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GPR37 G protein-coupled receptor 37 [ Homo sapiens (human) ]

Gene ID: 2861, updated on 2-Nov-2024

Summary

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Official Symbol
GPR37provided by HGNC
Official Full Name
G protein-coupled receptor 37provided by HGNC
Primary source
HGNC:HGNC:4494
See related
Ensembl:ENSG00000170775 MIM:602583; AllianceGenome:HGNC:4494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAELR; EDNRBL; hET(B)R-LP
Summary
This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
Expression
Biased expression in brain (RPKM 26.2), testis (RPKM 10.2) and 4 other tissues See more
Orthologs
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Genomic context

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See GPR37 in Genome Data Viewer
Location:
7q31.33
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (124743885..124765792, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (126061240..126083145, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (124383939..124405846, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 31 Neighboring gene RNA, U6 small nuclear 102, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:124371425-124371925 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:124372079-124372580 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:124374223-124374759 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:124397814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18589 Neighboring gene Sharpr-MPRA regulatory region 5263 Neighboring gene long intergenic non-protein coding RNA 3043 Neighboring gene Sharpr-MPRA regulatory region 10744 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:124449868 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:124472442-124472991 Neighboring gene protection of telomeres 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:124533191-124533332 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:124542275 Neighboring gene Sharpr-MPRA regulatory region 5954

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer. Liu H, et al. Cancer Med, 2023 Oct. PMID 37732632, Free PMC Article
  2. A novel endothelin receptor type-B-like gene enriched in the brain. Zeng Z, et al. Biochem Biophys Res Commun, 1997 Apr 17. PMID 9144577
  3. Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library. Marazziti D, et al. Genomics, 1997 Oct 1. PMID 9339362
  4. A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system. Donohue PJ, et al. Brain Res Mol Brain Res, 1998 Feb. PMID 9526070
  5. Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress. Kubota K, et al. J Neurochem, 2006 Jun. PMID 16539653

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
    Title: GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
  2. Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer.
    Title: Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer.
  3. GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma.
    Title: GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma.
  4. Ecto-GPR37: a potential biomarker for Parkinson's disease.
    Title: Ecto-GPR37: a potential biomarker for Parkinson's disease.
  5. An interaction between GPR37 and both splice forms of D2R was detected.
    Title: GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells.
  6. Up-regulation of GPR37 promotes the proliferation of human glioma U251 cells
    Title: [Up-regulation of GPR37 promotes the proliferation of human glioma U251 cells].
  7. Study supports the idea that protein levels of parkin associated endothelin like receptor are likely regulated by a multitude of proteins including parkin, protein kinase C interacting protein and gamma-aminobutyrate type A receptor associated protein like 2 via mechanisms that include ubiquitination, proteasomal degradagtion and autophagy.
    Title: A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease.
  8. REG4 promotes peritoneal metastasis of gastric cancer through GPR37 and triggers a positive feedback loop.
    Title: REG4 promotes peritoneal metastasis of gastric cancer through GPR37.
  9. GPR37 was shown to be a component of the CASPR2-MUPP1 complex in brain.
    Title: CASPR2 forms a complex with GPR37 via MUPP1 but not with GPR37(R558Q), an autism spectrum disorder-related mutation.
  10. GPR37 may play an important role in the pathogenesis of hepatocellular carcinoma by affecting the proliferation of HCC cells.
    Title: A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study for reading and language abilities in two population cohorts.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled peptide receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables neuropeptide binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables neuropeptide receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables prosaposin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prosaposin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to reactive oxygen species ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
  
involved_in dopamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotion involved in locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
prosaposin receptor GPR37
Names
ETBR-LP-1
G protein-coupled receptor 37 (endothelin receptor type B-like)
Parkin-associated endothelin receptor-like receptor
endothelin B receptor-like protein 1
probable G-protein coupled receptor 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005302.5 → NP_005293.1  prosaposin receptor GPR37 precursor

    See identical proteins and their annotated locations for NP_005293.1

    Status: REVIEWED

    Source sequence(s)
    AC004925, AF017262
    Consensus CDS
    CCDS5792.1
    UniProtKB/Swiss-Prot
    A4D0Y6, O00348, O14768, O15354, Q8TD39
    Related
    ENSP00000306449.2, ENST00000303921.3
    Conserved Domains (1) summary
    cd15127
    Location:262 → 560
    7tmA_GPR37; G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    124743885..124765792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    126061240..126083145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15354.2 GenPept UniProtKB/Swiss-Prot:O15354

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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