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GRB10 growth factor receptor bound protein 10 [ Homo sapiens (human) ]

Gene ID: 2887, updated on 7-Dec-2018

Summary

Official Symbol
GRB10provided by HGNC
Official Full Name
growth factor receptor bound protein 10provided by HGNC
Primary source
HGNC:HGNC:4564
See related
Ensembl:ENSG00000106070 MIM:601523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSS; IRBP; MEG1; GRB-IR; Grb-10
Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in thyroid (RPKM 6.6), kidney (RPKM 5.7) and 25 other tissues See more
Orthologs

Genomic context

See GRB10 in Genome Data Viewer
Location:
7p12.1
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (50590063..50793462, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (50657760..50861159, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs2059 Neighboring gene dopa decarboxylase Neighboring gene DDC antisense RNA 1 Neighboring gene ribosomal protein L39 pseudogene 23 Neighboring gene cordon-bleu WH2 repeat protein Neighboring gene ribosomal protein L7 like 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-03-23)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-03-23)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
A genetic locus in 7p12.2 associated with treatment resistant schizophrenia.
NHGRI GWA Catalog
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
NHGRI GWA Catalog
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
NHGRI GWA Catalog
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
NHGRI GWA Catalog

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • IGF1 pathway, organism-specific biosystem (from Pathway Interaction Database)
    IGF1 pathway, organism-specific biosystem
    IGF1 pathway
  • IRS activation, organism-specific biosystem (from REACTOME)
    IRS activation, organism-specific biosystemIRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned unde...
  • Insulin Pathway, organism-specific biosystem (from Pathway Interaction Database)
    Insulin Pathway, organism-specific biosystem
    Insulin Pathway
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
    Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
  • Kit receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Kit receptor signaling pathway, organism-specific biosystemKit is a cytokine receptor that belongs to the type III receptor tyrosine kinase family. It is structurally similar to platelet-derived growth factor recpetors (PDGFRs), colony stimulating factor-1 r...
  • PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    PDGFR-beta signaling pathway, organism-specific biosystem
    PDGFR-beta signaling pathway
  • PI3K-AKT-mTOR signaling pathway and therapeutic opportunities, organism-specific biosystem (from WikiPathways)
    PI3K-AKT-mTOR signaling pathway and therapeutic opportunities, organism-specific biosystemThis pathway is based on figure 1 from Merritt et al. (See Bibliography). The PI3K-AKT-mTOR signaling pathway has been shown to have a significant correlation with the development of castration-resis...
  • RET signaling, organism-specific biosystem (from REACTOME)
    RET signaling, organism-specific biosystemThe RET proto-oncogene encodes a receptor tyrosine kinase expressed primarily in urogenital precursor cells, spermatogonocytes, dopaminergic neurons, motor neurons and neural crest progenitors and de...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signal attenuation, organism-specific biosystem (from REACTOME)
    Signal attenuation, organism-specific biosystemNow with the complete receptor-ligand dissociation and subsequent degradation of insulin in the endosomal lumen, the endosomally associated protein tyrosine phosphatases (PTPs) complete the receptor ...
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
    Signaling events mediated by Stem cell factor receptor (c-Kit)
  • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
    Signaling events mediated by VEGFR1 and VEGFR2
  • Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem
    Signaling events regulated by Ret tyrosine kinase
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0207

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3/SH2 adaptor activity IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon guidance TAS
Traceable Author Statement
more info
 
insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
growth factor receptor-bound protein 10
Names
GRB10 adapter protein
GRB10 adaptor protein
insulin receptor-binding protein Grb-IR
maternally expressed gene 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012305.1 RefSeqGene

    Range
    5001..208400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001549.2NP_001001549.1  growth factor receptor-bound protein 10 isoform b

    See identical proteins and their annotated locations for NP_001001549.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as hGrb10alpha, lacks an in-frame segment in the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AC080092, AI360831, CX757289, U34355
    Consensus CDS
    CCDS47586.1
    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000349818.5, ENST00000357271.9
    Conserved Domains (4) summary
    cd01787
    Location:166248
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:441548
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:283362
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:380421
    BPS; BPS (Between PH and SH2)
  2. NM_001001550.2NP_001001550.1  growth factor receptor-bound protein 10 isoform c

    See identical proteins and their annotated locations for NP_001001550.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as hGrb10beta, differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a. Isoform c is encoded by transcript variants 3 and 4.
    Source sequence(s)
    AC080092, AI360831, CX757289, U66065, U69276
    Consensus CDS
    CCDS43583.1
    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000381790.2, ENST00000398810.6
    Conserved Domains (5) summary
    cd01787
    Location:108190
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:233341
    PH; PH domain
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  3. NM_001001555.2NP_001001555.1  growth factor receptor-bound protein 10 isoform c

    See identical proteins and their annotated locations for NP_001001555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a. Isoform c is encoded by transcript variants 3 and 4.
    Source sequence(s)
    AC005153, AC080092, AI360831, BC024285, BU598359, CX757289
    Consensus CDS
    CCDS43583.1
    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000338543.3, ENST00000335866.7
    Conserved Domains (5) summary
    cd01787
    Location:108190
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:233341
    PH; PH domain
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  4. NM_001350814.2NP_001337743.1  growth factor receptor-bound protein 10 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC004920, AC005153, AC080092
    Consensus CDS
    CCDS43582.1
    Related
    ENSP00000385770.1, ENST00000401949.5
    Conserved Domains (4) summary
    cd01787
    Location:166248
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:487594
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:286408
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:426467
    BPS; BPS (Between PH and SH2)
  5. NM_001350815.1NP_001337744.1  growth factor receptor-bound protein 10 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (d).
    Source sequence(s)
    AC004920, AC005153, AC080092, D86962
    Consensus CDS
    CCDS87504.1
    Related
    ENSP00000493728.1, ENST00000644879.1
    Conserved Domains (4) summary
    cd01787
    Location:204286
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:525632
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:324446
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:464505
    BPS; BPS (Between PH and SH2)
  6. NM_001350816.1NP_001337745.1  growth factor receptor-bound protein 10 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes isoform e.
    Source sequence(s)
    AC005153, AC080092, D86962
    Consensus CDS
    CCDS87503.1
    Related
    ENSP00000495341.1, ENST00000645075.1
    Conserved Domains (4) summary
    cd01787
    Location:160242
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:481588
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:280402
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:420461
    BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    50590063..50793462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012043.1XP_016867532.1  growth factor receptor-bound protein 10 isoform X6

  2. XM_017012042.2XP_016867531.1  growth factor receptor-bound protein 10 isoform X6

  3. XM_017012061.2XP_016867550.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  4. XM_017012059.2XP_016867548.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  5. XM_024446729.1XP_024302497.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  6. XM_017012034.1XP_016867523.1  growth factor receptor-bound protein 10 isoform X5

  7. XM_024446726.1XP_024302494.1  growth factor receptor-bound protein 10 isoform X3

    Conserved Domains (4) summary
    cd01787
    Location:250331
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:570677
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:369491
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:509550
    BPS; BPS (Between PH and SH2)
  8. XM_024446730.1XP_024302498.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  9. XM_017012030.2XP_016867519.1  growth factor receptor-bound protein 10 isoform X2

  10. XM_017012031.2XP_016867520.1  growth factor receptor-bound protein 10 isoform X4

  11. XM_017012029.2XP_016867518.1  growth factor receptor-bound protein 10 isoform X1

  12. XM_017012033.1XP_016867522.1  growth factor receptor-bound protein 10 isoform X5

  13. XM_017012040.2XP_016867529.1  growth factor receptor-bound protein 10 isoform X6

  14. XM_017012038.2XP_016867527.1  growth factor receptor-bound protein 10 isoform X6

  15. XM_017012037.2XP_016867526.1  growth factor receptor-bound protein 10 isoform X6

  16. XM_017012036.2XP_016867525.1  growth factor receptor-bound protein 10 isoform X6

  17. XM_017012060.2XP_016867549.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  18. XM_017012055.2XP_016867544.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  19. XM_017012054.2XP_016867543.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  20. XM_017012050.2XP_016867539.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  21. XM_017012053.2XP_016867542.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  22. XM_017012049.2XP_016867538.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  23. XM_017012048.2XP_016867537.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  24. XM_017012047.2XP_016867536.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  25. XM_024446728.1XP_024302496.1  growth factor receptor-bound protein 10 isoform X9

    Conserved Domains (4) summary
    cd01787
    Location:160242
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:481588
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:280402
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:420461
    BPS; BPS (Between PH and SH2)
  26. XM_017012046.2XP_016867535.1  growth factor receptor-bound protein 10 isoform X8

    UniProtKB/Swiss-Prot
    Q13322
    Conserved Domains (4) summary
    cd01787
    Location:166248
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:487594
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:286408
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:426467
    BPS; BPS (Between PH and SH2)
  27. XM_017012032.1XP_016867521.1  growth factor receptor-bound protein 10 isoform X5

  28. XM_017012064.2XP_016867553.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Conserved Domains (5) summary
    cd01787
    Location:108190
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:233341
    PH; PH domain
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  29. XM_017012063.2XP_016867552.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Conserved Domains (5) summary
    cd01787
    Location:108190
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:233341
    PH; PH domain
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  30. XM_017012068.2XP_016867557.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Conserved Domains (5) summary
    cd01787
    Location:108190
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:233341
    PH; PH domain
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  31. XM_017012065.2XP_016867554.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Conserved Domains (5) summary
    cd01787
    Location:108190
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:233341
    PH; PH domain
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  32. XM_017012056.2XP_016867545.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  33. XM_011515316.1XP_011513618.1  growth factor receptor-bound protein 10 isoform X7

    See identical proteins and their annotated locations for XP_011513618.1

    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000385366.1, ENST00000406641.5
    Conserved Domains (5) summary
    cd01787
    Location:108190
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:233341
    PH; PH domain
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  34. XM_017012067.1XP_016867556.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000496245.1, ENST00000643299.1
    Conserved Domains (5) summary
    cd01787
    Location:108190
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:233341
    PH; PH domain
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  35. XM_017012039.1XP_016867528.1  growth factor receptor-bound protein 10 isoform X6

  36. XM_017012058.1XP_016867547.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  37. XM_017012062.2XP_016867551.1  growth factor receptor-bound protein 10 isoform X10

    Conserved Domains (4) summary
    cd01787
    Location:154235
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:474581
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:273395
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:413454
    BPS; BPS (Between PH and SH2)
  38. XM_017012045.1XP_016867534.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/Swiss-Prot
    Q13322
    Related
    ENSP00000385189.1, ENST00000402578.5
    Conserved Domains (5) summary
    cd01787
    Location:108190
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:429536
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:228350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:233341
    PH; PH domain
    pfam08947
    Location:368409
    BPS; BPS (Between PH and SH2)
  39. XM_011515323.3XP_011513625.1  growth factor receptor-bound protein 10 isoform X11

    Conserved Domains (5) summary
    cd01787
    Location:106187
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:426533
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:225347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:230338
    PH; PH domain
    pfam08947
    Location:365406
    BPS; BPS (Between PH and SH2)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005311.4: Suppressed sequence

    Description
    NM_005311.4: This RefSeq was removed because currently there is insufficient support for the transcript.
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