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NLRP2B NLR family pyrin domain containing 2B [ Homo sapiens (human) ]

Gene ID: 286430, updated on 22-May-2022

Summary

Official Symbol
NLRP2Bprovided by HGNC
Official Full Name
NLR family pyrin domain containing 2Bprovided by HGNC
Primary source
HGNC:HGNC:29887
See related
Ensembl:ENSG00000215174 AllianceGenome:HGNC:29887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POP4; NOD24; CLRX.1; NALP2P; NLRP2P
Summary
Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of peptidyl-serine phosphorylation; and negative regulation of signal transduction. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See NLRP2B in Genome Data Viewer
Location:
Xp11.21
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (57677067..57680260, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (56975852..56979045, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (57703500..57706693, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger X-linked duplicated B Neighboring gene uncharacterized LOC107985708 Neighboring gene MDH1 pseudogene 1 Neighboring gene uncharacterized LOC124905232 Neighboring gene Sharpr-MPRA regulatory region 7453

Genomic regions, transcripts, and products

General gene information

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NLR family pyrin domain-containing protein 2B
Names
NLR family and pyrin domain-containing 2 pseudogene
NLR family, pyrin domain containing 2 pseudogene
NOD24 pseudogene
Pyrin domain-containing protein 2-like protein POP4
Pyrin-only protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319967.1NP_001306896.1  NLR family pyrin domain-containing protein 2B

    Status: VALIDATED

    Source sequence(s)
    AL807813
    Consensus CDS
    CCDS83476.1
    UniProtKB/Swiss-Prot
    P0DMW2
    Related
    ENSP00000488995.1, ENST00000434992.1
    Conserved Domains (1) summary
    cl14633
    Location:1145
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    57677067..57680260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    56975852..56979045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_002752.4: Suppressed sequence

    Description
    NG_002752.4: This RefSeq was removed because it is now thought that this gene does encode a protein.