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LSMEM1 leucine rich single-pass membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 286006, updated on 2-Nov-2024

Summary

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Official Symbol
LSMEM1provided by HGNC
Official Full Name
leucine rich single-pass membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:22036
See related
Ensembl:ENSG00000181016 AllianceGenome:HGNC:22036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C7orf53
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See LSMEM1 in Genome Data Viewer
Location:
7q31.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (112480304..112491062)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (113797449..113809353)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (112120908..112131117)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375457 Neighboring gene Sharpr-MPRA regulatory region 10411 Neighboring gene interferon related developmental regulator 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112089605-112090422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112090423-112091240 Neighboring gene uncharacterized LOC128031837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26513 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:112136767-112136980 Neighboring gene nucleophosmin 1 pseudogene 14 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:112181860-112182047 Neighboring gene long intergenic non-protein coding RNA 3076

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549
  2. Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205, Free PMC Article
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39575, MGC42850, MGC161427, MGC163440

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich single-pass membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134468.2 → NP_001127940.1  leucine-rich single-pass membrane protein 1

    See identical proteins and their annotated locations for NP_001127940.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AA121517, AC005192, BC126149, DB456503
    Consensus CDS
    CCDS5756.1
    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Related
    ENSP00000389278.2, ENST00000439068.6
    Conserved Domains (1) summary
    pfam15145
    Location:1 → 131
    DUF4577; Domain of unknown function (DUF4577)

  2. NM_182597.3 → NP_872403.1  leucine-rich single-pass membrane protein 1

    See identical proteins and their annotated locations for NP_872403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AA121517, AC005192, BC126149, DA894907, DA898266
    Consensus CDS
    CCDS5756.1
    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Related
    ENSP00000323304.3, ENST00000312849.4
    Conserved Domains (1) summary
    pfam15145
    Location:1 → 131
    DUF4577; Domain of unknown function (DUF4577)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    112480304..112491062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012028.3 → XP_016867517.1  leucine-rich single-pass membrane protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Conserved Domains (1) summary
    pfam15145
    Location:1 → 131
    DUF4577; Domain of unknown function (DUF4577)

  2. XM_011516074.3 → XP_011514376.1  leucine-rich single-pass membrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514376.1

    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Conserved Domains (1) summary
    pfam15145
    Location:1 → 131
    DUF4577; Domain of unknown function (DUF4577)

  3. XM_011516076.3 → XP_011514378.1  leucine-rich single-pass membrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514378.1

    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Conserved Domains (1) summary
    pfam15145
    Location:1 → 131
    DUF4577; Domain of unknown function (DUF4577)

  4. XM_011516075.3 → XP_011514377.1  leucine-rich single-pass membrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514377.1

    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Conserved Domains (1) summary
    pfam15145
    Location:1 → 131
    DUF4577; Domain of unknown function (DUF4577)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    113797449..113809353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357948.1 → XP_054213923.1  leucine-rich single-pass membrane protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7

  2. XM_054357950.1 → XP_054213925.1  leucine-rich single-pass membrane protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7

  3. XM_054357949.1 → XP_054213924.1  leucine-rich single-pass membrane protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N8F7.1 GenPept UniProtKB/Swiss-Prot:Q8N8F7

Gene LinkOut

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