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MYL11 myosin light chain 11 [ Homo sapiens (human) ]

Gene ID: 29895, updated on 11-Jun-2025
Official Symbol
MYL11provided by HGNC
Official Full Name
myosin light chain 11provided by HGNC
Primary source
HGNC:HGNC:29824
See related
Ensembl:ENSG00000180209 MIM:617378; AllianceGenome:HGNC:29824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DA1C; MLC2B; MRLC2; MYLPF; HUMMLC2B
Summary
Predicted to enable calcium ion binding activity. Predicted to be a structural constituent of muscle. Involved in muscle contraction. Located in lysosomal membrane. Implicated in distal arthrogryposis type 1C. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in prostate (RPKM 32.5) and esophagus (RPKM 15.3) See more
Orthologs
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See MYL11 in Genome Data Viewer
Location:
16p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30370934..30377991)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30757137..30764194)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30382255..30389312)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:30365679-30366878 Neighboring gene CD2 cytoplasmic tail binding protein 2 Neighboring gene CD2BP2 divergent transcript Neighboring gene TBC1 domain family member 10B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7364 Neighboring gene Sharpr-MPRA regulatory region 9884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30390133-30390690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30390691-30391248 Neighboring gene septin 1 Neighboring gene zinc finger protein 48 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30404661-30405161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30407163-30407759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30410094-30410637 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30418651-30418830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7369 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7370 Neighboring gene zinc finger protein 771 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7371 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7373

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC13450, DKFZp779C0757

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of muscle IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of muscle ISS
Inferred from Sequence or Structural Similarity
more info
 
enables structural constituent of muscle TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin-myosin filament sliding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle tissue morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in skeletal muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in lysosomal membrane HDA PubMed 
part_of muscle myosin complex TAS
Traceable Author Statement
more info
PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
myosin regulatory light chain 11
Names
fast skeletal myosin light chain 2
myosin light chain 2
myosin light chain, phosphorylatable, fast skeletal muscle
myosin, light chain 11, regulatory

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050592.1 RefSeqGene

    Range
    8869..12058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001324458.2NP_001311387.1  myosin regulatory light chain 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) and variants 1 and 3 all encode the same protein.
    Source sequence(s)
    AA662706, AC127457, BC012571, BI837593
    Consensus CDS
    CCDS10677.1
    UniProtKB/Swiss-Prot
    A0A024QZG6, B2RA83, Q14843, Q6IB41, Q96A32
    UniProtKB/TrEMBL
    H3BPK4
    Conserved Domains (1) summary
    COG5126
    Location:15154
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_001324459.2NP_001311388.1  myosin regulatory light chain 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) and variants 1 and 2 all encode the same protein.
    Source sequence(s)
    AA662706, BC012571, BI828249
    Consensus CDS
    CCDS10677.1
    UniProtKB/Swiss-Prot
    A0A024QZG6, B2RA83, Q14843, Q6IB41, Q96A32
    UniProtKB/TrEMBL
    H3BPK4
    Conserved Domains (1) summary
    COG5126
    Location:15154
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  3. NM_013292.5NP_037424.2  myosin regulatory light chain 11

    See identical proteins and their annotated locations for NP_037424.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the predominant variant. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AA662706, AK314082
    Consensus CDS
    CCDS10677.1
    UniProtKB/Swiss-Prot
    A0A024QZG6, B2RA83, Q14843, Q6IB41, Q96A32
    UniProtKB/TrEMBL
    H3BPK4
    Related
    ENSP00000325239.7, ENST00000322861.12
    Conserved Domains (1) summary
    COG5126
    Location:15154
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    30370934..30377991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    30757137..30764194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)