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NCAPH2 non-SMC condensin II complex subunit H2 [ Homo sapiens (human) ]

Gene ID: 29781, updated on 22-Sep-2022

Summary

Official Symbol
NCAPH2provided by HGNC
Official Full Name
non-SMC condensin II complex subunit H2provided by HGNC
Primary source
HGNC:HGNC:25071
See related
Ensembl:ENSG00000025770 MIM:611230; AllianceGenome:HGNC:25071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPH2
Summary
This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants.[provided by RefSeq, May 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 17.2), testis (RPKM 13.4) and 25 other tissues See more
Orthologs
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Genomic context

See NCAPH2 in Genome Data Viewer
Location:
22q13.33
Exon count:
22
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50508224..50524780)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (51018752..51035345)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50946653..50963209)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene myo-inositol oxygenase Neighboring gene lipase maturation factor 2 Neighboring gene synthesis of cytochrome C oxidase 2 Neighboring gene thymidine phosphorylase Neighboring gene outer dense fiber of sperm tails 3B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2455, MGC4133, MGC5305, MGC8640, MGC15858, MGC18000

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in condensed nuclear chromosome IC
Inferred by Curator
more info
 
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of condensin complex IC
Inferred by Curator
more info
PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
condensin-2 complex subunit H2
Names
CAP-H2 subunit of the condensin II complex
CTA-384D8.36
chromosome-associated protein H2
kleisin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021419.1 RefSeqGene

    Range
    5009..21565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001185011.2NP_001171940.1  condensin-2 complex subunit H2 isoform 3

    See identical proteins and their annotated locations for NP_001171940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding region, compared to variant 1. The resulting protein (isoform 3) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    BC009441, DB498781, U62317
    Consensus CDS
    CCDS54546.1
    UniProtKB/Swiss-Prot
    Q6IBW4
    Related
    ENSP00000299821.11, ENST00000299821.15
    Conserved Domains (3) summary
    pfam06278
    Location:11123
    CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
    pfam16858
    Location:316588
    CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
    pfam16869
    Location:147252
    CNDH2_M; PF16858
  2. NM_014551.5NP_055366.3  condensin-2 complex subunit H2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC001833, DB498781
    Consensus CDS
    CCDS43038.1
    UniProtKB/Swiss-Prot
    Q6IBW4
    Related
    ENSP00000379050.3, ENST00000395698.7
    Conserved Domains (2) summary
    pfam06278
    Location:11123
    CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
    pfam16869
    Location:147252
    CNDH2_M; PF16858
  3. NM_152299.4NP_689512.2  condensin-2 complex subunit H2 isoform 2

    See identical proteins and their annotated locations for NP_689512.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    BC001937, BC009441, DB498781, U62317
    Consensus CDS
    CCDS14094.2
    UniProtKB/Swiss-Prot
    Q6IBW4, Q9BVD1
    Related
    ENSP00000410088.2, ENST00000420993.7
    Conserved Domains (3) summary
    pfam06278
    Location:11123
    CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
    pfam16858
    Location:316587
    CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
    pfam16869
    Location:147252
    CNDH2_M; PF16858

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    50508224..50524780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261912.5XP_005261969.1  condensin-2 complex subunit H2 isoform X1

    Conserved Domains (3) summary
    pfam06278
    Location:1096
    CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
    pfam16858
    Location:289561
    CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
    pfam16869
    Location:120225
    CNDH2_M; PF16858
  2. XM_017028793.3XP_016884282.1  condensin-2 complex subunit H2 isoform X2

  3. XM_011530685.3XP_011528987.1  condensin-2 complex subunit H2 isoform X3

    Conserved Domains (2) summary
    pfam16858
    Location:136408
    CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
    pfam16869
    Location:172
    CNDH2_M; PF16858
  4. XM_047441352.1XP_047297308.1  condensin-2 complex subunit H2 isoform X4

  5. XM_047441353.1XP_047297309.1  condensin-2 complex subunit H2 isoform X5

  6. XM_047441354.1XP_047297310.1  condensin-2 complex subunit H2 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    51018752..51035345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)