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GPR22 G protein-coupled receptor 22 [ Homo sapiens (human) ]

Gene ID: 2845, updated on 22-Sep-2022

Summary

Official Symbol
GPR22provided by HGNC
Official Full Name
G protein-coupled receptor 22provided by HGNC
Primary source
HGNC:HGNC:4477
See related
Ensembl:ENSG00000172209 MIM:601910; AllianceGenome:HGNC:4477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 6.9), brain (RPKM 4.8) and 2 other tissues See more
Orthologs
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Genomic context

See GPR22 in Genome Data Viewer
Location:
7q22.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (107470057..107477845)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (108786096..108791724)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (107110502..107116129)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901721 Neighboring gene component of oligomeric golgi complex 5 Neighboring gene ribosomal protein L37a pseudogene 6 Neighboring gene DUS4L-BCAP29 readthrough Neighboring gene small nucleolar RNA U109 Neighboring gene dihydrouridine synthase 4 like Neighboring gene B cell receptor associated protein 29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129847

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
G-protein coupled receptor 22
Names
probable G-protein coupled receptor 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005295.3NP_005286.2  G-protein coupled receptor 22

    See identical proteins and their annotated locations for NP_005286.2

    Status: REVIEWED

    Source sequence(s)
    AC002381, AK122621, BC107128, DA519131, U66581
    Consensus CDS
    CCDS5744.1
    UniProtKB/Swiss-Prot
    O14554, Q99680
    UniProtKB/TrEMBL
    A4D0R8, B3KV13, Q3KNS9
    Related
    ENSP00000302676.4, ENST00000304402.6
    Conserved Domains (1) summary
    cd00637
    Location:44370
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    107470057..107477845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420214.1XP_047276170.1  G-protein coupled receptor 22 isoform X1

    UniProtKB/Swiss-Prot
    O14554
  2. XM_011516056.4XP_011514358.1  G-protein coupled receptor 22 isoform X1

    See identical proteins and their annotated locations for XP_011514358.1

    UniProtKB/Swiss-Prot
    O14554, Q99680
    UniProtKB/TrEMBL
    A4D0R8
    Conserved Domains (1) summary
    cd00637
    Location:44370
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_017852930.1 Reference GRCh38.p14 PATCHES

    Range
    315704..321332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    108786096..108791724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)