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GRB10 growth factor receptor bound protein 10 [ Homo sapiens (human) ]

Gene ID: 2887, updated on 22-Aug-2021

Summary

Official Symbol
GRB10provided by HGNC
Official Full Name
growth factor receptor bound protein 10provided by HGNC
Primary source
HGNC:HGNC:4564
See related
Ensembl:ENSG00000106070 MIM:601523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSS; IRBP; MEG1; GRB-IR; Grb-10
Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in thyroid (RPKM 6.6), kidney (RPKM 5.7) and 25 other tissues See more
Orthologs
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Genomic context

See GRB10 in Genome Data Viewer
Location:
7p12.1
Exon count:
34
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (50590068..50793453, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (50657765..50861150, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9793 Neighboring gene dopa decarboxylase Neighboring gene DDC antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 14531 Neighboring gene ribosomal protein L39 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genetic locus in 7p12.2 associated with treatment resistant schizophrenia.
GeneReviews: Not available
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
GeneReviews: Not available
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
GeneReviews: Not available
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
GeneReviews: Not available
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
GeneReviews: Not available
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
GeneReviews: Not available

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-03-23)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-03-23)

ClinGen Genome Curation Page

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0207

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor complex adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular associated smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
growth factor receptor-bound protein 10
Names
GRB10 adapter protein
GRB10 adaptor protein
insulin receptor-binding protein Grb-IR
maternally expressed gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012305.2 RefSeqGene

    Range
    5010..208395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1032

mRNA and Protein(s)

  1. NM_001001549.3NP_001001549.1  growth factor receptor-bound protein 10 isoform b

    See identical proteins and their annotated locations for NP_001001549.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as hGrb10alpha, lacks an in-frame segment in the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AC005153, AC080092
    Consensus CDS
    CCDS47586.1
    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000349818.5, ENST00000357271.9
    Conserved Domains (4) summary
    cd01787
    Location:166248
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:441548
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:283362
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:380421
    BPS; BPS (Between PH and SH2)
  2. NM_001001550.3NP_001001550.1  growth factor receptor-bound protein 10 isoform c

    See identical proteins and their annotated locations for NP_001001550.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as hGrb10beta, differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a. Isoform c is encoded by transcript variants 4, 6, and 7.
    Source sequence(s)
    AC005153, AC080092
    Consensus CDS
    CCDS43583.1
    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000381790.2, ENST00000398810.6
    Conserved Domains (4) summary
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:108199
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  3. NM_001001555.3NP_001001555.1  growth factor receptor-bound protein 10 isoform c

    See identical proteins and their annotated locations for NP_001001555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a. Isoform c is encoded by transcript variants 3, 4, 6, and 7.
    Source sequence(s)
    AC004920, AC005153, AC080092
    Consensus CDS
    CCDS43583.1
    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000338543.3, ENST00000335866.7
    Conserved Domains (4) summary
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:108199
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  4. NM_001350814.2NP_001337743.1  growth factor receptor-bound protein 10 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC004920, AC005153, AC080092
    Consensus CDS
    CCDS43582.1
    Related
    ENSP00000385770.1, ENST00000401949.6
    Conserved Domains (4) summary
    cd01787
    Location:166248
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:487594
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:286408
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:426467
    BPS; BPS (Between PH and SH2)
  5. NM_001350815.2NP_001337744.1  growth factor receptor-bound protein 10 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes isoform d.
    Source sequence(s)
    AC004920, AC005153, AC080092
    Consensus CDS
    CCDS87504.1
    Related
    ENSP00000493728.1, ENST00000644879.1
    Conserved Domains (4) summary
    cd01787
    Location:204286
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:525632
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:324446
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:464505
    BPS; BPS (Between PH and SH2)
  6. NM_001350816.3NP_001337745.2  growth factor receptor-bound protein 10 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 3, 4, and 7, encodes isoform c.
    Source sequence(s)
    AC004920, AC005153, AC080092
    Consensus CDS
    CCDS87503.1
    Conserved Domains (4) summary
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:108199
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  7. NM_001371008.1NP_001357937.1  growth factor receptor-bound protein 10 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 3, 4, and 6, encodes isoform c.
    Source sequence(s)
    AC004920, AC005153, AC080092
    Related
    ENSP00000495341.2, ENST00000645075.2
    Conserved Domains (4) summary
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:108199
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  8. NM_001371009.1NP_001357938.1  growth factor receptor-bound protein 10 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) encodes the longest isoform (f).
    Source sequence(s)
    AC004920, AC005153, AC080092
    Conserved Domains (4) summary
    cd10415
    Location:536643
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:335457
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:215306
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:475516
    BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    50590068..50793453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012043.1XP_016867532.1  growth factor receptor-bound protein 10 isoform X6

  2. XM_017012042.2XP_016867531.1  growth factor receptor-bound protein 10 isoform X6

  3. XM_017012061.2XP_016867550.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  4. XM_017012059.2XP_016867548.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  5. XM_024446729.1XP_024302497.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  6. XM_017012034.1XP_016867523.1  growth factor receptor-bound protein 10 isoform X5

  7. XM_024446726.1XP_024302494.1  growth factor receptor-bound protein 10 isoform X3

    Conserved Domains (4) summary
    cd01787
    Location:250331
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:570677
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:369491
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:509550
    BPS; BPS (Between PH and SH2)
  8. XM_024446730.1XP_024302498.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  9. XM_017012030.2XP_016867519.1  growth factor receptor-bound protein 10 isoform X2

  10. XM_017012031.2XP_016867520.1  growth factor receptor-bound protein 10 isoform X4

  11. XM_017012029.2XP_016867518.1  growth factor receptor-bound protein 10 isoform X1

  12. XM_017012033.1XP_016867522.1  growth factor receptor-bound protein 10 isoform X5

  13. XM_017012040.2XP_016867529.1  growth factor receptor-bound protein 10 isoform X6

  14. XM_017012038.2XP_016867527.1  growth factor receptor-bound protein 10 isoform X6

  15. XM_017012037.2XP_016867526.1  growth factor receptor-bound protein 10 isoform X6

  16. XM_017012036.2XP_016867525.1  growth factor receptor-bound protein 10 isoform X6

  17. XM_017012060.2XP_016867549.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  18. XM_017012055.2XP_016867544.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  19. XM_017012054.2XP_016867543.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  20. XM_017012050.2XP_016867539.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  21. XM_017012053.2XP_016867542.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  22. XM_017012049.2XP_016867538.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  23. XM_017012048.2XP_016867537.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  24. XM_017012047.2XP_016867536.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  25. XM_024446728.1XP_024302496.1  growth factor receptor-bound protein 10 isoform X9

    Conserved Domains (4) summary
    cd01787
    Location:160242
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:481588
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:280402
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:420461
    BPS; BPS (Between PH and SH2)
  26. XM_017012046.2XP_016867535.1  growth factor receptor-bound protein 10 isoform X8

    UniProtKB/Swiss-Prot
    Q13322
    Conserved Domains (4) summary
    cd01787
    Location:166248
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:487594
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:286408
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:426467
    BPS; BPS (Between PH and SH2)
  27. XM_017012032.1XP_016867521.1  growth factor receptor-bound protein 10 isoform X5

  28. XM_017012064.2XP_016867553.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Conserved Domains (4) summary
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:108199
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  29. XM_017012063.2XP_016867552.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Conserved Domains (4) summary
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:108199
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  30. XM_017012068.2XP_016867557.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Conserved Domains (4) summary
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:108199
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  31. XM_017012065.2XP_016867554.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Conserved Domains (4) summary
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:108199
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  32. XM_017012056.2XP_016867545.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  33. XM_011515316.1XP_011513618.1  growth factor receptor-bound protein 10 isoform X7

    See identical proteins and their annotated locations for XP_011513618.1

    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000385366.1, ENST00000406641.5
    Conserved Domains (4) summary
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:108199
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  34. XM_017012067.1XP_016867556.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000496245.1, ENST00000643299.1
    Conserved Domains (4) summary
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:108199
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  35. XM_017012039.1XP_016867528.1  growth factor receptor-bound protein 10 isoform X6

  36. XM_017012058.1XP_016867547.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  37. XM_017012062.2XP_016867551.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  38. XM_017012045.1XP_016867534.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000385189.1, ENST00000402578.5
    Conserved Domains (4) summary
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:108199
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  39. XM_011515323.3XP_011513625.1  growth factor receptor-bound protein 10 isoform X11

    Conserved Domains (5) summary
    cd01787
    Location:106187
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:426533
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:225347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:230338
    PH; PH domain
    pfam08947
    Location:365406
    BPS; BPS (Between PH and SH2)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005311.4: Suppressed sequence

    Description
    NM_005311.4: This RefSeq was removed because currently there is insufficient support for the transcript.
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