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Uchl1 ubiquitin C-terminal hydrolase L1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29545, updated on 13-Apr-2024

Summary

Official Symbol
Uchl1provided by RGD
Official Full Name
ubiquitin C-terminal hydrolase L1provided by RGD
Primary source
RGD:3928
See related
Ensembl:ENSRNOG00000002343 AllianceGenome:RGD:3928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including alpha-2A adrenergic receptor binding activity; cysteine-type peptidase activity; and ubiquitin protein ligase binding activity. Involved in sensory perception of pain and ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including neuron projection terminus; neuronal cell body; and nucleoplasm. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 1933.6), Testes (RPKM 195.6) and 1 other tissue See more
Orthologs
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Genomic context

See Uchl1 in Genome Data Viewer
Location:
14p11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (41838859..41849743, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (41485031..41495590, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (43133224..43143942, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene LIM and calponin homology domains 1 Neighboring gene uncharacterized LOC120096605 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134481847 Neighboring gene U6 spliceosomal RNA Neighboring gene amyloid beta precursor protein binding family B member 2 Neighboring gene uncharacterized LOC134481846

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-2A adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables omega peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adult walking behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axon target recognition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axonal transport of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within eating behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within male germ cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within muscle cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to ischemia ISO
Inferred from Sequence Orthology
more info
 
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L1
Names
PGP 9.5
PGP9.5
UCH-L1
neuron cytoplasmic protein 9.5
ubiquitin carboxy-terminal hydrolase L1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ubiquitin thioesterase L1
NP_058933.2
XP_063129073.1
XP_063129074.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017237.4NP_058933.2  ubiquitin carboxyl-terminal hydrolase isozyme L1

    See identical proteins and their annotated locations for NP_058933.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q00981, Q6P9V8
    UniProtKB/TrEMBL
    A0A8L2Q0S4, A6JDB5, A6JDB6
    Related
    ENSRNOP00000086461.1, ENSRNOT00000094226.1
    Conserved Domains (1) summary
    cd09616
    Location:5219
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    41838859..41849743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273004.1XP_063129074.1  ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G7R6
  2. XM_063273003.1XP_063129073.1  ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X1