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CNOT7 CCR4-NOT transcription complex subunit 7 [ Homo sapiens (human) ]

Gene ID: 29883, updated on 6-Jan-2019

Summary

Official Symbol
CNOT7provided by HGNC
Official Full Name
CCR4-NOT transcription complex subunit 7provided by HGNC
Primary source
HGNC:HGNC:14101
See related
Ensembl:ENSG00000198791 MIM:604913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAF1; CAF-1; Caf1a; hCAF-1
Summary
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.7) and 25 other tissues See more
Orthologs

Genomic context

See CNOT7 in Genome Data Viewer
Location:
8p22
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (17221981..17246909, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17086737..17104387, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986918 Neighboring gene ribosomal protein L9 pseudogene 20 Neighboring gene zinc finger DHHC-type containing 2 Neighboring gene VPS37A, ESCRT-I subunit Neighboring gene myotubularin related protein 7 Neighboring gene uncharacterized LOC102724838 Neighboring gene ADAM metallopeptidase domain 24, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Deadenylation of mRNA, organism-specific biosystem (from REACTOME)
    Deadenylation of mRNA, organism-specific biosystemDeadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 compl...
  • Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
    Deadenylation-dependent mRNA decay, organism-specific biosystemAfter undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystemUnder a variety of stress conditions, TP53 (p53), stabilized by stress-induced phosphorylation at least on S15 and S20 serine residues, can induce the transcription of genes involved in cell cycle ar...
  • TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, organism-specific biosystem (from REACTOME)
    TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, organism-specific biosystemBTG2 is induced by TP53, leading to cessation of cellular proliferation (Rouault et al. 1996, Duriez et al. 2002). BTG2 binds to the CCR4-NOT complex and promotes mRNA deadenylation activity of this ...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly(A)-specific ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic mRNA processing body assembly IEA
Inferred from Electronic Annotation
more info
 
deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
Inferred from Electronic Annotation
more info
 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by RNA ISS
Inferred from Sequence or Structural Similarity
more info
 
gene silencing by miRNA TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear-transcribed mRNA poly(A) tail shortening TAS
Traceable Author Statement
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
CCR4-NOT complex NAS
Non-traceable Author Statement
more info
PubMed 
CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
P-body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
host cell PML body IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane HDA PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear speck IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 7
Names
BTG1-binding factor 1
CCR4-associated factor 1
carbon catabolite repressor protein (CCR4)-associative factor 1
NP_001309016.1
NP_001309017.1
NP_001309018.1
NP_001309019.1
NP_001309020.1
NP_001309021.1
NP_001309022.1
NP_001309023.1
NP_001309024.1
NP_001309025.1
NP_001309026.1
NP_001309027.1
NP_001309028.1
NP_001309029.1
NP_037486.2
NP_473367.2
XP_005273538.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322087.1NP_001309016.1  CCR4-NOT transcription complex subunit 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
    Source sequence(s)
    AW448990, BC070187, BI094365, BI458088, DA695885, DA752620
    Consensus CDS
    CCDS55202.1
    UniProtKB/Swiss-Prot
    Q9UIV1
    Conserved Domains (1) summary
    cl23804
    Location:1244
    CAF1; CAF1 family ribonuclease
  2. NM_001322088.1NP_001309017.1  CCR4-NOT transcription complex subunit 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
    Source sequence(s)
    AL833642, AW448990, BC070187, BI094365, BI552176, DA695885
    Consensus CDS
    CCDS55202.1
    UniProtKB/Swiss-Prot
    Q9UIV1
    Conserved Domains (1) summary
    cl23804
    Location:1244
    CAF1; CAF1 family ribonuclease
  3. NM_001322089.1NP_001309018.1  CCR4-NOT transcription complex subunit 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
    Source sequence(s)
    AC091050, AW448990, BC070187, BI094365, BI464507, DA695885, HY002876
    Consensus CDS
    CCDS55202.1
    UniProtKB/Swiss-Prot
    Q9UIV1
    Conserved Domains (1) summary
    cl23804
    Location:1244
    CAF1; CAF1 family ribonuclease
  4. NM_001322090.1NP_001309019.1  CCR4-NOT transcription complex subunit 7 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
    Source sequence(s)
    BC007315, BC070187, BI458088, DA752620
    Consensus CDS
    CCDS6000.2
    UniProtKB/Swiss-Prot
    Q9UIV1
    UniProtKB/TrEMBL
    Q96IQ6
    Conserved Domains (1) summary
    cl23804
    Location:1279
    CAF1; CAF1 family ribonuclease
  5. NM_001322091.1NP_001309020.1  CCR4-NOT transcription complex subunit 7 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
    Source sequence(s)
    AL833642, BC007315, BC070187, BI552176
    Consensus CDS
    CCDS6000.2
    UniProtKB/Swiss-Prot
    Q9UIV1
    UniProtKB/TrEMBL
    Q96IQ6
    Conserved Domains (1) summary
    cl23804
    Location:1279
    CAF1; CAF1 family ribonuclease
  6. NM_001322092.1NP_001309021.1  CCR4-NOT transcription complex subunit 7 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
    Source sequence(s)
    AL833642, BC007315, BC070187, BI458088, BI552176
    Consensus CDS
    CCDS6000.2
    UniProtKB/Swiss-Prot
    Q9UIV1
    UniProtKB/TrEMBL
    Q96IQ6
    Conserved Domains (1) summary
    cl23804
    Location:1279
    CAF1; CAF1 family ribonuclease
  7. NM_001322093.1NP_001309022.1  CCR4-NOT transcription complex subunit 7 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains an additional in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.
    Source sequence(s)
    AC091050, BC007315, BC070187, BI464507, DA752620
    UniProtKB/Swiss-Prot
    Q9UIV1
    UniProtKB/TrEMBL
    Q96IQ6
    Conserved Domains (1) summary
    cl23804
    Location:1301
    CAF1; CAF1 family ribonuclease
  8. NM_001322094.1NP_001309023.1  CCR4-NOT transcription complex subunit 7 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate splice site in the 3' terminal exon and thus contains an alternate 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AL528251, BC007315, BC070187, DA752620
    UniProtKB/Swiss-Prot
    Q9UIV1
    UniProtKB/TrEMBL
    Q96IQ6
    Conserved Domains (1) summary
    cl23804
    Location:1245
    CAF1; CAF1 family ribonuclease
  9. NM_001322095.1NP_001309024.1  CCR4-NOT transcription complex subunit 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) contains an additional exon and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
    Source sequence(s)
    BC007315, BC070187, DA508565, DA752620
    UniProtKB/Swiss-Prot
    Q9UIV1
    UniProtKB/TrEMBL
    Q96IQ6
    Conserved Domains (1) summary
    cl23804
    Location:2198
    CAF1; CAF1 family ribonuclease
  10. NM_001322096.1NP_001309025.1  CCR4-NOT transcription complex subunit 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) contains an additional exon and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
    Source sequence(s)
    BC007315, BC070187, DA720240, DA752620
    UniProtKB/Swiss-Prot
    Q9UIV1
    UniProtKB/TrEMBL
    Q96IQ6
    Conserved Domains (1) summary
    cl23804
    Location:2198
    CAF1; CAF1 family ribonuclease
  11. NM_001322097.1NP_001309026.1  CCR4-NOT transcription complex subunit 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) contains alternate 5' exon structure and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
    Source sequence(s)
    AL833642, BC007315, BC070187, BI552176, DA720240
    UniProtKB/Swiss-Prot
    Q9UIV1
    UniProtKB/TrEMBL
    Q96IQ6
    Conserved Domains (1) summary
    cl23804
    Location:2198
    CAF1; CAF1 family ribonuclease
  12. NM_001322098.1NP_001309027.1  CCR4-NOT transcription complex subunit 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) contains an additional exon and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
    Source sequence(s)
    AW448990, BC070187, BI094365, DA508565, DA695885, DA752620
    UniProtKB/Swiss-Prot
    Q9UIV1
    Conserved Domains (1) summary
    cl23804
    Location:2163
    CAF1; CAF1 family ribonuclease
  13. NM_001322099.1NP_001309028.1  CCR4-NOT transcription complex subunit 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) contains an additional exon and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
    Source sequence(s)
    AW448990, BC070187, BI094365, DA695885, DA720240, DA752620
    UniProtKB/Swiss-Prot
    Q9UIV1
    Conserved Domains (1) summary
    cl23804
    Location:2163
    CAF1; CAF1 family ribonuclease
  14. NM_001322100.1NP_001309029.1  CCR4-NOT transcription complex subunit 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
    Source sequence(s)
    AW448990, BC070187, BI094365, BI458088, BI552176, DA508565, DA695885
    UniProtKB/Swiss-Prot
    Q9UIV1
    Conserved Domains (1) summary
    cl23804
    Location:2163
    CAF1; CAF1 family ribonuclease
  15. NM_013354.7NP_037486.2  CCR4-NOT transcription complex subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_037486.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 6, 7 and 8 all encode isoform 1.
    Source sequence(s)
    AC091050, BC007315, BC070187, DA752620
    Consensus CDS
    CCDS6000.2
    UniProtKB/Swiss-Prot
    Q9UIV1
    UniProtKB/TrEMBL
    Q96IQ6
    Related
    ENSP00000355279.4, ENST00000361272.8
    Conserved Domains (1) summary
    cl23804
    Location:1279
    CAF1; CAF1 family ribonuclease
  16. NM_054026.3NP_473367.2  CCR4-NOT transcription complex subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_473367.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
    Source sequence(s)
    AW448990, BC070187, BI094365, DA695885, DA752620
    Consensus CDS
    CCDS55202.1
    UniProtKB/Swiss-Prot
    Q9UIV1
    Related
    ENSP00000429093.1, ENST00000523917.5
    Conserved Domains (1) summary
    cl23804
    Location:1244
    CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    17221981..17246909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273481.3XP_005273538.1  CCR4-NOT transcription complex subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_005273538.1

    UniProtKB/Swiss-Prot
    Q9UIV1
    Conserved Domains (1) summary
    cl23804
    Location:1279
    CAF1; CAF1 family ribonuclease
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