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EEF2K eukaryotic elongation factor 2 kinase [ Homo sapiens (human) ]

Gene ID: 29904, updated on 22-May-2020

Summary

Official Symbol
EEF2Kprovided by HGNC
Official Full Name
eukaryotic elongation factor 2 kinaseprovided by HGNC
Primary source
HGNC:HGNC:24615
See related
Ensembl:ENSG00000103319 MIM:606968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
eEF-2K; CaMKIII; HSU93850
Summary
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 21.4), fat (RPKM 10.0) and 24 other tissues See more
Orthologs

Genomic context

See EEF2K in Genome Data Viewer
Location:
16p12.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (22206278..22288738)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22217592..22300066)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 42E, member 2 Neighboring gene tRNA-Leu (anticodon TAG) 3-1 Neighboring gene GATA motif-containing MPRA enhancer 198 Neighboring gene tRNA-Leu (anticodon AAG) 2-4 Neighboring gene RNA polymerase III subunit E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45041

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
elongation factor-2 kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
translation factor activity, RNA binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to anoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to brain-derived neurotrophic factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
response to ischemia IEA
Inferred from Electronic Annotation
more info
 
response to prolactin IEA
Inferred from Electronic Annotation
more info
 
translational elongation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic elongation factor 2 kinase
Names
alternative protein EEF2K
calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase
calmodulin-dependent protein kinase III
eEF-2 kinase
elongation factor-2 kinase
eukaroytic elongation factor 2 kinase
XP_016878682.1
XP_016878683.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013302.5NP_037434.2  eukaryotic elongation factor 2 kinase

    Status: REVIEWED

    Source sequence(s)
    AC009034
    Consensus CDS
    CCDS10604.1
    Related
    ENSP00000263026.5, ENST00000263026.10

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    22206278..22288738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023194.2XP_016878683.1  eukaryotic elongation factor 2 kinase isoform X2

  2. XM_017023193.2XP_016878682.1  eukaryotic elongation factor 2 kinase isoform X1

    UniProtKB/Swiss-Prot
    O00418
    Conserved Domains (3) summary
    smart00811
    Location:121318
    Alpha_kinase; Alpha-kinase family
    COG0790
    Location:533713
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:547576
    SLR; SLR repeat [structural motif]

RNA

  1. XR_001751897.2 RNA Sequence

  2. XR_950786.3 RNA Sequence

  3. XR_950787.3 RNA Sequence

    Related
    ENST00000568269.5

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p13 PATCHES

    Range
    816312..898761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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