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TLX3 T cell leukemia homeobox 3 [ Homo sapiens (human) ]

Gene ID: 30012, updated on 9-Jun-2025
Official Symbol
TLX3provided by HGNC
Official Full Name
T cell leukemia homeobox 3provided by HGNC
Primary source
HGNC:HGNC:13532
See related
Ensembl:ENSG00000164438 MIM:604640; AllianceGenome:HGNC:13532
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNX; HOX11L2
Summary
The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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See TLX3 in Genome Data Viewer
Location:
5q35.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (171309248..171312139)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (171849588..171852477)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (170736252..170739143)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RAN binding protein 17 Neighboring gene uncharacterized LOC124901217 Neighboring gene USP12 pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:170720541-170721740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170734859-170735743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170735744-170736629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170736630-170737514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170737515-170738400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170740171-170741055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170743669-170744244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170744245-170744819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170744820-170745394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170745395-170745969 Neighboring gene RNA, 7SL, cytoplasmic 339, pseudogene Neighboring gene ribosomal protein L19 pseudogene 10

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2018-09-25)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2018-09-25)

ClinGen Genome Curation Page
Products Interactant Other Gene Complex Source Pubs Description

Clone Names

  • MGC29804

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
T-cell leukemia homeobox protein 3
Names
homeo box 11-like 2
homeobox protein Hox-11L2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021025.4NP_066305.2  T-cell leukemia homeobox protein 3

    See identical proteins and their annotated locations for NP_066305.2

    Status: REVIEWED

    Source sequence(s)
    AC091980, BC017291
    Consensus CDS
    CCDS34288.1
    UniProtKB/Swiss-Prot
    O43711, Q96AD3
    Related
    ENSP00000296921.5, ENST00000296921.6
    Conserved Domains (1) summary
    pfam00046
    Location:169223
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    171309248..171312139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    171849588..171852477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)