opposite strand Neighboring gene ubiquitin-like 5 Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Neighboring gene olfactomedin 2 Neighboring gene predicted gene, 39299

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. FBXL12 regulates T-cell differentiation in a cell-autonomous manner. Nita A, et al. Genes Cells, 2016 May. PMID 26999371
  2. Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. Mallampalli RK, et al. Cell Signal, 2013 Oct. PMID 23707388, Free PMC Article
  3. FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. Nishiyama M, et al. Stem Cells, 2015 Nov. PMID 26124079
  4. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
  5. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article

See all (24) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
F-box/LRR-repeat protein 12
Names
F-box protein FBL12
F-box protein containing leucine repeats 12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002846.2 → NP_001002846.1  F-box/LRR-repeat protein 12 isoform b

    See identical proteins and their annotated locations for NP_001002846.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform b, which has a shorter N-terminus, compared to isoform a. Variants 2 and 4 encode the same protein.
    Source sequence(s)
    AK011081, AK030910, AK031262
    Consensus CDS
    CCDS22881.1
    UniProtKB/Swiss-Prot
    Q9EPX5
    UniProtKB/TrEMBL
    A0A0R4J1Q8
    Related
    ENSMUSP00000083649.4, ENSMUST00000086458.10
    Conserved Domains (2) summary
    cd09293
    Location:68 → 173
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:51 → 72
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. NM_001286529.1 → NP_001273458.1  F-box/LRR-repeat protein 12 isoform c

    See identical proteins and their annotated locations for NP_001273458.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' structure and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform c, which has a longer and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK011081, AK030910, AK031262, DN176232
    Consensus CDS
    CCDS90505.1
    UniProtKB/Swiss-Prot
    Q9EPX5
    UniProtKB/TrEMBL
    A0A0R4J1W2
    Related
    ENSMUSP00000121429.3, ENSMUST00000151861.9
    Conserved Domains (3) summary
    cd09293
    Location:144 → 249
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:127 → 148
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:51 → 73
    F-box-like; F-box-like

  3. NM_001286530.1 → NP_001273459.1  F-box/LRR-repeat protein 12 isoform b

    See identical proteins and their annotated locations for NP_001273459.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform b, which has a shorter N-terminus, compared to isoform a. Variants 2 and 4 encode the same protein.
    Source sequence(s)
    AK030910, AK031262, DN176232
    Consensus CDS
    CCDS22881.1
    UniProtKB/Swiss-Prot
    Q9EPX5
    UniProtKB/TrEMBL
    A0A0R4J1Q8
    Related
    ENSMUSP00000114466.3, ENSMUST00000140702.3
    Conserved Domains (2) summary
    cd09293
    Location:68 → 173
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:51 → 72
    LRR_AMN1; leucine-rich repeat [structural motif]

  4. NM_013911.3 → NP_038939.2  F-box/LRR-repeat protein 12 isoform a

    See identical proteins and their annotated locations for NP_038939.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AC164565, AF313405, AI430452, AK030910, AK031262
    Consensus CDS
    CCDS22880.1
    UniProtKB/Swiss-Prot
    Q9EPX5, Q9QZN5
    Related
    ENSMUSP00000083650.5, ENSMUST00000086459.6
    Conserved Domains (3) summary
    cd09293
    Location:121 → 226
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:104 → 125
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:4 → 48
    F-box-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20549045..20556064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510398.3 → XP_006510461.1  F-box/LRR-repeat protein 12 isoform X2

    See identical proteins and their annotated locations for XP_006510461.1

    UniProtKB/Swiss-Prot
    Q9EPX5
    UniProtKB/TrEMBL
    A0A0R4J1Q8
    Conserved Domains (2) summary
    cd09293
    Location:68 → 173
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:51 → 72
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. XM_006510397.3 → XP_006510460.1  F-box/LRR-repeat protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006510460.1

    UniProtKB/Swiss-Prot
    Q9EPX5, Q9QZN5
    Related
    ENSMUSP00000119124.2, ENSMUST00000148631.8
    Conserved Domains (3) summary
    cd09293
    Location:121 → 226
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:104 → 125
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:4 → 48
    F-box-like

  3. XM_006510399.3 → XP_006510462.1  F-box/LRR-repeat protein 12 isoform X2

    See identical proteins and their annotated locations for XP_006510462.1

    UniProtKB/Swiss-Prot
    Q9EPX5
    UniProtKB/TrEMBL
    A0A0R4J1Q8
    Conserved Domains (2) summary
    cd09293
    Location:68 → 173
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:51 → 72
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPX5.1 GenPept UniProtKB/Swiss-Prot:Q9EPX5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous