U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SIRPB2 signal regulatory protein beta 2 [ Homo sapiens (human) ]

Gene ID: 284759, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
SIRPB2provided by HGNC
Official Full Name
signal regulatory protein beta 2provided by HGNC
Primary source
HGNC:HGNC:16247
See related
Ensembl:ENSG00000196209 AllianceGenome:HGNC:16247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPN1L; PTPNS1L3; dJ776F14.2
Summary
Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in appendix (RPKM 5.0), placenta (RPKM 2.4) and 14 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SIRPB2 in Genome Data Viewer
Location:
20p13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (1470685..1491420, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (1519882..1540613, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1455223..1472066, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372497 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:1396577-1397776 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:1408109-1408868 Neighboring gene NSFL1 cofactor Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:1446723-1447224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12593 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:1458844-1460043 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:1481226-1481777 Neighboring gene uncharacterized LOC105372499 Neighboring gene uncharacterized LOC105372498 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:1501740-1502939 Neighboring gene RNA, U6 small nuclear 917, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SIRPB1 promotes prostate cancer cell proliferation via Akt activation. Song Q, et al. Prostate, 2020 Mar. PMID 31905248, Free PMC Article
  2. Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation. Nyati MK, et al. Cancer Res, 2006 Dec 15. PMID 17178844
  3. The SIRP family of receptors and immune regulation. Barclay AN, et al. Nat Rev Immunol, 2006 Jun. PMID 16691243
  4. Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags. Chen J, et al. Proc Natl Acad Sci U S A, 2002 Sep 17. PMID 12213963, Free PMC Article
  5. A nomenclature for signal regulatory protein family members. van den Berg TK, et al. J Immunol, 2005 Dec 15. PMID 16339511

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
signal-regulatory protein beta-2
Names
SIRP-beta-2
protein tyrosine phosphatase non-receptor type substrate protein
protein tyrosine phosphatase, non-receptor type substrate 1-like 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122962.2 → NP_001116434.1  signal-regulatory protein beta-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001116434.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK095499, AL109658, AY424277, BG539998, BM285394, DC313096, DC358609
    Consensus CDS
    CCDS42849.1
    UniProtKB/Swiss-Prot
    B4DLM9, E9PCW6, Q5JXA9, Q6TCH9
    UniProtKB/TrEMBL
    B3KTG0
    Related
    ENSP00000352849.3, ENST00000359801.8
    Conserved Domains (2) summary
    smart00410
    Location:46 → 149
    IG_like; Immunoglobulin like
    pfam07686
    Location:163 → 263
    V-set; Immunoglobulin V-set domain

  2. NM_001134836.2 → NP_001128308.1  signal-regulatory protein beta-2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to version 1, that results in a shorter protein (isoform 2) that lacks one of two immunoglobulin domains, when compared to isoform 1.
    Source sequence(s)
    AK095499, AK297072, AL109658
    Consensus CDS
    CCDS46570.1
    UniProtKB/Swiss-Prot
    Q5JXA9
    UniProtKB/TrEMBL
    B3KTG0
    Related
    ENSP00000402438.1, ENST00000444444.2
    Conserved Domains (2) summary
    smart00410
    Location:70 → 145
    IG_like; Immunoglobulin like
    pfam07686
    Location:65 → 165
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    1470685..1491420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440129.1 → XP_047296085.1  signal-regulatory protein beta-2 isoform X4

    UniProtKB/TrEMBL
    F2Z2Y9
    Related
    ENSP00000435045.1, ENST00000486775.5

  2. XM_005260709.4 → XP_005260766.1  signal-regulatory protein beta-2 isoform X6

    UniProtKB/TrEMBL
    B7Z281
    Conserved Domains (2) summary
    smart00410
    Location:70 → 145
    IG_like; Immunoglobulin like
    pfam07686
    Location:65 → 165
    V-set; Immunoglobulin V-set domain

  3. XM_005260708.5 → XP_005260765.1  signal-regulatory protein beta-2 isoform X2

    UniProtKB/TrEMBL
    B3KTG0
    Conserved Domains (2) summary
    smart00410
    Location:46 → 149
    IG_like; Immunoglobulin like
    pfam07686
    Location:163 → 263
    V-set; Immunoglobulin V-set domain

  4. XM_047440130.1 → XP_047296086.1  signal-regulatory protein beta-2 isoform X5

  5. XM_047440127.1 → XP_047296083.1  signal-regulatory protein beta-2 isoform X1

  6. XM_047440128.1 → XP_047296084.1  signal-regulatory protein beta-2 isoform X3

RNA

  1. XR_007067453.1 RNA Sequence

  2. XR_007067452.1 RNA Sequence

  3. XR_007067451.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    1519882..1540613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323392.1 → XP_054179367.1  signal-regulatory protein beta-2 isoform X4

  2. XM_054323394.1 → XP_054179369.1  signal-regulatory protein beta-2 isoform X6

  3. XM_054323390.1 → XP_054179365.1  signal-regulatory protein beta-2 isoform X2

  4. XM_054323393.1 → XP_054179368.1  signal-regulatory protein beta-2 isoform X5

  5. XM_054323389.1 → XP_054179364.1  signal-regulatory protein beta-2 isoform X1

  6. XM_054323391.1 → XP_054179366.1  signal-regulatory protein beta-2 isoform X3

RNA

  1. XR_008485256.1 RNA Sequence

  2. XR_008485255.1 RNA Sequence

  3. XR_008485254.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_021484.1: Suppressed sequence

    Description
    NR_021484.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JXA9.1 GenPept UniProtKB/Swiss-Prot:Q5JXA9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools