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GSTM2 glutathione S-transferase mu 2 [ Homo sapiens (human) ]

Gene ID: 2946, updated on 1-Aug-2020

Summary

Official Symbol
GSTM2provided by HGNC
Official Full Name
glutathione S-transferase mu 2provided by HGNC
Primary source
HGNC:HGNC:4634
See related
Ensembl:ENSG00000213366 MIM:138380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST4; GSTM; GTHMUS; GSTM2-2
Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 68.7), skin (RPKM 43.2) and 25 other tissues See more
Orthologs

Genomic context

See GSTM2 in Genome Data Viewer
Location:
1p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (109668022..109683997)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110210644..110226619)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 8 Neighboring gene glutathione S-transferase mu 4 Neighboring gene glutathione S-transferase mu 1 Neighboring gene glutathione S-transferase mu 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117303

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
fatty acid binding IPI
Inferred from Physical Interaction
more info
PubMed 
glutathione binding IDA
Inferred from Direct Assay
more info
PubMed 
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular detoxification of nitrogen compound IDA
Inferred from Direct Assay
more info
PubMed 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to caffeine IDA
Inferred from Direct Assay
more info
PubMed 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hepoxilin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
nitrobenzene metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC
Inferred by Curator
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IC
Inferred by Curator
more info
PubMed 
relaxation of cardiac muscle TAS
Traceable Author Statement
more info
PubMed 
xenobiotic catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutathione S-transferase Mu 2
Names
GST class-mu 2
GST, muscle
S-(hydroxyalkyl)glutathione lyase M2
epididymis secretory sperm binding protein
glutathione S-alkyltransferase M2
glutathione S-aralkyltransferase M2
glutathione S-aryltransferase M2
glutathione S-transferase 4
glutathione S-transferase M1
glutathione S-transferase M2 (muscle)
glutathione S-transferase mu 2 (muscle)
NP_000839.1
NP_001135840.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000848.4NP_000839.1  glutathione S-transferase Mu 2 isoform 1

    See identical proteins and their annotated locations for NP_000839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    BC105038, BC110380, DA528798
    Consensus CDS
    CCDS808.1
    UniProtKB/Swiss-Prot
    P28161
    UniProtKB/TrEMBL
    Q0D2I8
    Related
    ENSP00000241337.4, ENST00000241337.9
    Conserved Domains (2) summary
    cd03209
    Location:92212
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  2. NM_001142368.1NP_001135840.1  glutathione S-transferase Mu 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC000031, AK299482, BC110380, DA528798
    Consensus CDS
    CCDS44192.1
    UniProtKB/Swiss-Prot
    P28161
    UniProtKB/TrEMBL
    Q0D2I8
    Related
    ENSP00000416883.1, ENST00000442650.5
    Conserved Domains (3) summary
    COG0625
    Location:3189
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    cl02776
    Location:92189
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    109668022..109683997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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