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VMO1 vitelline membrane outer layer 1 homolog [ Homo sapiens (human) ]

Gene ID: 284013, updated on 5-Jul-2025
Official Symbol
VMO1provided by HGNC
Official Full Name
vitelline membrane outer layer 1 homologprovided by HGNC
Primary source
HGNC:HGNC:30387
See related
Ensembl:ENSG00000182853 MIM:621110; AllianceGenome:HGNC:30387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERGA6350; PRO21055
Summary
Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in spleen (RPKM 5.3), lung (RPKM 3.3) and 24 other tissues See more
Orthologs
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See VMO1 in Genome Data Viewer
Location:
17p13.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4785285..4786364, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4674933..4676011, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4688580..4689659, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4642642-4643546 Neighboring gene zinc finger MYND-type containing 15 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:4667359-4667521 Neighboring gene transmembrane 4 L six family member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11548 Neighboring gene glycolipid transfer protein domain containing 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:4699218-4699816 Neighboring gene proteasome 20S subunit beta 6

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Preferred Names
vitelline membrane outer layer protein 1 homolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144939.2NP_001138411.1  vitelline membrane outer layer protein 1 homolog isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at the 3' end of exon 2, compared to variant 1. This difference results in a frameshift and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BI836994, CD367473
    Consensus CDS
    CCDS45587.1
    UniProtKB/Swiss-Prot
    Q7Z5L0
    Related
    ENSP00000408166.2, ENST00000441199.2
    Conserved Domains (1) summary
    cd00220
    Location:35106
    VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...
  2. NM_001144940.2NP_001138412.1  vitelline membrane outer layer protein 1 homolog isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at the 3' end of exon 2, compared to variant 1. This difference results in a frameshift and a protein (isoform 3) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC104195, BI836994, CD367284
    Consensus CDS
    CCDS45586.1
    UniProtKB/Swiss-Prot
    Q7Z5L0
    Related
    ENSP00000390450.2, ENST00000416307.6
    Conserved Domains (1) summary
    cd00220
    Location:3591
    VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...
  3. NM_001144941.2NP_001138413.1  vitelline membrane outer layer protein 1 homolog isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region, compared to variant 1. This difference results in a frameshift and a protein (isoform 4) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BI836994, CD367473
    Consensus CDS
    CCDS45585.1
    UniProtKB/Swiss-Prot
    Q7Z5L0
    Related
    ENSP00000346133.4, ENST00000354194.4
    Conserved Domains (1) summary
    cd00220
    Location:3565
    VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...
  4. NM_182566.3NP_872372.1  vitelline membrane outer layer protein 1 homolog isoform 1 precursor

    See identical proteins and their annotated locations for NP_872372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC104195, CD367284
    Consensus CDS
    CCDS11055.1
    UniProtKB/Swiss-Prot
    C9JQ15, E9PAU9, E9PGP4, Q3SXP1, Q7Z5L0, Q8IUY1
    Related
    ENSP00000328397.5, ENST00000328739.6
    Conserved Domains (1) summary
    pfam03762
    Location:36200
    VOMI; Vitelline membrane outer layer protein I (VOMI)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    4785285..4786364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    4674933..4676011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)