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GPR39 G protein-coupled receptor 39 [ Homo sapiens (human) ]

Gene ID: 2863, updated on 26-Sep-2021

Summary

Official Symbol
GPR39provided by HGNC
Official Full Name
G protein-coupled receptor 39provided by HGNC
Primary source
HGNC:HGNC:4496
See related
Ensembl:ENSG00000183840 MIM:602886
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]
Expression
Broad expression in brain (RPKM 4.2), colon (RPKM 3.1) and 19 other tissues See more
Orthologs
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Genomic context

See GPR39 in Genome Data Viewer
Location:
2q21.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (132416805..132646582)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (133174378..133404155)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6129 Neighboring gene Sharpr-MPRA regulatory region 6766 Neighboring gene RNA, U6 small nuclear 175, pseudogene Neighboring gene microRNA 9986 Neighboring gene RN7SK pseudogene 103 Neighboring gene Y-box binding protein 1 pseudogene 7 Neighboring gene uncharacterized LOC105373623 Neighboring gene LY6/PLAUR domain containing 1 Neighboring gene NCK associated protein 5 Neighboring gene Sharpr-MPRA regulatory region 3189

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Two-marker association tests yield new disease associations for coronary artery disease and hypertension.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149541

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G-protein coupled receptor 39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050928.1 RefSeqGene

    Range
    5645..235422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001508.3NP_001499.1  G-protein coupled receptor 39

    See identical proteins and their annotated locations for NP_001499.1

    Status: REVIEWED

    Source sequence(s)
    AI459805, BC125046, BM981455, DA636860, DA653793
    Consensus CDS
    CCDS2170.1
    UniProtKB/Swiss-Prot
    O43194
    Related
    ENSP00000327417.3, ENST00000329321.4
    Conserved Domains (1) summary
    cd15135
    Location:31355
    7tmA_GPR39; G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    132416805..132646582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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