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SLC39A3 solute carrier family 39 member 3 [ Homo sapiens (human) ]

Gene ID: 29985, updated on 17-Jun-2019

Summary

Official Symbol
SLC39A3provided by HGNC
Official Full Name
solute carrier family 39 member 3provided by HGNC
Primary source
HGNC:HGNC:17128
See related
Ensembl:ENSG00000141873 MIM:612168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIP3; ZIP-3
Expression
Broad expression in testis (RPKM 7.9), brain (RPKM 4.5) and 25 other tissues See more
Orthologs

Genomic context

See SLC39A3 in Genome Data Viewer
Location:
19p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (2732524..2740076, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2729925..2740074, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 7 Neighboring gene GNG7 intron CAGE-defined B cell enhancer Neighboring gene DIRAS family GTPase 1 Neighboring gene small glutamine rich tetratricopeptide repeat containing alpha Neighboring gene thimet oligopeptidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic cranial skeleton morphogenesis IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
limb development IEA
Inferred from Electronic Annotation
more info
 
zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc transporter ZIP3
Names
solute carrier family 39 (zinc transporter), member 3
zrt- and Irt-like protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144564.5NP_653165.2  zinc transporter ZIP3 isoform a

    See identical proteins and their annotated locations for NP_653165.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC005869, BQ898834
    Consensus CDS
    CCDS12093.1
    UniProtKB/Swiss-Prot
    Q9BRY0
    Related
    ENSP00000269740.3, ENST00000269740.9
    Conserved Domains (1) summary
    pfam02535
    Location:5309
    Zip; ZIP Zinc transporter
  2. NM_213568.2NP_998733.1  zinc transporter ZIP3 isoform b

    See identical proteins and their annotated locations for NP_998733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) skips an alternate splice site compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC006538
    Consensus CDS
    CCDS45909.1
    UniProtKB/Swiss-Prot
    Q9BRY0
    Related
    ENSP00000393715.1, ENST00000455372.2
    Conserved Domains (1) summary
    cl00437
    Location:569
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    2732524..2740076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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