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CYP4A22 cytochrome P450 family 4 subfamily A member 22 [ Homo sapiens (human) ]

Gene ID: 284541, updated on 5-Aug-2018

Summary

Official Symbol
CYP4A22provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily A member 22provided by HGNC
Primary source
HGNC:HGNC:20575
See related
Ensembl:ENSG00000162365 MIM:615341; Vega:OTTHUMG00000007845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression
Biased expression in liver (RPKM 60.8) and kidney (RPKM 24.2) See more
Orthologs

Genomic context

See CYP4A22 in Genome Data Viewer
Location:
1p33
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (47137425..47149738)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47603107..47614528)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily X member 1 Neighboring gene cytochrome P450 family 4 subfamily A member 44, pseudogene Neighboring gene cytochrome P450 family 4 subfamily Z member 1 Neighboring gene tubulin alpha 1c pseudogene Neighboring gene uncharacterized LOC105378701 Neighboring gene MT-ND1 pseudogene 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Cytochrome P450 - arranged by substrate type, organism-specific biosystem (from REACTOME)
    Cytochrome P450 - arranged by substrate type, organism-specific biosystemThe P450 isozyme system is the major phase 1 biotransforming system in man, accounting for more than 90% of drug biotransformations. This system has huge catalytic versatility and a broad substrate s...
  • Eicosanoids, organism-specific biosystem (from REACTOME)
    Eicosanoids, organism-specific biosystemArachidonic acid is metabolized via three major enzymatic pathways: cyclooxygenase, lipoxygenase, and cytochrome P450. The cytochrome P450 pathway metabolites are oxygenated metabolites of arachidoni...
  • Fatty acid degradation, organism-specific biosystem (from KEGG)
    Fatty acid degradation, organism-specific biosystem
    Fatty acid degradation
  • Fatty acid degradation, conserved biosystem (from KEGG)
    Fatty acid degradation, conserved biosystem
    Fatty acid degradation
  • Fatty acids, organism-specific biosystem (from REACTOME)
    Fatty acids, organism-specific biosystemThe CYP4 family are the main CYPs involved in the metabolism of long-chain fatty acids.
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Miscellaneous substrates, organism-specific biosystem (from REACTOME)
    Miscellaneous substrates, organism-specific biosystemApproximately a quarter of the 57 human CYPs still remain "orphans" in the sense that their function, expression sites, and regulation are largely not elucidated. While there is enough experimental e...
  • Oxidation by Cytochrome P450, organism-specific biosystem (from WikiPathways)
    Oxidation by Cytochrome P450, organism-specific biosystemOxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
  • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
    Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
  • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
    Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
16-hydroxypalmitate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT arachidonic acid omega-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
laurate hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
lipid hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
NOT omega-hydroxylase P450 pathway IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
organelle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 4A22
Names
CYPIVA22
cytochrome P450 4A22K
cytochrome P450, family 4, subfamily A, polypeptide 22
fatty acid omega-hydroxylase
lauric acid omega-hydroxylase
long-chain fatty acid omega-monooxygenase
NP_001010969.2
NP_001295031.1
XP_005270824.1
XP_005270827.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007937.1 RefSeqGene

    Range
    4991..16420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001010969.3NP_001010969.2  cytochrome P450 4A22 isoform 1

    See identical proteins and their annotated locations for NP_001010969.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL135960, BC148248
    Consensus CDS
    CCDS30707.1
    UniProtKB/Swiss-Prot
    Q5TCH4
    Related
    ENSP00000360958.3, OTTHUMP00000009560, ENST00000371891.7, OTTHUMT00000021635
    Conserved Domains (1) summary
    pfam00067
    Location:52505
    p450; Cytochrome P450
  2. NM_001308102.1NP_001295031.1  cytochrome P450 4A22 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct internal region and has a shorter C-terminus than isoform 1.
    Source sequence(s)
    AL135960, BC142607, BC142690, BC148248
    Consensus CDS
    CCDS76160.1
    UniProtKB/Swiss-Prot
    Q5TCH4
    UniProtKB/TrEMBL
    A0A087WZX9, A5PKT5, A5PL05
    Related
    ENSP00000482952.1, ENST00000619754.4
    Conserved Domains (1) summary
    cl12078
    Location:52357
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    47137425..47149738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270767.3XP_005270824.1  cytochrome P450 4A22 isoform X1

    See identical proteins and their annotated locations for XP_005270824.1

    UniProtKB/TrEMBL
    Q5TCH5
    Related
    ENSP00000360957.3, OTTHUMP00000009562, ENST00000371890.7, OTTHUMT00000021637
    Conserved Domains (1) summary
    cl12078
    Location:52407
    p450; Cytochrome P450
  2. XM_005270770.3XP_005270827.1  cytochrome P450 4A22 isoform X2

    Conserved Domains (1) summary
    cl12078
    Location:52212
    p450; Cytochrome P450

RNA

  1. XR_001737122.1 RNA Sequence

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