Format

Send to:

Choose Destination

SIRPB2 signal regulatory protein beta 2 [ Homo sapiens (human) ]

Gene ID: 284759, updated on 23-Nov-2021

Summary

Official Symbol
SIRPB2provided by HGNC
Official Full Name
signal regulatory protein beta 2provided by HGNC
Primary source
HGNC:HGNC:16247
See related
Ensembl:ENSG00000196209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPN1L; PTPNS1L3; dJ776F14.2
Expression
Broad expression in appendix (RPKM 5.0), placenta (RPKM 2.4) and 14 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SIRPB2 in Genome Data Viewer
Location:
20p13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (1474578..1491762, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1455223..1472066, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372497 Neighboring gene NSFL1 cofactor Neighboring gene uncharacterized LOC105372499 Neighboring gene uncharacterized LOC105372498 Neighboring gene RNA, U6 small nuclear 917, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
signal-regulatory protein beta-2
Names
SIRP-beta-2
protein tyrosine phosphatase non-receptor type substrate protein
protein tyrosine phosphatase, non-receptor type substrate 1-like 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122962.2NP_001116434.1  signal-regulatory protein beta-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001116434.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK095499, AL109658, AY424277, BG539998, BM285394, DC313096, DC358609
    Consensus CDS
    CCDS42849.1
    UniProtKB/Swiss-Prot
    Q5JXA9
    UniProtKB/TrEMBL
    B3KTG0
    Related
    ENSP00000352849.3, ENST00000359801.8
    Conserved Domains (2) summary
    smart00410
    Location:46149
    IG_like; Immunoglobulin like
    pfam07686
    Location:163263
    V-set; Immunoglobulin V-set domain
  2. NM_001134836.2NP_001128308.1  signal-regulatory protein beta-2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to version 1, that results in a shorter protein (isoform 2) that lacks one of two immunoglobulin domains, when compared to isoform 1.
    Source sequence(s)
    AK095499, AK297072, AL109658
    Consensus CDS
    CCDS46570.1
    UniProtKB/Swiss-Prot
    Q5JXA9
    UniProtKB/TrEMBL
    B3KTG0
    Related
    ENSP00000402438.1, ENST00000444444.2
    Conserved Domains (2) summary
    smart00410
    Location:70145
    IG_like; Immunoglobulin like
    pfam07686
    Location:65165
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    1474578..1491762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529223.2XP_011527525.1  signal-regulatory protein beta-2 isoform X4

    See identical proteins and their annotated locations for XP_011527525.1

    Conserved Domains (2) summary
    smart00410
    Location:30105
    IG_like; Immunoglobulin like
    pfam07686
    Location:25125
    V-set; Immunoglobulin V-set domain
  2. XM_005260709.3XP_005260766.1  signal-regulatory protein beta-2 isoform X3

    Conserved Domains (2) summary
    smart00410
    Location:70145
    IG_like; Immunoglobulin like
    pfam07686
    Location:65165
    V-set; Immunoglobulin V-set domain
  3. XM_005260708.4XP_005260765.1  signal-regulatory protein beta-2 isoform X1

    Related
    ENSP00000435045.1, ENST00000486775.5
    Conserved Domains (2) summary
    smart00410
    Location:46149
    IG_like; Immunoglobulin like
    pfam07686
    Location:163263
    V-set; Immunoglobulin V-set domain
  4. XM_011529221.2XP_011527523.1  signal-regulatory protein beta-2 isoform X2

    Conserved Domains (2) summary
    smart00410
    Location:1102
    IG_like; Immunoglobulin like
    pfam07686
    Location:116216
    V-set; Immunoglobulin V-set domain
  5. XM_011529224.2XP_011527526.1  signal-regulatory protein beta-2 isoform X4

    See identical proteins and their annotated locations for XP_011527526.1

    Conserved Domains (2) summary
    smart00410
    Location:30105
    IG_like; Immunoglobulin like
    pfam07686
    Location:25125
    V-set; Immunoglobulin V-set domain
  6. XM_011529225.2XP_011527527.1  signal-regulatory protein beta-2 isoform X5

    Conserved Domains (2) summary
    smart00410
    Location:2196
    IG_like; Immunoglobulin like
    pfam07686
    Location:16116
    V-set; Immunoglobulin V-set domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_021484.1: Suppressed sequence

    Description
    NR_021484.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Support Center