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ALKAL2 ALK and LTK ligand 2 [ Homo sapiens (human) ]

Gene ID: 285016, updated on 12-Aug-2022

Summary

Official Symbol
ALKAL2provided by HGNC
Official Full Name
ALK and LTK ligand 2provided by HGNC
Primary source
HGNC:HGNC:27683
See related
Ensembl:ENSG00000189292 MIM:619671; AllianceGenome:HGNC:27683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AUGA; FAM150B; PRO1097; RGPG542
Summary
Enables receptor signaling protein tyrosine kinase activator activity and receptor tyrosine kinase binding activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of ERK5 cascade; and positive regulation of neuron projection development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal (RPKM 46.6), ovary (RPKM 14.2) and 6 other tissues See more
Orthologs
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Genomic context

See ALKAL2 in Genome Data Viewer
Location:
2p25.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (279558..288091, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (279817..288348, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (279558..288091, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SH3 and SYLF domain containing 1 Neighboring gene acid phosphatase 1 Neighboring gene uncharacterized LOC101927262 Neighboring gene uncharacterized LOC105373346 Neighboring gene long intergenic non-protein coding RNA 1865

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor signaling protein tyrosine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables receptor signaling protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables receptor tyrosine kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ALK and LTK ligand 2
Names
AUG-alpha
augmentor alpha
augmentor-beta
family with sequence similarity 150 member B
protein FAM150B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002919.3NP_001002919.2  ALK and LTK ligand 2 precursor

    See identical proteins and their annotated locations for NP_001002919.2

    Status: VALIDATED

    Source sequence(s)
    AC079779, AI300876, BC033490
    Consensus CDS
    CCDS46218.1
    UniProtKB/Swiss-Prot
    B5MC76, Q6UX46
    Related
    ENSP00000384604.3, ENST00000403610.9
    Conserved Domains (1) summary
    pfam15129
    Location:35149
    FAM150; FAM150 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    279558..288091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443982.1XP_047299938.1  ALK and LTK ligand 2 isoform X3

  2. XM_047443981.1XP_047299937.1  ALK and LTK ligand 2 isoform X2

  3. XM_047443980.1XP_047299936.1  ALK and LTK ligand 2 isoform X1

    UniProtKB/TrEMBL
    A0A0B4J1W8
    Related
    ENSP00000389939.1, ENST00000452023.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    279817..288348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)