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NOB1 NIN1 (RPN12) binding protein 1 homolog [ Homo sapiens (human) ]

Gene ID: 28987, updated on 3-Nov-2024

Summary

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Official Symbol
NOB1provided by HGNC
Official Full Name
NIN1 (RPN12) binding protein 1 homologprovided by HGNC
Primary source
HGNC:HGNC:29540
See related
Ensembl:ENSG00000141101 MIM:613586; AllianceGenome:HGNC:29540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ART-4; NOB1P; MST158; MSTP158; PSMD8BP1
Summary
In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in ovary (RPKM 29.6), thyroid (RPKM 20.5) and 25 other tissues See more
Orthologs
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Genomic context

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See NOB1 in Genome Data Viewer
Location:
16q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (69741871..69754926, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (75544399..75557460, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69775774..69788829, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:69753551-69753732 Neighboring gene small nucleolar RNA, C/D box 13H Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:69760025-69761224 Neighboring gene NAD(P)H quinone dehydrogenase 1 Neighboring gene NQO1 divergent transcript Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:69787875-69788498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:69788499-69789121 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:69796040-69796618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11045 Neighboring gene non-POU domain containing, octamer-binding pseudogene 1 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11047 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:69924551-69925074 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:69950984-69952183 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:69964206-69964363 Neighboring gene microRNA 140

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evaluation of NIN/RPN12 binding protein inhibits proliferation and growth in human renal cancer cells. Jia JW, et al. Tumour Biol, 2015 Mar. PMID 25420906
  2. Expression of the NOB1 gene and its clinical significance in papillary thyroid carcinoma. Lin S, et al. J Int Med Res, 2013 Jun. PMID 23685895
  3. Knockdown of NOB1 expression by RNAi inhibits cellular proliferation and migration in human gliomas. Wang H, et al. Gene, 2013 Oct 10. PMID 23911301
  4. Clinical significance of NOB1 expression in breast infiltrating ductal carcinoma. Li XY, et al. Int J Clin Exp Pathol, 2013. PMID 24133592, Free PMC Article
  5. NOB1 in non-small-cell lung cancer: expression profile and clinical significance. Liu K, et al. Pathol Oncol Res, 2014 Apr. PMID 24272676

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA FEZF1-AS1 aggravates cell proliferation and migration in glioblastoma.
    Title: LncRNA FEZF1-AS1 aggravates cell proliferation and migration in glioblastoma.
  2. Silencing NOB1 Can Affect Cell Proliferation and Apoptosis Via the C-Jun N-Terminal Kinase Pathway in Colorectal Cancer.
    Title: Silencing NOB1 Can Affect Cell Proliferation and Apoptosis Via the C-Jun N-Terminal Kinase Pathway in Colorectal Cancer.
  3. MiR-363 suppresses cell migration, invasion, and epithelial-mesenchymal transition of osteosarcoma by binding to NOB1.
    Title: MiR-363 suppresses cell migration, invasion, and epithelial-mesenchymal transition of osteosarcoma by binding to NOB1.
  4. MicroRNA-139-3p suppresses growth and metastasis of glioblastoma via inhibition of NIN1/RPNI2 binding protein 1 homolog.
    Title: MicroRNA-139-3p suppresses growth and metastasis of glioblastoma via inhibition of NIN1/RPNI2 binding protein 1 homolog.
  5. NOB1: A Potential Biomarker or Target in Cancer.
    Title: NOB1: A Potential Biomarker or Target in Cancer.
  6. NOB1 was correlated with clinical outcomes and prognosis of gastric cancer patients and was an independent risk factor for 5-year mortality of GC patients.
    Title: NOB1 Gene as a Potential Biomarker in Clinical Outcomes and Prognosis of Patients with Gastric Cancer.
  7. A detailed characterization of Nob1 organization and its interaction with Pno1.
    Title: Domain definition and interaction mapping for the endonuclease complex hNob1/hPno1.
  8. These results suggested that RIOK2 and NOB1 may be potential targets in the treatment of Non-small cell lung cancer (NSCLC), and miR145 may be considered a therapeutic inhibitor of both genes.
    Title: miR‑145 inhibits human non‑small-cell lung cancer growth by dual-targeting RIOK2 and NOB1.
  9. our results indicate that miR-330-5p inhibits non-small-cell lung cancer (NSCLC) cell growth through downregulation of NOB1 expression. Our study suggests that miR-330-5p may serve as a potential therapeutic target for the treatment of NSCLC
    Title: Inhibition of NOB1 by microRNA-330-5p overexpression represses cell growth of non-small cell lung cancer.
  10. Authors identified that SNHG1 increased human nin one binding protein (NOB1), an oncogene, through sponging miR-326 as competing endogenous RNA (ceRNA), finally prompting cell growth, migration and invasion in OS.
    Title: Long non-coding RNA SNHG1 regulates NOB1 expression by sponging miR-326 and promotes tumorigenesis in osteosarcoma.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA endonuclease activity EXP
Inferred from Experiment
more info
 PubMed 
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing TAS
Traceable Author Statement
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein NOB1
Names
NIN1/PSMD8 binding protein 1 homolog
PSMD8 binding protein 1
adenocarcinoma antigen recognized by T lymphocytes 4
nin one binding protein
phosphorylation regulatory protein HP-10
protein ART-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014062.3 → NP_054781.1  RNA-binding protein NOB1

    See identical proteins and their annotated locations for NP_054781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AB026125
    Consensus CDS
    CCDS10884.1
    UniProtKB/Swiss-Prot
    Q7L6B7, Q7M4M4, Q7Z4B5, Q9NWB0, Q9ULX3
    UniProtKB/TrEMBL
    B2RAR2
    Related
    ENSP00000268802.5, ENST00000268802.10
    Conserved Domains (3) summary
    cd09876
    Location:7 → 109
    PIN_Nob1-like; VapC-like PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
    pfam08772
    Location:260 → 332
    NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like
    pfam15017
    Location:152 → 212
    WRNPLPNID; Putative WW-binding domain and destruction box

RNA

  1. NR_074074.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC000050, BG386829, BM793847, DA004856, DB048531

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    69741871..69754926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    75544399..75557460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULX3.1 GenPept UniProtKB/Swiss-Prot:Q9ULX3

Gene LinkOut

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