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Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor [ Mus musculus (house mouse) ]

Gene ID: 30052, updated on 1-Mar-2024

Summary

Official Symbol
Pcsk1nprovided by MGI
Official Full Name
proprotein convertase subtilisin/kexin type 1 inhibitorprovided by MGI
Primary source
MGI:MGI:1353431
See related
Ensembl:ENSMUSG00000039278 AllianceGenome:MGI:1353431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KEP; PEN; Pan3; SAAS; bLEN; lLEN; PEN19; PEN20; SAASCT; proSAAS
Summary
Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within peptide hormone processing; response to cold; and response to dietary excess. Located in extracellular space; secretory granule; and trans-Golgi network. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 181.9), cerebellum adult (RPKM 139.1) and 9 other tissues See more
Orthologs
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Genomic context

See Pcsk1n in Genome Data Viewer
Location:
X A1.1; X 3.57 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7786061..7790649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7919822..7924410)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7684 Neighboring gene polyglutamine binding protein 1 Neighboring gene translocase of inner mitochondrial membrane 17b Neighboring gene STARR-seq mESC enhancer starr_46677 Neighboring gene ES cell-expressed Ras Neighboring gene histone deacetylase 6 Neighboring gene STARR-seq mESC enhancer starr_46678 Neighboring gene STARR-seq mESC enhancer starr_46679 Neighboring gene predicted gene, 39488 Neighboring gene proteasome (prosome, macropain) subunit, beta type 6, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC19107

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proSAAS
Names
IA-4
basic protein IA-4
big PEN LEN
big SAAS
granin-like neuroendocrine peptide
little LEN
little SAAS
pancreas protein 3
pro-SAAS
proprotein convertase 1 inhibitor
protein serine alanine alanine serine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013892.3NP_038920.2  proSAAS precursor

    See identical proteins and their annotated locations for NP_038920.2

    Status: VALIDATED

    Source sequence(s)
    AK002969, AK076137, AL670169, BE986911
    Consensus CDS
    CCDS29979.1
    UniProtKB/Swiss-Prot
    Q91W26, Q9QXV0
    Related
    ENSMUSP00000040342.4, ENSMUST00000041096.4
    Conserved Domains (1) summary
    pfam07259
    Location:1188
    ProSAAS; ProSAAS precursor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7786061..7790649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)