Format

Send to:

Choose Destination

LYPD5 LY6/PLAUR domain containing 5 [ Homo sapiens (human) ]

Gene ID: 284348, updated on 1-Jun-2020

Summary

Official Symbol
LYPD5provided by HGNC
Official Full Name
LY6/PLAUR domain containing 5provided by HGNC
Primary source
HGNC:HGNC:26397
See related
Ensembl:ENSG00000159871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO4356
Expression
Biased expression in skin (RPKM 12.1), brain (RPKM 2.5) and 5 other tissues See more
Orthologs

Genomic context

See LYPD5 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43795927..43820656, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44300079..44324808, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14970 Neighboring gene CRISPRi-validated cis-regulatory element chr19.4591 Neighboring gene zinc finger protein 283 Neighboring gene zinc finger protein 404

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog
The correlation between reading and mathematics ability at age twelve has a substantial genetic component.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30469

Gene Ontology Provided by GOA

Function Evidence Code Pubs
laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ly6/PLAUR domain-containing protein 5
Names
metastasis-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031749.3NP_001026919.2  ly6/PLAUR domain-containing protein 5 isoform A precursor

    See identical proteins and their annotated locations for NP_001026919.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) encodes the longer protein (isoform A).
    Source sequence(s)
    AC115522, AY358719, BC044237, BC057816, CF529795, DC364960
    Consensus CDS
    CCDS46096.1
    UniProtKB/Swiss-Prot
    Q6UWN5
    Related
    ENSP00000367185.2, ENST00000377950.8
    Conserved Domains (1) summary
    pfam00021
    Location:135214
    UPAR_LY6; u-PAR/Ly-6 domain
  2. NM_001288763.1NP_001275692.1  ly6/PLAUR domain-containing protein 5 isoform B

    See identical proteins and their annotated locations for NP_001275692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded protein (isoform B) has a distinct N-terminus and is shorter than isoform A. Variants B and C encode the same protein.
    Source sequence(s)
    AC115522, BC044237, CF529795, CK823626, DA093306
    Consensus CDS
    CCDS12631.1
    UniProtKB/Swiss-Prot
    Q6UWN5
    Related
    ENSP00000471692.1, ENST00000594013.5
    Conserved Domains (1) summary
    pfam00021
    Location:92171
    UPAR_LY6; u-PAR/Ly-6 domain
  3. NM_182573.2NP_872379.2  ly6/PLAUR domain-containing protein 5 isoform B

    See identical proteins and their annotated locations for NP_872379.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded protein (isoform B) has a distinct N-terminus and is shorter than isoform A. Variants B and C encode the same protein.
    Source sequence(s)
    AC115522, BC044237, CF529795, DA286806
    Consensus CDS
    CCDS12631.1
    UniProtKB/Swiss-Prot
    Q6UWN5
    Related
    ENSP00000408433.1, ENST00000414615.6
    Conserved Domains (1) summary
    pfam00021
    Location:92171
    UPAR_LY6; u-PAR/Ly-6 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43795927..43820656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center