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OR2L13 olfactory receptor family 2 subfamily L member 13 [ Homo sapiens (human) ]

Gene ID: 284521, updated on 2-Nov-2024

Summary

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Official Symbol
OR2L13provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily L member 13provided by HGNC
Primary source
HGNC:HGNC:19578
See related
Ensembl:ENSG00000196071 AllianceGenome:HGNC:19578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2L14
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See OR2L13 in Genome Data Viewer
Location:
1q44
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (247937177..248101163)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247363114..247527286)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248100479..248264465)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AJ member 1 Neighboring gene CDC like kinase 3 pseudogene 2 Neighboring gene olfactory receptor family 2 subfamily X member 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily L member 8 Neighboring gene olfactory receptor family 2 subfamily AK member 2 Neighboring gene olfactory receptor family 2 subfamily L member 9 pseudogene Neighboring gene olfactory receptor family 2 subfamily L member 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily L member 6 pseudogene Neighboring gene olfactory receptor family 2 subfamily L member 5 Neighboring gene uncharacterized LOC105373275 Neighboring gene olfactory receptor family 2 subfamily L member 2 Neighboring gene olfactory receptor family 2 subfamily L member 3 Neighboring gene olfactory receptor family 2 subfamily T member 32 pseudogene Neighboring gene olfactory receptor family 2 subfamily M member 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily M member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms. Morrell CN, et al. J Clin Invest, 2022 May 2. PMID 35324479, Free PMC Article
  2. Maternal 5(m)CpG Imprints at the PARD6G-AS1 and GCSAML Differentially Methylated Regions Are Decoupled From Parent-of-Origin Expression Effects in Multiple Human Tissues. de Sá Machado Araújo G, et al. Front Genet, 2018. PMID 29545821, Free PMC Article
  3. Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system. Naz RK, et al. J Reprod Immunol, 2010 Jan. PMID 19945174, Free PMC Article
  4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms.
    Title: Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms.
  2. RNA-Seq evidence of testis-specific monoallelic expression of OR2L13, located 419 kb downstream of the GCSAML somatic (secondary), imprinted differentially methylated region (iDMR). OR2L13 has a predicted CGI-bearing allelically methylated region overlapping the promoter region in blood, spleen, lung, liver, esophagus, and brain, but hypomethylated in gamete, blastocyst, placenta, thymus, and spinal cord methylomes.
    Title: Maternal 5(m)CpG Imprints at the PARD6G-AS1 and GCSAML Differentially Methylated Regions Are Decoupled From Parent-of-Origin Expression Effects in Multiple Human Tissues.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC40047

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
olfactory receptor 2L13
Names
olfactory receptor 2L14
olfactory receptor, family 2, subfamily L, member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304535.3 → NP_001291464.1  olfactory receptor 2L13

    See identical proteins and their annotated locations for NP_001291464.1

    Status: VALIDATED

    Source sequence(s)
    AC099571, AL513488
    Consensus CDS
    CCDS1637.1
    UniProtKB/Swiss-Prot
    Q5VUR5, Q8N349
    UniProtKB/TrEMBL
    A0A126GW96
    Conserved Domains (1) summary
    cd15421
    Location:37 → 300
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001395936.1 → NP_001382865.1  olfactory receptor 2L13

    Status: VALIDATED

    Source sequence(s)
    AL513488
    Consensus CDS
    CCDS1637.1
    UniProtKB/Swiss-Prot
    Q5VUR5, Q8N349
    UniProtKB/TrEMBL
    A0A126GW96
    Related
    ENSP00000350836.2, ENST00000358120.4
    Conserved Domains (1) summary
    cd15421
    Location:37 → 300
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_175911.5 → NP_787107.1  olfactory receptor 2L13

    See identical proteins and their annotated locations for NP_787107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC099571, AL513488
    Consensus CDS
    CCDS1637.1
    UniProtKB/Swiss-Prot
    Q5VUR5, Q8N349
    UniProtKB/TrEMBL
    A0A126GW96
    Conserved Domains (1) summary
    cd15421
    Location:37 → 300
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    247937177..248101163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544169.3 → XP_011542471.1  olfactory receptor 2L13 isoform X1

    See identical proteins and their annotated locations for XP_011542471.1

    UniProtKB/Swiss-Prot
    Q5VUR5, Q8N349
    UniProtKB/TrEMBL
    A0A126GW96
    Conserved Domains (1) summary
    cd15421
    Location:37 → 300
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    247363114..247527286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336108.1 → XP_054192083.1  olfactory receptor 2L13 isoform X1

    UniProtKB/Swiss-Prot
    Q5VUR5, Q8N349
    UniProtKB/TrEMBL
    A0A126GW96
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N349.1 GenPept UniProtKB/Swiss-Prot:Q8N349

Gene LinkOut

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