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TMEM150B transmembrane protein 150B [ Homo sapiens (human) ]

Gene ID: 284417, updated on 12-Oct-2019

Summary

Official Symbol
TMEM150Bprovided by HGNC
Official Full Name
transmembrane protein 150Bprovided by HGNC
Primary source
HGNC:HGNC:34415
See related
Ensembl:ENSG00000180061 MIM:617291
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTN2; DRAM3; TMEM224
Summary
This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Biased expression in duodenum (RPKM 9.7), small intestine (RPKM 9.3) and 7 other tissues See more
Orthologs

Genomic context

See TMEM150B in Genome Data Viewer
Location:
19q13.42
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (55308869..55334043, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55823653..55845416, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 1 Neighboring gene microRNA 6803 Neighboring gene HSPA (Hsp70) binding protein 1 Neighboring gene BR serine/threonine kinase 1 Neighboring gene lysine methyltransferase 5C Neighboring gene cytochrome c oxidase subunit 6B2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of early menopause and the combined impact of identified variants.
NHGRI GWA Catalog
Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
NHGRI GWA Catalog
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
 
regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
autophagosome membrane IEA
Inferred from Electronic Annotation
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
modulator of macroautophagy TMEM150B
Names
DRAM-Related/Associated Member 3
hCG1651476
protein DRAM-3
tentonin 2
transmembrane protein 224
transmembrane protein LOC284417

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085488.3NP_001078957.1  modulator of macroautophagy TMEM150B isoform a

    See identical proteins and their annotated locations for NP_001078957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AC020922, AU311823, BC171893
    Consensus CDS
    CCDS42629.1
    UniProtKB/Swiss-Prot
    A6NC51
    Conserved Domains (1) summary
    pfam10277
    Location:4206
    Frag1; Frag1/DRAM/Sfk1 family
  2. NM_001282011.2NP_001268940.1  modulator of macroautophagy TMEM150B isoform a

    See identical proteins and their annotated locations for NP_001268940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AC020922, AU311823, BC171904
    Consensus CDS
    CCDS42629.1
    UniProtKB/Swiss-Prot
    A6NC51
    Related
    ENSP00000320757.4, ENST00000326652.9
    Conserved Domains (1) summary
    pfam10277
    Location:4206
    Frag1; Frag1/DRAM/Sfk1 family

RNA

  1. NR_104066.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020922, AU311823, BC171901, BC171904
    Related
    ENST00000586609.5
  2. NR_104071.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020922, AU311823, BC171893
    Related
    ENST00000592603.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    55308869..55334043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526850.3XP_011525152.1  modulator of macroautophagy TMEM150B isoform X2

    Conserved Domains (1) summary
    pfam10277
    Location:4168
    Frag1; Frag1/DRAM/Sfk1 family
  2. XM_011526853.2XP_011525155.1  modulator of macroautophagy TMEM150B isoform X1

    See identical proteins and their annotated locations for XP_011525155.1

    UniProtKB/Swiss-Prot
    A6NC51
    Conserved Domains (1) summary
    pfam10277
    Location:4206
    Frag1; Frag1/DRAM/Sfk1 family
  3. XM_011526855.3XP_011525157.1  modulator of macroautophagy TMEM150B isoform X1

    See identical proteins and their annotated locations for XP_011525157.1

    UniProtKB/Swiss-Prot
    A6NC51
    Conserved Domains (1) summary
    pfam10277
    Location:4206
    Frag1; Frag1/DRAM/Sfk1 family
  4. XM_011526852.3XP_011525154.1  modulator of macroautophagy TMEM150B isoform X1

    See identical proteins and their annotated locations for XP_011525154.1

    UniProtKB/Swiss-Prot
    A6NC51
    Conserved Domains (1) summary
    pfam10277
    Location:4206
    Frag1; Frag1/DRAM/Sfk1 family
  5. XM_017026667.2XP_016882156.1  modulator of macroautophagy TMEM150B isoform X1

    UniProtKB/Swiss-Prot
    A6NC51
    Conserved Domains (1) summary
    pfam10277
    Location:4206
    Frag1; Frag1/DRAM/Sfk1 family
  6. XM_005258812.4XP_005258869.1  modulator of macroautophagy TMEM150B isoform X1

    See identical proteins and their annotated locations for XP_005258869.1

    UniProtKB/Swiss-Prot
    A6NC51
    Conserved Domains (1) summary
    pfam10277
    Location:4206
    Frag1; Frag1/DRAM/Sfk1 family
  7. XM_011526856.3XP_011525158.1  modulator of macroautophagy TMEM150B isoform X1

    See identical proteins and their annotated locations for XP_011525158.1

    UniProtKB/Swiss-Prot
    A6NC51
    Conserved Domains (1) summary
    pfam10277
    Location:4206
    Frag1; Frag1/DRAM/Sfk1 family
  8. XM_011526854.3XP_011525156.1  modulator of macroautophagy TMEM150B isoform X1

    See identical proteins and their annotated locations for XP_011525156.1

    UniProtKB/Swiss-Prot
    A6NC51
    Conserved Domains (1) summary
    pfam10277
    Location:4206
    Frag1; Frag1/DRAM/Sfk1 family
  9. XM_011526857.2XP_011525159.1  modulator of macroautophagy TMEM150B isoform X3

    Conserved Domains (1) summary
    pfam10277
    Location:1146
    Frag1; Frag1/DRAM/Sfk1 family
  10. XM_017026668.1XP_016882157.1  modulator of macroautophagy TMEM150B isoform X3

    Conserved Domains (1) summary
    pfam10277
    Location:1146
    Frag1; Frag1/DRAM/Sfk1 family
  11. XM_011526851.3XP_011525153.1  modulator of macroautophagy TMEM150B isoform X4

    Conserved Domains (1) summary
    pfam10277
    Location:4172
    Frag1; Frag1/DRAM/Sfk1 family
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