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GUCA2B guanylate cyclase activator 2B [ Homo sapiens (human) ]

Gene ID: 2981, updated on 1-Aug-2020

Summary

Official Symbol
GUCA2Bprovided by HGNC
Official Full Name
guanylate cyclase activator 2Bprovided by HGNC
Primary source
HGNC:HGNC:4683
See related
Ensembl:ENSG00000044012 MIM:601271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UGN; GCAP-II
Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]
Expression
Biased expression in small intestine (RPKM 47.4), colon (RPKM 37.0) and 1 other tissue See more
Orthologs

Genomic context

See GUCA2B in Genome Data Viewer
Location:
1p34.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (42153410..42155820)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (42619092..42621495)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene vir like m6A methyltransferase associated pseudogene Neighboring gene HIVEP zinc finger 3 Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene 1 Neighboring gene guanylate cyclase activator 2A Neighboring gene forkhead box J3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium sensitive guanylate cyclase activator activity TAS
Traceable Author Statement
more info
PubMed 
guanylate cyclase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
body fluid secretion IEA
Inferred from Electronic Annotation
more info
 
cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
digestion TAS
Traceable Author Statement
more info
 
excretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanylate cyclase activator 2B
Names
prepro-uroguanylin
uroguanylin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007102.3NP_009033.1  guanylate cyclase activator 2B preproprotein

    See identical proteins and their annotated locations for NP_009033.1

    Status: VALIDATED

    Source sequence(s)
    AC114492, BC093781, U34279, Z50753
    Consensus CDS
    CCDS464.1
    UniProtKB/Swiss-Prot
    Q16661
    Related
    ENSP00000361662.1, ENST00000372581.2
    Conserved Domains (1) summary
    pfam02058
    Location:27111
    Guanylin; Guanylin precursor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    42153410..42155820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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