GRB10 growth factor receptor bound protein 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GRB10provided by HGNC
Official Full Name: growth factor receptor bound protein 10provided by HGNC
Primary source: HGNC:HGNC:4564
See related: Ensembl:ENSG00000106070 MIM:601523; AllianceGenome:HGNC:4564
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RSS; IRBP; MEG1; GRB-IR; Grb-10
Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Expression: Ubiquitous expression in thyroid (RPKM 6.6), kidney (RPKM 5.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p12.1

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (50590068..50793453, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (50751214..50954643, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (50657765..50861150, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRB10 is a novel factor associated with gastric cancer proliferation and prognosis.
Title: GRB10 is a novel factor associated with gastric cancer proliferation and prognosis.
Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p/GRB10 axis.
Title: Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p/GRB10 axis.
GRB10 sustains AR activity by interacting with PP2A in prostate cancer cells.
Title: GRB10 sustains AR activity by interacting with PP2A in prostate cancer cells.
inhibition of mTORC1 with rapamycin blocked Grb10 Ser476 phosphorylation and repressed a negative-feedback loop on PI3K/Akt signaling that increased myotube responsiveness to insulin
Title: Role of Grb10 in mTORC1-dependent regulation of insulin signaling and action in human skeletal muscle cells.
results suggest that GRB10 acts as a major downstream effector of PI3K and has tumor-promoting effects in prostate cancer
Title: Proproliferative function of adaptor protein GRB10 in prostate carcinoma.
Using state-of-the-art patient-derived hormone-naive prostate cancer xenograft models,we found and validated the growth factor receptor bound protein 10 gene as a driver of CRPC.
Title: Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer.
Through syngeneic comparison, our study identifies for the first time that Grb10 is associated with the pluripotency state in nuclear transfer embryonic stem cells.
Title: High throughput sequencing identifies an imprinted gene, Grb10, associated with the pluripotency state in nuclear transfer embryonic stem cells.
Study found FGFR3 gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset
Title: FGFR3 gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset.
Data suggest that GRB10 and GRB14 are both Ca2+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 and GRB14, as compared to a single one present in GRB7. (GRB10 = growth factor receptor-bound protein 10; GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 = growth factor receptor-bound protein 7)
Title: The adaptors Grb10 and Grb14 are calmodulin-binding proteins.
GRB10 may regulate degradation of the IL-4 receptor-signaling complex through interactions with NEDD4.2.
Title: The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2012-03-23) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2012-03-23) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genetic locus in 7p12.2 associated with treatment resistant schizophrenia. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. EBI GWAS Catalog EBI GWAS CatalogPubMed
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-52576 (e-PCR)
- UniSTS:90652

RH11858 (e-PCR)
- UniSTS:76596

GDB:4585083 (e-PCR)
- UniSTS:60981

GDB:6028674 (e-PCR)
- UniSTS:44100

D7S3125 (e-PCR)
- UniSTS:186692

WI-18551 (e-PCR)
- UniSTS:42058

GDB:1317480 (e-PCR)
- UniSTS:39756

D7S2137E (e-PCR)
- UniSTS:151135

SHGC-23058 (e-PCR)
- UniSTS:41826

RH25419 (e-PCR)
- UniSTS:71811

RH65056 (e-PCR)
- UniSTS:75405

GDB:4585598 (e-PCR)
- UniSTS:53430

MARC_51491-51492:1152645911:1 (e-PCR)
- UniSTS:508091

WI-14569 (e-PCR)
- UniSTS:81096

SHGC-79976 (e-PCR)
- UniSTS:101609

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor complex adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of D-glucose import	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glycogen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in response to insulin	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular associated smooth muscle cell migration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: growth factor receptor-bound protein 10

Names: GRB10 adapter protein; GRB10 adaptor protein; insulin receptor-binding protein Grb-IR; maternally expressed gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012305.2 RefSeqGene

Range

5010..208395

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1032

mRNA and Protein(s)

NM_001001549.3 → NP_001001549.1 growth factor receptor-bound protein 10 isoform b

See identical proteins and their annotated locations for NP_001001549.1

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as hGrb10alpha, lacks an in-frame segment in the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.

Source sequence(s)

AC005153, AC080092

Consensus CDS

CCDS47586.1

UniProtKB/Swiss-Prot

Q13322

Related

ENSP00000349818.5, ENST00000357271.9

Conserved Domains (4) summary

cd01787
Location:166 → 248

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10415
Location:441 → 548

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:283 → 362

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:380 → 421

BPS; BPS (Between PH and SH2)
NM_001001550.3 → NP_001001550.1 growth factor receptor-bound protein 10 isoform c

See identical proteins and their annotated locations for NP_001001550.1

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as hGrb10beta, differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a. Isoform c is encoded by transcript variants 4, 6, and 7.

Source sequence(s)

AC005153, AC080092

Consensus CDS

CCDS43583.1

UniProtKB/Swiss-Prot

Q13322

Related

ENSP00000381790.2, ENST00000398810.6

Conserved Domains (4) summary

cd10415
Location:429 → 536

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:228 → 350

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:108 → 199

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:368 → 409

BPS; BPS (Between PH and SH2)
NM_001001555.3 → NP_001001555.1 growth factor receptor-bound protein 10 isoform c

See identical proteins and their annotated locations for NP_001001555.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a. Isoform c is encoded by transcript variants 3, 4, 6, and 7.

Source sequence(s)

AC004920, AC005153, AC080092

Consensus CDS

CCDS43583.1

UniProtKB/Swiss-Prot

Q13322

Related

ENSP00000338543.3, ENST00000335866.7

Conserved Domains (4) summary

cd10415
Location:429 → 536

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:228 → 350

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:108 → 199

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:368 → 409

BPS; BPS (Between PH and SH2)
NM_001350814.2 → NP_001337743.1 growth factor receptor-bound protein 10 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AC004920, AC005153, AC080092

Consensus CDS

CCDS43582.1

UniProtKB/Swiss-Prot

A4D258, A7VJ95, A8K0E6, D3DVM9, O00427, O00701, O75222, Q13322, Q92606, Q92907, Q92948

Related

ENSP00000385770.1, ENST00000401949.6

Conserved Domains (4) summary

cd01787
Location:166 → 248

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10415
Location:487 → 594

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:286 → 408

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:426 → 467

BPS; BPS (Between PH and SH2)
NM_001350815.2 → NP_001337744.1 growth factor receptor-bound protein 10 isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (5) encodes isoform d.

Source sequence(s)

AC004920, AC005153, AC080092

Consensus CDS

CCDS87504.1

UniProtKB/TrEMBL

A0A2R8YCL1

Related

ENSP00000493728.1, ENST00000644879.1

Conserved Domains (4) summary

cd01787
Location:204 → 286

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10415
Location:525 → 632

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:324 → 446

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:464 → 505

BPS; BPS (Between PH and SH2)
NM_001350816.3 → NP_001337745.2 growth factor receptor-bound protein 10 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 3, 4, and 7, encodes isoform c.

Source sequence(s)

AC004920, AC005153, AC080092

Consensus CDS

CCDS43583.1

Conserved Domains (4) summary

cd10415
Location:429 → 536

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:228 → 350

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:108 → 199

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:368 → 409

BPS; BPS (Between PH and SH2)
NM_001371008.1 → NP_001357937.1 growth factor receptor-bound protein 10 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (7), as well as variants 3, 4, and 6, encodes isoform c.

Source sequence(s)

AC004920, AC005153, AC080092

Consensus CDS

CCDS43583.1

Related

ENSP00000495341.2, ENST00000645075.2

Conserved Domains (4) summary

cd10415
Location:429 → 536

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:228 → 350

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:108 → 199

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:368 → 409

BPS; BPS (Between PH and SH2)
NM_001371009.1 → NP_001357938.1 growth factor receptor-bound protein 10 isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (8) encodes the longest isoform (f).

Source sequence(s)

AC004920, AC005153, AC080092

Conserved Domains (3) summary

cd10415
Location:536 → 643

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:335 → 457

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:215 → 306

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

50590068..50793453 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017012061.3 → XP_016867550.1 growth factor receptor-bound protein 10 isoform X11

Conserved Domains (4) summary

cd01787
Location:154 → 235

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10415
Location:474 → 581

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:273 → 395

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:413 → 454

BPS; BPS (Between PH and SH2)
XM_047420243.1 → XP_047276199.1 growth factor receptor-bound protein 10 isoform X10
XM_047420233.1 → XP_047276189.1 growth factor receptor-bound protein 10 isoform X6
XM_047420241.1 → XP_047276197.1 growth factor receptor-bound protein 10 isoform X8

UniProtKB/Swiss-Prot

A4D258, A7VJ95, A8K0E6, D3DVM9, O00427, O00701, O75222, Q13322, Q92606, Q92907, Q92948

Related

ENSP00000381793.2, ENST00000398812.6
XM_017012034.2 → XP_016867523.1 growth factor receptor-bound protein 10 isoform X5
XM_047420252.1 → XP_047276208.1 growth factor receptor-bound protein 10 isoform X7
XM_047420244.1 → XP_047276200.1 growth factor receptor-bound protein 10 isoform X10
XM_047420240.1 → XP_047276196.1 growth factor receptor-bound protein 10 isoform X6
XM_024446726.2 → XP_024302494.1 growth factor receptor-bound protein 10 isoform X3

Conserved Domains (4) summary

cd01787
Location:250 → 331

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10415
Location:570 → 677

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:369 → 491

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:509 → 550

BPS; BPS (Between PH and SH2)
XM_017012030.3 → XP_016867519.1 growth factor receptor-bound protein 10 isoform X2
XM_017012031.3 → XP_016867520.1 growth factor receptor-bound protein 10 isoform X4
XM_017012029.3 → XP_016867518.1 growth factor receptor-bound protein 10 isoform X1
XM_047420253.1 → XP_047276209.1 growth factor receptor-bound protein 10 isoform X7
XM_047420254.1 → XP_047276210.1 growth factor receptor-bound protein 10 isoform X7
XM_047420255.1 → XP_047276211.1 growth factor receptor-bound protein 10 isoform X7
XM_047420238.1 → XP_047276194.1 growth factor receptor-bound protein 10 isoform X6
XM_047420232.1 → XP_047276188.1 growth factor receptor-bound protein 10 isoform X5
XM_047420250.1 → XP_047276206.1 growth factor receptor-bound protein 10 isoform X11
XM_024446729.2 → XP_024302497.1 growth factor receptor-bound protein 10 isoform X11

Conserved Domains (4) summary

cd01787
Location:154 → 235

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10415
Location:474 → 581

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:273 → 395

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:413 → 454

BPS; BPS (Between PH and SH2)
XM_047420249.1 → XP_047276205.1 growth factor receptor-bound protein 10 isoform X11
XM_047420247.1 → XP_047276203.1 growth factor receptor-bound protein 10 isoform X11
XM_047420236.1 → XP_047276192.1 growth factor receptor-bound protein 10 isoform X6
XM_047420248.1 → XP_047276204.1 growth factor receptor-bound protein 10 isoform X11
XM_047420246.1 → XP_047276202.1 growth factor receptor-bound protein 10 isoform X11
XM_047420235.1 → XP_047276191.1 growth factor receptor-bound protein 10 isoform X6
XM_047420234.1 → XP_047276190.1 growth factor receptor-bound protein 10 isoform X6
XM_047420245.1 → XP_047276201.1 growth factor receptor-bound protein 10 isoform X11
XM_047420251.1 → XP_047276207.1 growth factor receptor-bound protein 10 isoform X11
XM_047420237.1 → XP_047276193.1 growth factor receptor-bound protein 10 isoform X6
XM_017012058.1 → XP_016867547.1 growth factor receptor-bound protein 10 isoform X11

Conserved Domains (4) summary

cd01787
Location:154 → 235

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10415
Location:474 → 581

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:273 → 395

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:413 → 454

BPS; BPS (Between PH and SH2)
XM_017012062.3 → XP_016867551.1 growth factor receptor-bound protein 10 isoform X11

Conserved Domains (4) summary

cd01787
Location:154 → 235

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10415
Location:474 → 581

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:273 → 395

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:413 → 454

BPS; BPS (Between PH and SH2)
XM_017012045.1 → XP_016867534.1 growth factor receptor-bound protein 10 isoform X7

UniProtKB/Swiss-Prot

Q13322

Related

ENSP00000385189.1, ENST00000402578.5

Conserved Domains (4) summary

cd10415
Location:429 → 536

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:228 → 350

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:108 → 199

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:368 → 409

BPS; BPS (Between PH and SH2)
XM_047420242.1 → XP_047276198.1 growth factor receptor-bound protein 10 isoform X9
XM_047420256.1 → XP_047276212.1 growth factor receptor-bound protein 10 isoform X12

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

50751214..50954643 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054357968.1 → XP_054213943.1 growth factor receptor-bound protein 10 isoform X11
XM_054357966.1 → XP_054213941.1 growth factor receptor-bound protein 10 isoform X10
XM_054357957.1 → XP_054213932.1 growth factor receptor-bound protein 10 isoform X6
XM_054357964.1 → XP_054213939.1 growth factor receptor-bound protein 10 isoform X8

UniProtKB/Swiss-Prot

A4D258, A7VJ95, A8K0E6, D3DVM9, O00427, O00701, O75222, Q13322, Q92606, Q92907, Q92948
XM_054357956.1 → XP_054213931.1 growth factor receptor-bound protein 10 isoform X5
XM_054357979.1 → XP_054213954.1 growth factor receptor-bound protein 10 isoform X7
XM_054357953.1 → XP_054213928.1 growth factor receptor-bound protein 10 isoform X3
XM_054357967.1 → XP_054213942.1 growth factor receptor-bound protein 10 isoform X10
XM_054357952.1 → XP_054213927.1 growth factor receptor-bound protein 10 isoform X2
XM_054357954.1 → XP_054213929.1 growth factor receptor-bound protein 10 isoform X4
XM_054357951.1 → XP_054213926.1 growth factor receptor-bound protein 10 isoform X1
XM_054357980.1 → XP_054213955.1 growth factor receptor-bound protein 10 isoform X7
XM_054357981.1 → XP_054213956.1 growth factor receptor-bound protein 10 isoform X7
XM_054357962.1 → XP_054213937.1 growth factor receptor-bound protein 10 isoform X6
XM_054357955.1 → XP_054213930.1 growth factor receptor-bound protein 10 isoform X5
XM_054357976.1 → XP_054213951.1 growth factor receptor-bound protein 10 isoform X11
XM_054357973.1 → XP_054213948.1 growth factor receptor-bound protein 10 isoform X11
XM_054357975.1 → XP_054213950.1 growth factor receptor-bound protein 10 isoform X11
XM_054357971.1 → XP_054213946.1 growth factor receptor-bound protein 10 isoform X11
XM_054357960.1 → XP_054213935.1 growth factor receptor-bound protein 10 isoform X6
XM_054357974.1 → XP_054213949.1 growth factor receptor-bound protein 10 isoform X11
XM_054357970.1 → XP_054213945.1 growth factor receptor-bound protein 10 isoform X11
XM_054357959.1 → XP_054213934.1 growth factor receptor-bound protein 10 isoform X6
XM_054357958.1 → XP_054213933.1 growth factor receptor-bound protein 10 isoform X6
XM_054357969.1 → XP_054213944.1 growth factor receptor-bound protein 10 isoform X11
XM_054357977.1 → XP_054213952.1 growth factor receptor-bound protein 10 isoform X11
XM_054357961.1 → XP_054213936.1 growth factor receptor-bound protein 10 isoform X6
XM_054357972.1 → XP_054213947.1 growth factor receptor-bound protein 10 isoform X11
XM_054357978.1 → XP_054213953.1 growth factor receptor-bound protein 10 isoform X11
XM_054357963.1 → XP_054213938.1 growth factor receptor-bound protein 10 isoform X7
XM_054357965.1 → XP_054213940.1 growth factor receptor-bound protein 10 isoform X9
XM_054357982.1 → XP_054213957.1 growth factor receptor-bound protein 10 isoform X12

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_005311.4: Suppressed sequence

Description

NM_005311.4: This RefSeq was removed because currently there is insufficient support for the transcript.