Format

Send to:

Choose Destination

TMSB15B thymosin beta 15B [ Homo sapiens (human) ]

Gene ID: 286527, updated on 1-Aug-2020

Summary

Official Symbol
TMSB15Bprovided by HGNC
Official Full Name
thymosin beta 15Bprovided by HGNC
Primary source
HGNC:HGNC:28612
See related
Ensembl:ENSG00000158427 MIM:301011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMSL8; TMSNB; TMSB15A; Tbeta15b
Expression
Ubiquitous expression in ovary (RPKM 5.0), endometrium (RPKM 4.8) and 22 other tissues See more
Orthologs

Genomic context

See TMSB15B in Genome Data Viewer
Location:
Xq22.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (103918896..103974426)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (103217200..103220563)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TMSB15B antisense RNA 1 Neighboring gene H2B histone pseudogene 9 Neighboring gene ELF2 pseudogene 1 Neighboring gene SLC25A53 pseudogene 1 Neighboring gene developmental pluripotency associated 3 pseudogene 1 Neighboring gene uncharacterized LOC107987334 Neighboring gene H2B.W histone 4, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Potential readthrough

Included gene: H2BW4P

Homology

Clone Names

  • MGC39900

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thymosin beta-15B
Names
NB thymosin beta
Thymosin beta-15A
Thymosin-like protein 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350211.1NP_001337140.1  thymosin beta-15B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and contains a longer 5' UTR compared to variant 1.
    Source sequence(s)
    AC234782, BC019900, BQ011701
    Consensus CDS
    CCDS59172.1
    Related
    ENSP00000456121.1, ENST00000419165.5
    Conserved Domains (1) summary
    pfam01290
    Location:339
    Thymosin; Thymosin beta-4 family
  2. NM_001350212.1NP_001337141.1  thymosin beta-15B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR compared to variant 1.
    Source sequence(s)
    AC234782, BQ011701, CN271772
    Consensus CDS
    CCDS59172.1
    Related
    ENSP00000457057.1, ENST00000569577.1
    Conserved Domains (1) summary
    pfam01290
    Location:339
    Thymosin; Thymosin beta-4 family
  3. NM_001350213.1NP_001337142.1  thymosin beta-15B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and differs in both the 5' and 3' exon structure compared to variant 1. The encoded isoform (2) has a longer, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC234782
    Conserved Domains (1) summary
    pfam01290
    Location:333
    Thymosin; Thymosin beta-4 family
  4. NM_194324.4NP_919305.2  thymosin beta-15B isoform 1

    See identical proteins and their annotated locations for NP_919305.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the canonical isoform (1).
    Source sequence(s)
    BC093093, BQ011701
    Consensus CDS
    CCDS59172.1
    UniProtKB/Swiss-Prot
    P0CG34, P0CG35
    Related
    ENSP00000455371.1, ENST00000540220.6
    Conserved Domains (1) summary
    pfam01290
    Location:339
    Thymosin; Thymosin beta-4 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    103918896..103974426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center