U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR17 G protein-coupled receptor 17 [ Homo sapiens (human) ]

Gene ID: 2840, updated on 23-Nov-2023

Summary

Official Symbol
GPR17provided by HGNC
Official Full Name
G protein-coupled receptor 17provided by HGNC
Primary source
HGNC:HGNC:4471
See related
Ensembl:ENSG00000144230 MIM:603071; AllianceGenome:HGNC:4471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within negative regulation of inflammatory response to antigenic stimulus. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 16.2), endometrium (RPKM 2.8) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GPR17 in Genome Data Viewer
Location:
2q14.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (127646153..127652639)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (128081407..128087893)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128403728..128410213)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373609 Neighboring gene myosin VIIB Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128335179-128335732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16497 Neighboring gene uncharacterized LOC101927834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128393428-128394374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128394375-128395321 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128395322-128396268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128396269-128397214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128406535-128407262 Neighboring gene Sharpr-MPRA regulatory region 7437 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128407989-128408715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128408716-128409441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128416288-128416788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128419363-128420360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128420398-128420938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128420939-128421478 Neighboring gene LIM zinc finger domain containing 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:128457593-128458792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11936 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:128478937-128480136 Neighboring gene SFT2 domain containing 3 Neighboring gene WD repeat domain 33 Neighboring gene MPRA-validated peak3854 silencer Neighboring gene MPRA-validated peak3855 silencer Neighboring gene MPRA-validated peak3856 silencer Neighboring gene MPRA-validated peak3857 silencer Neighboring gene RNY4 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp686M18273

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chemokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables receptor serine/threonine kinase binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
uracil nucleotide/cysteinyl leukotriene receptor
Names
P2Y-like receptor
R12
UDP/CysLT receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161415.2NP_001154887.1  uracil nucleotide/cysteinyl leukotriene receptor isoform a

    See identical proteins and their annotated locations for NP_001154887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC039595, DA314295, DA366480
    Consensus CDS
    CCDS2148.1
    UniProtKB/Swiss-Prot
    A8K9L0, B2R9X0, Q13304, Q8N5S7, Q9UDZ6, Q9UE21
    UniProtKB/TrEMBL
    B3KX68
    Related
    ENSP00000442982.1, ENST00000544369.5
    Conserved Domains (1) summary
    cd15161
    Location:60336
    7tmA_GPR17; G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001161416.2NP_001154888.1  uracil nucleotide/cysteinyl leukotriene receptor isoform b

    See identical proteins and their annotated locations for NP_001154888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    BC039595, DA366480
    Consensus CDS
    CCDS92862.1
    UniProtKB/TrEMBL
    B3KX68, G4XH68
    Conserved Domains (1) summary
    pfam00001
    Location:48297
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_001161417.2NP_001154889.1  uracil nucleotide/cysteinyl leukotriene receptor isoform b

    See identical proteins and their annotated locations for NP_001154889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AK292725, BC039595
    Consensus CDS
    CCDS92862.1
    UniProtKB/TrEMBL
    B3KX68, G4XH68
    Related
    ENSP00000508383.1, ENST00000486700.2
    Conserved Domains (1) summary
    pfam00001
    Location:48297
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. NM_005291.3NP_005282.1  uracil nucleotide/cysteinyl leukotriene receptor isoform a

    See identical proteins and their annotated locations for NP_005282.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC039595, DA390892, Y12546
    Consensus CDS
    CCDS2148.1
    UniProtKB/Swiss-Prot
    A8K9L0, B2R9X0, Q13304, Q8N5S7, Q9UDZ6, Q9UE21
    UniProtKB/TrEMBL
    B3KX68
    Related
    ENSP00000272644.3, ENST00000272644.7
    Conserved Domains (1) summary
    cd15161
    Location:60336
    7tmA_GPR17; G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    127646153..127652639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    128081407..128087893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)