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LGALS13 galectin 13 [ Homo sapiens (human) ]

Gene ID: 29124, updated on 11-Jun-2021

Summary

Official Symbol
LGALS13provided by HGNC
Official Full Name
galectin 13provided by HGNC
Primary source
HGNC:HGNC:15449
See related
Ensembl:ENSG00000105198 MIM:608717
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP13; GAL13; PLAC8
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward placenta (RPKM 6.7) See more
Orthologs
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Genomic context

See LGALS13 in Genome Data Viewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (39602411..39607474)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40093164..40098114)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 pseudogene 25 Neighboring gene ribosomal protein S29 pseudogene 26 Neighboring gene galectin 14 pseudogene Neighboring gene ribosomal protein S29 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of T cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
galactoside-binding soluble lectin 13
Names
beta-galactoside-binding lectin
gal-13
lectin, galactoside-binding, soluble, 13
placental protein 13
placental tissue protein 13
NP_037400.1
XP_011525176.1
XP_016882204.1
XP_024307242.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013268.3NP_037400.1  galactoside-binding soluble lectin 13

    See identical proteins and their annotated locations for NP_037400.1

    Status: REVIEWED

    Source sequence(s)
    AC005205
    Consensus CDS
    CCDS33024.1
    UniProtKB/Swiss-Prot
    Q9UHV8
    Related
    ENSP00000221797.3, ENST00000221797.5
    Conserved Domains (1) summary
    smart00908
    Location:11135
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    39602411..39607474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026715.1XP_016882204.1  galactoside-binding soluble lectin 13 isoform X1

  2. XM_011526874.2XP_011525176.1  galactoside-binding soluble lectin 13 isoform X2

    Conserved Domains (1) summary
    smart00908
    Location:30128
    Gal-bind_lectin; Galactoside-binding lectin
  3. XM_024451474.1XP_024307242.1  galactoside-binding soluble lectin 13 isoform X3

    Conserved Domains (1) summary
    smart00908
    Location:42166
    Gal-bind_lectin; Galactoside-binding lectin
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