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C11orf21 chromosome 11 open reading frame 21 [ Homo sapiens (human) ]

Gene ID: 29125, updated on 11-Jun-2021

Summary

Official Symbol
C11orf21provided by HGNC
Official Full Name
chromosome 11 open reading frame 21provided by HGNC
Primary source
HGNC:HGNC:13231
See related
Ensembl:ENSG00000110665 MIM:611033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in bone marrow (RPKM 16.9), spleen (RPKM 6.5) and 7 other tissues See more
Orthologs
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Genomic context

See C11orf21 in Genome Data Viewer
Location:
11p15.5
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (2295628..2303140, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2316858..2324370, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microRNA 4686 Neighboring gene tyrosine hydroxylase Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene tetraspanin 32 Neighboring gene RNA, U6 small nuclear 878, pseudogene Neighboring gene CD81 antisense RNA 1 Neighboring gene ribosomal protein L26 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uncharacterized protein C11orf21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142946.3NP_001136418.1  uncharacterized protein C11orf21 isoform 1

    See identical proteins and their annotated locations for NP_001136418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB029488, AC129929, AK310172
    Consensus CDS
    CCDS44518.1
    UniProtKB/Swiss-Prot
    Q9P2W6
    UniProtKB/TrEMBL
    E9PAM5
    Related
    ENSP00000406541.2, ENST00000456145.2
    Conserved Domains (1) summary
    pfam15399
    Location:68178
    DUF4620; Domain of unknown function (DUF4620)
  2. NM_001329958.2NP_001316887.1  uncharacterized protein C11orf21 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB029488, AC129929
    Consensus CDS
    CCDS86168.1
    UniProtKB/Swiss-Prot
    Q9P2W6
    Related
    ENSP00000370545.4, ENST00000381153.8
    Conserved Domains (1) summary
    pfam15399
    Location:22132
    DUF4620; Domain of unknown function (DUF4620)

RNA

  1. NR_138249.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC129929, DA941234

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    2295628..2303140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520034.2XP_011518336.1  uncharacterized protein C11orf21 isoform X1

    See identical proteins and their annotated locations for XP_011518336.1

    UniProtKB/TrEMBL
    E9PAM5
    Conserved Domains (1) summary
    pfam15399
    Location:68178
    DUF4620; Domain of unknown function (DUF4620)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014144.1: Suppressed sequence

    Description
    NM_014144.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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