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VMO1 vitelline membrane outer layer 1 homolog [ Homo sapiens (human) ]

Gene ID: 284013, updated on 23-Nov-2021

Summary

Official Symbol
VMO1provided by HGNC
Official Full Name
vitelline membrane outer layer 1 homologprovided by HGNC
Primary source
HGNC:HGNC:30387
See related
Ensembl:ENSG00000182853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERGA6350; PRO21055
Expression
Broad expression in spleen (RPKM 5.3), lung (RPKM 3.3) and 24 other tissues See more
Orthologs
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Genomic context

See VMO1 in Genome Data Viewer
Location:
17p13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (4785285..4786364, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4688580..4689659, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene zinc finger MYND-type containing 15 Neighboring gene transmembrane 4 L six family member 5 Neighboring gene glycolipid transfer protein domain containing 2 Neighboring gene proteasome 20S subunit beta 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • MGC125880, MGC125881

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
vitelline membrane outer layer protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144939.2NP_001138411.1  vitelline membrane outer layer protein 1 homolog isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at the 3' end of exon 2, compared to variant 1. This difference results in a frameshift and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BI836994, CD367473
    Consensus CDS
    CCDS45587.1
    UniProtKB/Swiss-Prot
    Q7Z5L0
    Related
    ENSP00000408166.2, ENST00000441199.2
    Conserved Domains (1) summary
    cd00220
    Location:35106
    VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...
  2. NM_001144940.2NP_001138412.1  vitelline membrane outer layer protein 1 homolog isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at the 3' end of exon 2, compared to variant 1. This difference results in a frameshift and a protein (isoform 3) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC104195, BI836994, CD367284
    Consensus CDS
    CCDS45586.1
    UniProtKB/Swiss-Prot
    Q7Z5L0
    Related
    ENSP00000390450.2, ENST00000416307.6
    Conserved Domains (1) summary
    cd00220
    Location:3591
    VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...
  3. NM_001144941.2NP_001138413.1  vitelline membrane outer layer protein 1 homolog isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region, compared to variant 1. This difference results in a frameshift and a protein (isoform 4) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BI836994, CD367473
    Consensus CDS
    CCDS45585.1
    UniProtKB/Swiss-Prot
    Q7Z5L0
    Related
    ENSP00000346133.4, ENST00000354194.4
    Conserved Domains (1) summary
    cd00220
    Location:3565
    VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...
  4. NM_182566.3NP_872372.1  vitelline membrane outer layer protein 1 homolog isoform 1 precursor

    See identical proteins and their annotated locations for NP_872372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC104195, CD367284
    Consensus CDS
    CCDS11055.1
    UniProtKB/Swiss-Prot
    Q7Z5L0
    Related
    ENSP00000328397.5, ENST00000328739.6
    Conserved Domains (1) summary
    pfam03762
    Location:36200
    VOMI; Vitelline membrane outer layer protein I (VOMI)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    4785285..4786364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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