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COMMD5 COMM domain containing 5 [ Homo sapiens (human) ]

Gene ID: 28991, updated on 18-Aug-2020

Summary

Official Symbol
COMMD5provided by HGNC
Official Full Name
COMM domain containing 5provided by HGNC
Primary source
HGNC:HGNC:17902
See related
Ensembl:ENSG00000170619 MIM:608216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCARG; HT002
Expression
Ubiquitous expression in bone marrow (RPKM 4.8), spleen (RPKM 4.2) and 25 other tissues See more
Orthologs

Genomic context

See COMMD5 in Genome Data Viewer
Location:
8q24.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144837978..144853556, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (146075551..146078932, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 6850 Neighboring gene ribosomal protein L8 Neighboring gene uncharacterized LOC100130027 Neighboring gene zinc finger protein 517 Neighboring gene zinc finger protein 7 Neighboring gene zinc finger protein 250 Neighboring gene zinc finger protein 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13008, MGC72046

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
COMM domain-containing protein 5
Names
hypertension-related calcium-regulated gene protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081003.3NP_001074472.1  COMM domain-containing protein 5

    See identical proteins and their annotated locations for NP_001074472.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AW137480, BC002672, BI753202, BU600590
    Consensus CDS
    CCDS6436.1
    UniProtKB/Swiss-Prot
    Q9GZQ3
    Related
    ENSP00000394331.2, ENST00000450361.2
    Conserved Domains (1) summary
    cd04753
    Location:115224
    Commd5_HCaRG; COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal ...
  2. NM_001081004.3NP_001074473.1  COMM domain-containing protein 5

    See identical proteins and their annotated locations for NP_001074473.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AW137480, BC002672, BQ680339
    Consensus CDS
    CCDS6436.1
    UniProtKB/Swiss-Prot
    Q9GZQ3
    Related
    ENSP00000385793.3, ENST00000402718.4
    Conserved Domains (1) summary
    cd04753
    Location:115224
    Commd5_HCaRG; COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal ...
  3. NM_001287237.2NP_001274166.1  COMM domain-containing protein 5

    See identical proteins and their annotated locations for NP_001274166.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AW137480, BC003055, BM013651, BQ680339
    Consensus CDS
    CCDS6436.1
    UniProtKB/Swiss-Prot
    Q9GZQ3
    Related
    ENSP00000445840.2, ENST00000543949.2
    Conserved Domains (1) summary
    cd04753
    Location:115224
    Commd5_HCaRG; COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal ...
  4. NM_014066.4NP_054785.2  COMM domain-containing protein 5

    See identical proteins and their annotated locations for NP_054785.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 4. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AW137480, BC065729, BG705627
    Consensus CDS
    CCDS6436.1
    UniProtKB/Swiss-Prot
    Q9GZQ3
    Related
    ENSP00000304544.3, ENST00000305103.4
    Conserved Domains (1) summary
    cd04753
    Location:115224
    Commd5_HCaRG; COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144837978..144853556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002956629.1 RNA Sequence

  2. XR_002956628.1 RNA Sequence

  3. XR_928321.3 RNA Sequence

  4. XR_428379.3 RNA Sequence

  5. XR_928323.3 RNA Sequence

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