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Klhdc8b kelch domain containing 8B [ Rattus norvegicus (Norway rat) ]

Gene ID: 306589, updated on 17-Aug-2024

Summary

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Official Symbol
Klhdc8bprovided by RGD
Official Full Name
kelch domain containing 8Bprovided by RGD
Primary source
RGD:1359445
See related
EnsemblRapid:ENSRNOG00000047867 AllianceGenome:RGD:1359445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in mitotic cytokinetic process; mitotic nuclear division; and nuclear chromosome segregation. Predicted to be located in several cellular components, including cellularization cleavage furrow; intercellular bridge; and midbody. Human ortholog(s) of this gene implicated in Hodgkin's lymphoma. Orthologous to human KLHDC8B (kelch domain containing 8B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 96.7), Uterus (RPKM 67.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhdc8b in Genome Data Viewer
Location:
8q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118020136..118025102, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109141594..109146584, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117232047..117236792, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene interactor of HORMAD1 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene similar to human chromosome 3 open reading frame 84 Neighboring gene coiled-coil domain containing 71 Neighboring gene laminin subunit beta 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitotic errors, aneuploidy and micronuclei in Hodgkin lymphoma pathogenesis. Krem MM, et al. Commun Integr Biol, 2013 May 1. PMID 23713010, Free PMC Article
  2. The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability. Krem MM, et al. J Biol Chem, 2012 Nov 9. PMID 22988245, Free PMC Article
  3. Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma. Krem MM, et al. Cell Cycle, 2010 Feb 15. PMID 20107318, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94736

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mitotic cytokinetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nuclear chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellularization cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellularization cleavage furrow IEA
Inferred from Electronic Annotation
more info
  
located_in cellularization cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cellularization cleavage furrow ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in intercellular bridge IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
kelch domain-containing protein 8B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007685.1 → NP_001007686.1  kelch domain-containing protein 8B

    See identical proteins and their annotated locations for NP_001007686.1

    Status: VALIDATED

    Source sequence(s)
    BC083777
    UniProtKB/Swiss-Prot
    Q5XIA9
    UniProtKB/TrEMBL
    A6I356
    Related
    ENSRNOP00000095128.2, ENSRNOT00000101706.2
    Conserved Domains (2) summary
    PHA03098
    Location:9 → 210
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:69 → 113
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    118020136..118025102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265323.1 → XP_063121393.1  kelch domain-containing protein 8B isoform X1

    UniProtKB/TrEMBL
    A0A8I6B214

  2. XM_039081332.2 → XP_038937260.1  kelch domain-containing protein 8B isoform X2

    Conserved Domains (2) summary
    PHA03098
    Location:2 → 209
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:39 → 81
    Kelch; KELCH repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIA9.1 GenPept UniProtKB/Swiss-Prot:Q5XIA9

Gene LinkOut

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