U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IGHV3-21 immunoglobulin heavy variable 3-21 [ Homo sapiens (human) ]

Gene ID: 28444, updated on 17-Jun-2024

Summary

Official Symbol
IGHV3-21provided by HGNC
Official Full Name
immunoglobulin heavy variable 3-21provided by HGNC
Primary source
HGNC:HGNC:5586
See related
Ensembl:ENSG00000211947 IMGT/GENE-DB:IGHV3-21; AllianceGenome:HGNC:5586
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VH; IGHV321
Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to be part of immunoglobulin complex, circulating. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See IGHV3-21 in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (106235062..106235515, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (100506581..100507034, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106691671..106692124, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy locus Neighboring gene immunoglobulin heavy variable (II)-20-1 (pseudogene) Neighboring gene ReSE screen-validated silencer GRCh37_chr14:106714469-106714636 Neighboring gene immunoglobulin heavy variable 3-20 Neighboring gene immunoglobulin heavy variable (II)-22-1 (pseudogene) Neighboring gene immunoglobulin heavy variable 3-22 (pseudogene)

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Other Names

  • immunogloblin heavy chain variable region

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
part_of immunoglobulin complex IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001019.6 

    Range
    644830..645283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    106235062..106235515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187600.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    702831..703284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    100506581..100507034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)