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FFAR1 free fatty acid receptor 1 [ Homo sapiens (human) ]

Gene ID: 2864, updated on 23-Nov-2021

Summary

Official Symbol
FFAR1provided by HGNC
Official Full Name
free fatty acid receptor 1provided by HGNC
Primary source
HGNC:HGNC:4498
See related
Ensembl:ENSG00000126266 MIM:603820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FFA1R; GPR40; GPCR40
Summary
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
Orthologs
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Genomic context

See FFAR1 in Genome Data Viewer
Location:
19q13.12
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35347902..35353864)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35842445..35843367)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene myelin associated glycoprotein Neighboring gene CD22 molecule Neighboring gene microRNA 5196 Neighboring gene free fatty acid receptor 3 Neighboring gene G protein-coupled receptor 42

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

General protein information

Preferred Names
free fatty acid receptor 1
Names
G-protein coupled receptor 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005303.3NP_005294.1  free fatty acid receptor 1

    See identical proteins and their annotated locations for NP_005294.1

    Status: REVIEWED

    Source sequence(s)
    KF511268, U62631
    Consensus CDS
    CCDS12458.1
    UniProtKB/Swiss-Prot
    O14842
    Related
    ENSP00000246553.2, ENST00000246553.3
    Conserved Domains (1) summary
    cd15169
    Location:6289
    7tmA_FFAR1; free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35347902..35353864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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