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AAMDC adipogenesis associated Mth938 domain containing [ Homo sapiens (human) ]

Gene ID: 28971, updated on 21-Dec-2019

Summary

Official Symbol
AAMDCprovided by HGNC
Official Full Name
adipogenesis associated Mth938 domain containingprovided by HGNC
Primary source
HGNC:HGNC:30205
See related
Ensembl:ENSG00000087884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CK067; PTD015; C11orf67
Expression
Ubiquitous expression in adrenal (RPKM 14.7), fat (RPKM 11.2) and 24 other tissues See more
Orthologs

Genomic context

See AAMDC in Genome Data Viewer
Location:
11q14.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (77821114..77901281)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77532147..77583398)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene remodeling and spacing factor 1 Neighboring gene ferritin heavy chain 1 pseudogene 16 Neighboring gene ribosomal protein S20 pseudogene 27 Neighboring gene ribosomal protein L21 pseudogene 95 Neighboring gene integrator complex subunit 4 Neighboring gene NDUFC2-KCTD14 readthrough Neighboring gene potassium channel tetramerization domain containing 14 Neighboring gene NADH:ubiquinone oxidoreductase subunit C2 Neighboring gene thyroid hormone responsive

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3367, FLJ21035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mth938 domain-containing protein
Names
UPF0366 protein C11orf67
adipogenesis associated Mth938 domain-containing protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316957.1NP_001303886.1  mth938 domain-containing protein isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF092136, AP002812, BP270361, BX646013, CN362204
    Consensus CDS
    CCDS81605.1
    UniProtKB/Swiss-Prot
    Q9H7C9
    UniProtKB/TrEMBL
    K4DI89
    Related
    ENSP00000307254.8, ENST00000304716.12
    Conserved Domains (1) summary
    cd05126
    Location:593
    Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
  2. NM_001316958.1NP_001303887.1  mth938 domain-containing protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AP002812, BP270361, BX646013, CN362204
    Consensus CDS
    CCDS81604.1
    UniProtKB/TrEMBL
    E9PLK9
    Related
    ENSP00000433281.1, ENST00000527134.5
    Conserved Domains (1) summary
    cl00182
    Location:593
    Mth938-like; Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a ...
  3. NM_001316960.1NP_001303889.1  mth938 domain-containing protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has an alternate exon in place of the last two exons compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a. Variants 3, 4, 5, and 6 all encode the same isoform (c).
    Source sequence(s)
    BC002752, BI791786, BP270361
    Consensus CDS
    CCDS8254.1
    UniProtKB/Swiss-Prot
    Q9H7C9
    Conserved Domains (1) summary
    cd05126
    Location:5120
    Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
  4. NM_001316961.1NP_001303890.1  mth938 domain-containing protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has an alternate exon in place of the last two exons compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a. Variants 3, 4, 5, and 6 all encode the same isoform (c).
    Source sequence(s)
    AI569731, AP002812, BC002752, BP270361
    Consensus CDS
    CCDS8254.1
    UniProtKB/Swiss-Prot
    Q9H7C9
    Conserved Domains (1) summary
    cd05126
    Location:5120
    Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
  5. NM_001316962.1NP_001303891.1  mth938 domain-containing protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an alternate exon in place of the last two exons compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a. Variants 3, 4, 5, and 6 all encode the same isoform (c).
    Source sequence(s)
    BM930331, BP270361
    Consensus CDS
    CCDS8254.1
    UniProtKB/Swiss-Prot
    Q9H7C9
    Related
    ENSP00000431808.1, ENST00000526415.5
    Conserved Domains (1) summary
    cd05126
    Location:5120
    Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
  6. NM_001363564.1NP_001350493.1  mth938 domain-containing protein isoform d

    Status: VALIDATED

    Source sequence(s)
    AP002812
    Consensus CDS
    CCDS86232.1
    Related
    ENSP00000432830.1, ENST00000525034.1
    Conserved Domains (1) summary
    cd05126
    Location:24139
    Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
  7. NM_024684.3NP_078960.1  mth938 domain-containing protein isoform c

    See identical proteins and their annotated locations for NP_078960.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has an alternate exon in place of the last two exons compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a. Variants 3, 4, 5, and 6 all encode the same isoform (c).
    Source sequence(s)
    BC002752, BP270361
    Consensus CDS
    CCDS8254.1
    UniProtKB/Swiss-Prot
    Q9H7C9
    Related
    ENSP00000377078.2, ENST00000393427.6
    Conserved Domains (1) summary
    cd05126
    Location:5120
    Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...

RNA

  1. NR_133637.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate 5' exon and an alternate 3' exon, and contains another alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP002812, BP270361, BX646013
    Related
    ENST00000526164.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    77821114..77901281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544969.2XP_011543271.1  mth938 domain-containing protein isoform X2

    See identical proteins and their annotated locations for XP_011543271.1

    UniProtKB/Swiss-Prot
    Q9H7C9
    Conserved Domains (1) summary
    cd05126
    Location:5120
    Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
  2. XM_017017620.1XP_016873109.1  mth938 domain-containing protein isoform X3

    Conserved Domains (1) summary
    cd05126
    Location:24112
    Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
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