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GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 2953, updated on 1-Jun-2020

Summary

Official Symbol
GSTT2provided by HGNC
Official Full Name
glutathione S-transferase theta 2 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:4642
See related
Ensembl:ENSG00000099984 MIM:600437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]
Expression
Broad expression in adrenal (RPKM 18.4), skin (RPKM 14.6) and 20 other tissues See more
Orthologs

Genomic context

See GSTT2 in Genome Data Viewer
Location:
22q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (23980134..23983915)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24322291..24326106)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase theta 2B Neighboring gene D-dopachrome tautomerase like Neighboring gene D-dopachrome tautomerase Neighboring gene glutathione S-transferase theta 4 Neighboring gene uncharacterized LOC105372959

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC182032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
glutathione S-transferase theta-2
Names
GST class-theta-2
NP_000845.2
NP_001289599.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000854.4NP_000845.2  glutathione S-transferase theta-2 isoform a

    See identical proteins and their annotated locations for NP_000845.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) encodes the longer isoform (a). This variant represents the ALT_REF_LOCI_1 alternate haplotype in the GRCh38 reference genome assembly.
    Source sequence(s)
    AA682380, BM804805, BU584249, CX782167, HY221848
    UniProtKB/Swiss-Prot
    P0CG29
    Conserved Domains (3) summary
    cd03183
    Location:91216
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    COG0625
    Location:14210
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03050
    Location:378
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
  2. NM_001302670.1NP_001289599.1  glutathione S-transferase theta-2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. This variant represents the ALT_REF_LOCI_1 alternate haplotype in the GRCh38 reference genome assembly.
    Source sequence(s)
    AA682380, BM804805, BM976631, BU584249, CX782167
    Conserved Domains (3) summary
    cd03183
    Location:91202
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    COG0625
    Location:14196
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03050
    Location:378
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

RNA

  1. NR_126442.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an additional internal exon and uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant represents the ALT_REF_LOCI_1 alternate haplotype in the GRCh38 reference genome assembly.
    Source sequence(s)
    AA682380, BM804805, BM976631, CD013993, CX782167
  2. NR_126445.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) represents the non-functional and pseudogenic primary reference allele of the GRCh38 reference genome assembly. It differs at three nucleotide positions compared to variant 1, and includes a premature translational stop codon.
    Source sequence(s)
    AC253536
    Related
    ENST00000634759.1
  3. NR_126446.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant represents the ALT_REF_LOCI_1 alternate haplotype in the GRCh38 reference genome assembly.
    Source sequence(s)
    AA682380, BM804805, BM976631, CD013993, CX782167

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    23980134..23983915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    216394..220281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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