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DPP7 dipeptidyl peptidase 7 [ Homo sapiens (human) ]

Gene ID: 29952, updated on 2-Nov-2024

Summary

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Official Symbol
DPP7provided by HGNC
Official Full Name
dipeptidyl peptidase 7provided by HGNC
Primary source
HGNC:HGNC:14892
See related
Ensembl:ENSG00000176978 MIM:610537; AllianceGenome:HGNC:14892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QPP; DPP2; DPPII
Summary
The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 29.2), testis (RPKM 27.1) and 25 other tissues See more
Orthologs
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Genomic context

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See DPP7 in Genome Data Viewer
Location:
9q34.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137110546..137118306, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149348484..149356230, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140004998..140009185, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene mannosidase alpha class 1B member 1 Neighboring gene small nucleolar RNA SNORD62 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29344 Neighboring gene uncharacterized LOC124902313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20581 Neighboring gene uncharacterized LOC124902314 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20583 Neighboring gene Sharpr-MPRA regulatory region 8071 Neighboring gene glutamate ionotropic receptor NMDA type subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29346 Neighboring gene uncharacterized LOC105376328

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effect of cholesterol and its autooxidation derivatives on endocytosis and dipeptidyl peptidases of aortic endothelial cells. Fornas E, et al. Histol Histopathol, 1992 Apr. PMID 1515698
  2. Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase. Underwood R, et al. J Biol Chem, 1999 Nov 26. PMID 10567372
  3. Peptidases play an important role in cataractogenesis: an immunohistochemical study on lenses derived from Shumiya cataract rats. Zhan H, et al. Histochem J, 2001 Sep-Oct. PMID 12005022
  4. A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. Chiravuri M, et al. J Immunol, 1999 Sep 15. PMID 10477574
  5. Design of (omega-N-(O-acyl)hydroxy amid) aminodicarboxylic acid pyrrolidides as potent inhibitors of proline-specific peptidases. Demuth HU, et al. FEBS Lett, 1993 Mar 29. PMID 8096464

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. human DPP7 structures reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases
    Title: Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases.
  2. The constitutive expression of dipeptidyl peptidase II mRNA in chronic lymphocytic leukemia was demonstrated.
    Title: Expression and prognostic assessment of dipeptidyl peptidase IV and related enzymes in B-cell chronic lymphocytic leukemia.
  3. DPP2 is essential for maintaining lymphocytes and fibroblasts in G(0), and its inhibition results in apoptosis mediated by induction of c-Myc and p53.
    Title: Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence.
  4. DPP II plays a minor role in the progression of malignant melanocytic lesions
    Title: Dipeptidyl peptidase II is not a marker for progression in melanoma.
  5. catalytic properties and inhibition of this proline-specific enzyme
    Title: Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in lysosomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dipeptidyl peptidase 2
Names
DPP II
carboxytripeptidase
dipeptidyl aminopeptidase II
dipeptidyl arylamidase II
dipeptidyl-peptidase II
quiescent cell proline dipeptidase
NP_037511.2
XP_011516901.1
XP_011516902.1
XP_016870140.1
XP_016870141.1
XP_047279236.1
XP_047279237.1
XP_054218802.1
XP_054218803.1
XP_054218804.1
XP_054218805.1
XP_054218806.1
XP_054218807.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013379.3 → NP_037511.2  dipeptidyl peptidase 2 preproprotein

    See identical proteins and their annotated locations for NP_037511.2

    Status: REVIEWED

    Source sequence(s)
    AF154502, AL533195, BC016961, BX400716
    Consensus CDS
    CCDS7030.1
    UniProtKB/Swiss-Prot
    A8K7U7, Q5VSF1, Q969X4, Q9UHL4
    Related
    ENSP00000360635.2, ENST00000371579.7
    Conserved Domains (1) summary
    cl21494
    Location:38 → 465
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    137110546..137118306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423281.1 → XP_047279237.1  dipeptidyl peptidase 2 isoform X6

  2. XM_011518600.2 → XP_011516902.1  dipeptidyl peptidase 2 isoform X2

    Related
    ENST00000706880.1
    Conserved Domains (1) summary
    cl21494
    Location:56 → 457
    Abhydrolase; alpha/beta hydrolases

  3. XM_017014652.3 → XP_016870141.1  dipeptidyl peptidase 2 isoform X5

    Related
    ENSP00000520771.1, ENST00000718334.1

  4. XM_017014651.2 → XP_016870140.1  dipeptidyl peptidase 2 isoform X3

  5. XM_011518599.3 → XP_011516901.1  dipeptidyl peptidase 2 isoform X1

    Related
    ENST00000478597.6
    Conserved Domains (1) summary
    cl21494
    Location:86 → 487
    Abhydrolase; alpha/beta hydrolases

  6. XM_047423280.1 → XP_047279236.1  dipeptidyl peptidase 2 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    149348484..149356230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362832.1 → XP_054218807.1  dipeptidyl peptidase 2 isoform X6

  2. XM_054362828.1 → XP_054218803.1  dipeptidyl peptidase 2 isoform X2

  3. XM_054362827.1 → XP_054218802.1  dipeptidyl peptidase 2 isoform X1

  4. XM_054362829.1 → XP_054218804.1  dipeptidyl peptidase 2 isoform X3

  5. XM_054362830.1 → XP_054218805.1  dipeptidyl peptidase 2 isoform X4

  6. XM_054362831.1 → XP_054218806.1  dipeptidyl peptidase 2 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UHL4.3 GenPept UniProtKB/Swiss-Prot:Q9UHL4

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