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HCFC2 host cell factor C2 [ Homo sapiens (human) ]

Gene ID: 29915, updated on 6-Nov-2022

Summary

Official Symbol
HCFC2provided by HGNC
Official Full Name
host cell factor C2provided by HGNC
Primary source
HGNC:HGNC:24972
See related
Ensembl:ENSG00000111727 MIM:607926; AllianceGenome:HGNC:24972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCF2; HCF-2
Summary
This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 10.0), endometrium (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

See HCFC2 in Genome Data Viewer
Location:
12q23.3
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (104064531..104106524)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (104026224..104068218)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104458309..104500302)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene thymine DNA glycosylase Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene phosphoglycerate mutase 1 (brain) pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 370 Neighboring gene nuclear transcription factor Y subunit beta Neighboring gene uncharacterized LOC105369947

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ94012

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of MLL1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of MLL1/2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of Set1C/COMPASS complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
part_of histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
host cell factor 2
Names
C2 factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013320.3NP_037452.1  host cell factor 2

    See identical proteins and their annotated locations for NP_037452.1

    Status: REVIEWED

    Source sequence(s)
    AC089983, AI247087, BC033799, DB030069
    Consensus CDS
    CCDS9097.1
    UniProtKB/Swiss-Prot
    C0H5X3, Q9Y5Z7
    Related
    ENSP00000229330.4, ENST00000229330.9
    Conserved Domains (5) summary
    PLN02193
    Location:2262
    PLN02193; nitrile-specifier protein
    cd00063
    Location:618672
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00038
    Location:190241
    Kelch; KELCH repeat [structural motif]
    pfam13415
    Location:207253
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:312354
    Kelch_5; Kelch motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    104064531..104106524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428753.1XP_047284709.1  host cell factor 2 isoform X2

  2. XM_017019242.3XP_016874731.1  host cell factor 2 isoform X1

  3. XM_047428754.1XP_047284710.1  host cell factor 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    104026224..104068218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)