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NOP53 NOP53 ribosome biogenesis factor [ Homo sapiens (human) ]

Gene ID: 29997, updated on 9-Feb-2020

Summary

Official Symbol
NOP53provided by HGNC
Official Full Name
NOP53 ribosome biogenesis factorprovided by HGNC
Primary source
HGNC:HGNC:4333
See related
Ensembl:ENSG00000105373 MIM:605691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PICT1; PICT-1; GLTSCR2
Expression
Ubiquitous expression in ovary (RPKM 175.8), spleen (RPKM 136.0) and 25 other tissues See more
Orthologs

Genomic context

See NOP53 in Genome Data Viewer
Location:
19q13.33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (47745546..47757058)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48248793..48260323)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene BRD4 interacting chromatin remodeling complex associated protein Neighboring gene EH domain containing 2 Neighboring gene NOP53 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 23 Neighboring gene selenoprotein W Neighboring gene ribosomal protein L23a pseudogene 80

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5S rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
5S rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic G2 DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein K63-linked deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to nucleolus IEA
Inferred from Electronic Annotation
more info
 
protein localization to nucleoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of aerobic respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with rDNA heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribosome biogenesis protein NOP53
Names
glioma tumor suppressor candidate region gene 2 protein
p60
protein interacting with carboxyl terminus 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015710.5NP_056525.2  ribosome biogenesis protein NOP53

    See identical proteins and their annotated locations for NP_056525.2

    Status: VALIDATED

    Source sequence(s)
    BC004229, BC006311, CX866974
    Consensus CDS
    CCDS12705.1
    UniProtKB/Swiss-Prot
    Q9NZM5
    Related
    ENSP00000246802.4, ENST00000246802.10
    Conserved Domains (1) summary
    pfam07767
    Location:59445
    Nop53; Nop53 (60S ribosomal biogenesis)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    47745546..47757058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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