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Capns1 calpain, small subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29156, updated on 2-May-2024

Summary

Symbol
Capns1provided by RGD
Full Name
calpain, small subunit 1provided by RGD
Primary source
RGD:2270
See related
Ensembl:ENSRNOG00000067065 AllianceGenome:RGD:2270
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Capn4
Summary
Contributes to calcium-dependent cysteine-type endopeptidase activity. Involved in proteolysis. Predicted to be located in cytosol and membrane. Orthologous to human CAPNS1 (calpain small subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 558.0), Heart (RPKM 527.5) and 9 other tissues See more
Orthologs
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Genomic context

See Capns1 in Genome Data Viewer
Location:
1q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94572083..94582332, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85444613..85454861, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91058528..91064880, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 146 Neighboring gene prothymosin alpha, pseudogene 5 Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene ribosomal protein S24, pseudogene 2 Neighboring gene U2 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 826

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
contributes_to calcium-dependent cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of calpain complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of calpain complex IEA
Inferred from Electronic Annotation
more info
 
part_of calpain complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calpain small subunit 1
Names
CANP small subunit
CDPS
CSS1
calcium-activated neutral proteinase small subunit
calcium-dependent protease small subunit 1
calpain 4
calpain regulatory subunit
calpain small subunit 1-like
NP_058814.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017118.1NP_058814.1  calpain small subunit 1

    See identical proteins and their annotated locations for NP_058814.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098068
    UniProtKB/Swiss-Prot
    P97572, Q4V795, Q64537
    UniProtKB/TrEMBL
    A6J9U9, M0RD20
    Related
    ENSRNOP00000067513.2, ENSRNOT00000072756.2
    Conserved Domains (1) summary
    cl08302
    Location:146196
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    94572083..94582332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005500363.2 RNA Sequence