Format

Send to:

Choose Destination

Sav1 salvador family WW domain containing protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299116, updated on 3-Oct-2018

Summary

Official Symbol
Sav1provided by RGD
Official Full Name
salvador family WW domain containing protein 1provided by RGD
Primary source
RGD:1307253
See related
Ensembl:ENSRNOG00000005264
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Lung (RPKM 256.9), Muscle (RPKM 226.2) and 9 other tissues See more
Orthologs

Genomic context

See Sav1 in Genome Data Viewer
Location:
6q24
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (92376470..92398678, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (101825584..101846408, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5 Neighboring gene atlastin GTPase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein R-like Neighboring gene similar to SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 Neighboring gene ninein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex scaffold activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
hair follicle development ISO
Inferred from Sequence Orthology
more info
 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling ISO
Inferred from Sequence Orthology
more info
 
hippo signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
intestinal epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
intestinal epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
lung epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lung epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
regulation of organ growth ISO
Inferred from Sequence Orthology
more info
 
regulation of stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein salvador homolog 1
Names
45 kDa WW domain protein
Salvador homolog 1 protein
rWW45

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097581.1NP_001091050.1  protein salvador homolog 1

    See identical proteins and their annotated locations for NP_001091050.1

    Status: PROVISIONAL

    Source sequence(s)
    AM261215
    UniProtKB/Swiss-Prot
    A4V8B4
    UniProtKB/TrEMBL
    B1WBL9
    Related
    ENSRNOP00000007314.4, ENSRNOT00000007314.6
    Conserved Domains (1) summary
    cd00201
    Location:204234
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    92376470..92398678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    86974336..86994740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center