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STRN3 striatin 3 [ Homo sapiens (human) ]

Gene ID: 29966, updated on 7-Aug-2021

Summary

Official Symbol
STRN3provided by HGNC
Official Full Name
striatin 3provided by HGNC
Primary source
HGNC:HGNC:15720
See related
Ensembl:ENSG00000196792 MIM:614766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SG2NA; S/G2NA; PPP2R6B
Expression
Ubiquitous expression in testis (RPKM 11.4), fat (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

See STRN3 in Genome Data Viewer
Location:
14q12
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (30893804..31026401, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31363010..31495585, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27 pseudogene 1 Neighboring gene uncharacterized LOC100506071 Neighboring gene cochlin Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 17 Neighboring gene intraflagellar transport 20 homolog (Chlamydomonas) pseudogene Neighboring gene microRNA 624 Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene HECT domain E3 ubiquitin protein ligase 1 Neighboring gene ribosomal protein L21 pseudogene 5 Neighboring gene RNA, U6 small nuclear 541, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables armadillo repeat domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables armadillo repeat domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 2A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase 2A binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of intracellular estrogen receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
striatin-3
Names
cell cycle S/G2 nuclear autoantigen
cell cycle autoantigen SG2NA
nuclear autoantigen
protein phosphatase 2 regulatory subunit B'''beta
s/G2 antigen
striatin, calmodulin binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083893.2NP_001077362.1  striatin-3 isoform 1

    See identical proteins and their annotated locations for NP_001077362.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), also known as the beta isoform.
    Source sequence(s)
    AA572712, AF243424, AL049830, BC132673, DA854600
    Consensus CDS
    CCDS41938.1
    UniProtKB/Swiss-Prot
    Q13033
    Related
    ENSP00000350071.5, ENST00000357479.10
    Conserved Domains (4) summary
    COG2319
    Location:473790
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:475796
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64190
    Striatin; Striatin family
    sd00039
    Location:485531
    7WD40; WD40 repeat [structural motif]
  2. NM_014574.4NP_055389.3  striatin-3 isoform 2

    See identical proteins and their annotated locations for NP_055389.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 2, also known as the alpha isoform), compared to isoform 1.
    Source sequence(s)
    AA572712, AL049830, BC132673, DA854600
    Consensus CDS
    CCDS9641.1
    UniProtKB/Swiss-Prot
    Q13033
    Related
    ENSP00000347909.5, ENST00000355683.9
    Conserved Domains (3) summary
    cd00200
    Location:391712
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:401447
    7WD40; WD40 repeat [structural motif]
    pfam08232
    Location:65190
    Striatin; Striatin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    30893804..31026401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267569.4XP_005267626.1  striatin-3 isoform X1

    Conserved Domains (4) summary
    COG2319
    Location:436753
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:438759
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64190
    Striatin; Striatin family
    sd00039
    Location:448494
    7WD40; WD40 repeat [structural motif]
  2. XM_005267570.4XP_005267627.1  striatin-3 isoform X2

    Conserved Domains (4) summary
    COG2319
    Location:426743
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:428749
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64190
    Striatin; Striatin family
    sd00039
    Location:438484
    7WD40; WD40 repeat [structural motif]
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