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P2RY8 P2Y receptor family member 8 [ Homo sapiens (human) ]

Gene ID: 286530, updated on 11-Jun-2021

Summary

Official Symbol
P2RY8provided by HGNC
Official Full Name
P2Y receptor family member 8provided by HGNC
Primary source
HGNC:HGNC:15524
See related
Ensembl:ENSG00000182162 MIM:300525
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2Y8
Summary
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 13.9), spleen (RPKM 8.9) and 14 other tissues See more
Orthologs
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Genomic context

See P2RY8 in Genome Data Viewer
Location:
X;Y
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (1462576..1537488, complement)
109.20210514 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (1462576..1537488, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1581474..1656078, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1531474..1606078, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene A-kinase anchoring protein 17A Neighboring gene acetylserotonin O-methyltransferase Neighboring gene uncharacterized LOC107985706

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene A-kinase anchoring protein 17A Neighboring gene acetylserotonin O-methyltransferase Neighboring gene uncharacterized LOC107985706

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC50878

General protein information

Preferred Names
P2Y purinoceptor 8
Names
G-protein coupled purinergic receptor P2Y8
purinergic receptor P2Y, G-protein coupled, 8
purinergic receptor P2Y8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013252.1 RefSeqGene

    Range
    4960..79564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178129.5NP_835230.1  P2Y purinoceptor 8

    See identical proteins and their annotated locations for NP_835230.1

    Status: REVIEWED

    Source sequence(s)
    AI476104, AK092956, AL683870, AL833184, BC043610, BE245848
    Consensus CDS
    CCDS14115.1
    UniProtKB/Swiss-Prot
    Q86VZ1
    Related
    ENSP00000370697.4, ENST00000381297.10
    Conserved Domains (1) summary
    cd15368
    Location:24304
    7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    1462576..1537488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724443.3XP_006724506.2  P2Y purinoceptor 8 isoform X1

    See identical proteins and their annotated locations for XP_006724506.2

    Conserved Domains (2) summary
    pfam00001
    Location:229482
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:222321
    7tm_4; Olfactory receptor
  2. XM_011546178.2XP_011544480.1  P2Y purinoceptor 8 isoform X2

    See identical proteins and their annotated locations for XP_011544480.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    cd15368
    Location:24304
    7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_011546179.2XP_011544481.1  P2Y purinoceptor 8 isoform X2

    See identical proteins and their annotated locations for XP_011544481.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    cd15368
    Location:24304
    7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_005274429.3XP_005274486.1  P2Y purinoceptor 8 isoform X2

    See identical proteins and their annotated locations for XP_005274486.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    cd15368
    Location:24304
    7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    1462576..1537488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724864.3XP_006724927.2  P2Y purinoceptor 8 isoform X1

    See identical proteins and their annotated locations for XP_006724927.2

    Conserved Domains (2) summary
    pfam00001
    Location:229482
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:222321
    7tm_4; Olfactory receptor
  2. XM_011545631.2XP_011543933.1  P2Y purinoceptor 8 isoform X2

    See identical proteins and their annotated locations for XP_011543933.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    cd15368
    Location:24304
    7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_011545632.2XP_011543934.1  P2Y purinoceptor 8 isoform X2

    See identical proteins and their annotated locations for XP_011543934.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    cd15368
    Location:24304
    7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_005274778.3XP_005274835.1  P2Y purinoceptor 8 isoform X2

    See identical proteins and their annotated locations for XP_005274835.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    cd15368
    Location:24304
    7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors
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