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FFAR1 free fatty acid receptor 1 [ Homo sapiens (human) ]

Gene ID: 2864, updated on 22-Sep-2022

Summary

Official Symbol
FFAR1provided by HGNC
Official Full Name
free fatty acid receptor 1provided by HGNC
Primary source
HGNC:HGNC:4498
See related
Ensembl:ENSG00000126266 MIM:603820; AllianceGenome:HGNC:4498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FFA1R; GPR40; GPCR40
Summary
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
Orthologs
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Genomic context

See FFAR1 in Genome Data Viewer
Location:
19q13.12
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35347902..35353864)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37892634..37898598)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35838805..35844766)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene myelin associated glycoprotein Neighboring gene CD22 molecule Neighboring gene microRNA 5196 Neighboring gene free fatty acid receptor 3 Neighboring gene G protein-coupled receptor 42

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bioactive lipid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bioactive lipid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
free fatty acid receptor 1
Names
G-protein coupled receptor 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005303.3NP_005294.1  free fatty acid receptor 1

    See identical proteins and their annotated locations for NP_005294.1

    Status: REVIEWED

    Source sequence(s)
    KF511268, U62631
    Consensus CDS
    CCDS12458.1
    UniProtKB/Swiss-Prot
    O14842, Q4VBL4
    Related
    ENSP00000246553.2, ENST00000246553.4
    Conserved Domains (1) summary
    cd15169
    Location:6289
    7tmA_FFAR1; free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35347902..35353864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438698.1XP_047294654.1  free fatty acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q4VBL4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    37892634..37898598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)