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DPP7 dipeptidyl peptidase 7 [ Homo sapiens (human) ]

Gene ID: 29952, updated on 5-Jul-2020

Summary

Official Symbol
DPP7provided by HGNC
Official Full Name
dipeptidyl peptidase 7provided by HGNC
Primary source
HGNC:HGNC:14892
See related
Ensembl:ENSG00000176978 MIM:610537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QPP; DPP2; DPPII
Summary
The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 29.2), testis (RPKM 27.1) and 25 other tissues See more
Orthologs

Genomic context

See DPP7 in Genome Data Viewer
Location:
9q34.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (137110540..137117980, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140004992..140009204, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene MAN1B1 divergent transcript Neighboring gene mannosidase alpha class 1B member 1 Neighboring gene uncharacterized LOC101930307 Neighboring gene glutamate ionotropic receptor NMDA type subunit 1 Neighboring gene uncharacterized LOC105376328 Neighboring gene microRNA 3621 Neighboring gene leucine rich repeat containing 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
neutrophil degranulation TAS
Traceable Author Statement
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dipeptidyl peptidase 2
Names
DPP II
carboxytripeptidase
dipeptidyl aminopeptidase II
dipeptidyl arylamidase II
dipeptidyl-peptidase II
quiescent cell proline dipeptidase
NP_037511.2
XP_005266132.1
XP_006717146.1
XP_011516901.1
XP_011516902.1
XP_016870140.1
XP_016870141.1
XP_024303293.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013379.3NP_037511.2  dipeptidyl peptidase 2 preproprotein

    See identical proteins and their annotated locations for NP_037511.2

    Status: REVIEWED

    Source sequence(s)
    AF154502, AL533195, BC016961, BX400716
    Consensus CDS
    CCDS7030.1
    UniProtKB/Swiss-Prot
    Q9UHL4
    Related
    ENSP00000360635.2, ENST00000371579.7
    Conserved Domains (1) summary
    cl21494
    Location:38465
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    137110540..137117980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518600.1XP_011516902.1  dipeptidyl peptidase 2 isoform X4

    Conserved Domains (1) summary
    cl21494
    Location:56457
    Abhydrolase; alpha/beta hydrolases
  2. XM_017014651.1XP_016870140.1  dipeptidyl peptidase 2 isoform X5

  3. XM_011518599.2XP_011516901.1  dipeptidyl peptidase 2 isoform X2

    Conserved Domains (1) summary
    cl21494
    Location:86487
    Abhydrolase; alpha/beta hydrolases
  4. XM_024447525.1XP_024303293.1  dipeptidyl peptidase 2 isoform X7

    Conserved Domains (1) summary
    cl21494
    Location:166319
    Abhydrolase; alpha/beta hydrolases
  5. XM_017014652.2XP_016870141.1  dipeptidyl peptidase 2 isoform X6

  6. XM_006717083.4XP_006717146.1  dipeptidyl peptidase 2 isoform X3

    Conserved Domains (1) summary
    cl21494
    Location:38449
    Abhydrolase; alpha/beta hydrolases
  7. XM_005266075.4XP_005266132.1  dipeptidyl peptidase 2 isoform X1

    Conserved Domains (1) summary
    cl21494
    Location:38538
    Abhydrolase; alpha/beta hydrolases
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