U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LSMEM1 leucine rich single-pass membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 286006, updated on 22-Sep-2022

Summary

Official Symbol
LSMEM1provided by HGNC
Official Full Name
leucine rich single-pass membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:22036
See related
Ensembl:ENSG00000181016 AllianceGenome:HGNC:22036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C7orf53
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
7q31.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (112480304..112491062)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (113799155..113809353)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (112120908..112131117)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375456 Neighboring gene MT-CYB pseudogene 24 Neighboring gene uncharacterized LOC105375457 Neighboring gene Sharpr-MPRA regulatory region 10411 Neighboring gene interferon related developmental regulator 1 Neighboring gene nucleophosmin 1 pseudogene 14 Neighboring gene uncharacterized LOC100996249

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39575, MGC42850, MGC161427, MGC163440

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich single-pass membrane protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134468.2NP_001127940.1  leucine-rich single-pass membrane protein 1

    See identical proteins and their annotated locations for NP_001127940.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AA121517, AC005192, BC126149, DB456503
    Consensus CDS
    CCDS5756.1
    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Related
    ENSP00000389278.2, ENST00000439068.6
    Conserved Domains (1) summary
    pfam15145
    Location:1131
    DUF4577; Domain of unknown function (DUF4577)
  2. NM_182597.3NP_872403.1  leucine-rich single-pass membrane protein 1

    See identical proteins and their annotated locations for NP_872403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AA121517, AC005192, BC126149, DA894907, DA898266
    Consensus CDS
    CCDS5756.1
    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Related
    ENSP00000323304.3, ENST00000312849.4
    Conserved Domains (1) summary
    pfam15145
    Location:1131
    DUF4577; Domain of unknown function (DUF4577)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    112480304..112491062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012028.3XP_016867517.1  leucine-rich single-pass membrane protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Conserved Domains (1) summary
    pfam15145
    Location:1131
    DUF4577; Domain of unknown function (DUF4577)
  2. XM_011516074.3XP_011514376.1  leucine-rich single-pass membrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514376.1

    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Conserved Domains (1) summary
    pfam15145
    Location:1131
    DUF4577; Domain of unknown function (DUF4577)
  3. XM_011516076.3XP_011514378.1  leucine-rich single-pass membrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514378.1

    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Conserved Domains (1) summary
    pfam15145
    Location:1131
    DUF4577; Domain of unknown function (DUF4577)
  4. XM_011516075.3XP_011514377.1  leucine-rich single-pass membrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514377.1

    UniProtKB/Swiss-Prot
    Q49AR6, Q8N8F7
    Conserved Domains (1) summary
    pfam15145
    Location:1131
    DUF4577; Domain of unknown function (DUF4577)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    113799155..113809353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)