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SLC39A3 solute carrier family 39 member 3 [ Homo sapiens (human) ]

Gene ID: 29985, updated on 27-Nov-2024

Summary

Official Symbol
SLC39A3provided by HGNC
Official Full Name
solute carrier family 39 member 3provided by HGNC
Primary source
HGNC:HGNC:17128
See related
Ensembl:ENSG00000141873 MIM:612168; AllianceGenome:HGNC:17128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIP3; ZIP-3
Summary
Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Predicted to act upstream of or within several processes, including T cell homeostasis; chordate embryonic development; and zinc ion transport. Predicted to be located in hippocampal mossy fiber to CA3 synapse. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 7.9), brain (RPKM 4.5) and 25 other tissues See more
Orthologs
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Genomic context

See SLC39A3 in Genome Data Viewer
Location:
19p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2732524..2740076, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2707810..2715362, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2732522..2740074, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2643435-2643934 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2650512-2650687 Neighboring gene microRNA 7850 Neighboring gene GNG7 intron CAGE-defined B cell enhancer Neighboring gene MPRA-validated peak3237 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2678080-2678228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2723575-2724487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2734868-2735368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2735369-2735869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9805 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13716 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2739111-2739378 Neighboring gene DIRAS family GTPase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9807 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2768763-2769263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2786765-2787291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2787292-2787818 Neighboring gene small glutamine rich tetratricopeptide repeat co-chaperone alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2796022-2796522 Neighboring gene thimet oligopeptidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic cranial skeleton morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in limb development IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in zinc ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in zinc ion transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in hippocampal mossy fiber to CA3 synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc transporter ZIP3
Names
ZRT/IRT-like protein 3
solute carrier family 39 (zinc transporter), member 3
zinc transporter 3
zrt- and Irt-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144564.5NP_653165.2  zinc transporter ZIP3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC005869, BQ898834
    Consensus CDS
    CCDS12093.1
    UniProtKB/Swiss-Prot
    B3KMJ3, Q8WUG1, Q9BRY0
    UniProtKB/TrEMBL
    F5H385
    Related
    ENSP00000269740.3, ENST00000269740.9
    Conserved Domains (1) summary
    pfam02535
    Location:5309
    Zip; ZIP Zinc transporter
  2. NM_213568.2NP_998733.1  zinc transporter ZIP3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) skips an alternate splice site compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC006538
    Consensus CDS
    CCDS45909.1
    UniProtKB/Swiss-Prot
    Q9BRY0
    Related
    ENSP00000393715.1, ENST00000455372.2
    Conserved Domains (1) summary
    cl00437
    Location:569
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    2732524..2740076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    2707810..2715362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)