Format

Send to:

Choose Destination

GPR37 G protein-coupled receptor 37 [ Homo sapiens (human) ]

Gene ID: 2861, updated on 24-Nov-2020

Summary

Official Symbol
GPR37provided by HGNC
Official Full Name
G protein-coupled receptor 37provided by HGNC
Primary source
HGNC:HGNC:4494
See related
Ensembl:ENSG00000170775 MIM:602583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAELR; EDNRBL; hET(B)R-LP
Summary
This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
Expression
Biased expression in brain (RPKM 26.2), testis (RPKM 10.2) and 4 other tissues See more
Orthologs

Genomic context

See GPR37 in Genome Data Viewer
Location:
7q31.33
Exon count:
2
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (124743885..124765792, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (124385655..124406079, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986842 Neighboring gene ribosomal protein S2 pseudogene 31 Neighboring gene RNA, U6 small nuclear 102, pseudogene Neighboring gene chromosome 7 open reading frame 77 Neighboring gene protection of telomeres 1 Neighboring gene Sharpr-MPRA regulatory region 5954

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study for reading and language abilities in two population cohorts.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled peptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
neuropeptide binding IPI
Inferred from Physical Interaction
more info
PubMed 
neuropeptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide binding IPI
Inferred from Physical Interaction
more info
PubMed 
prosaposin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prosaposin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prosaposin receptor GPR37
Names
ETBR-LP-1
G protein-coupled receptor 37 (endothelin receptor type B-like)
Parkin-associated endothelin receptor-like receptor
endothelin B receptor-like protein 1
probable G-protein coupled receptor 37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005302.5NP_005293.1  prosaposin receptor GPR37 precursor

    See identical proteins and their annotated locations for NP_005293.1

    Status: REVIEWED

    Source sequence(s)
    AC004925, AF017262
    Consensus CDS
    CCDS5792.1
    UniProtKB/Swiss-Prot
    O15354
    Related
    ENSP00000306449.2, ENST00000303921.3
    Conserved Domains (1) summary
    cd15127
    Location:262560
    7tmA_GPR37; G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    124743885..124765792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center