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GPR17 G protein-coupled receptor 17 [ Homo sapiens (human) ]

Gene ID: 2840, updated on 6-Sep-2021

Summary

Official Symbol
GPR17provided by HGNC
Official Full Name
G protein-coupled receptor 17provided by HGNC
Primary source
HGNC:HGNC:4471
See related
Ensembl:ENSG00000144230 MIM:603071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 16.2), endometrium (RPKM 2.8) and 5 other tissues See more
Orthologs
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Genomic context

See GPR17 in Genome Data Viewer
Location:
2q14.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (127646153..127652639)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128403728..128410213)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373609 Neighboring gene myosin VIIB Neighboring gene uncharacterized LOC101927834 Neighboring gene LIM zinc finger domain containing 2 Neighboring gene SFT2 domain containing 3 Neighboring gene WD repeat domain 33 Neighboring gene RNY4 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686M18273

General protein information

Preferred Names
uracil nucleotide/cysteinyl leukotriene receptor
Names
P2Y-like receptor
R12
UDP/CysLT receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161415.2NP_001154887.1  uracil nucleotide/cysteinyl leukotriene receptor isoform a

    See identical proteins and their annotated locations for NP_001154887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC039595, DA314295, DA366480
    Consensus CDS
    CCDS2148.1
    UniProtKB/Swiss-Prot
    Q13304
    Related
    ENSP00000442982.1, ENST00000544369.5
    Conserved Domains (1) summary
    pfam00001
    Location:76325
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001161416.2NP_001154888.1  uracil nucleotide/cysteinyl leukotriene receptor isoform b

    See identical proteins and their annotated locations for NP_001154888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    BC039595, DA366480
    UniProtKB/Swiss-Prot
    Q13304
    UniProtKB/TrEMBL
    G4XH68
    Conserved Domains (1) summary
    pfam00001
    Location:48297
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_001161417.2NP_001154889.1  uracil nucleotide/cysteinyl leukotriene receptor isoform b

    See identical proteins and their annotated locations for NP_001154889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AK292725, BC039595
    UniProtKB/Swiss-Prot
    Q13304
    UniProtKB/TrEMBL
    G4XH68
    Related
    ENSP00000508383.1, ENST00000486700.2
    Conserved Domains (1) summary
    pfam00001
    Location:48297
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. NM_005291.3NP_005282.1  uracil nucleotide/cysteinyl leukotriene receptor isoform a

    See identical proteins and their annotated locations for NP_005282.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC039595, DA390892, Y12546
    Consensus CDS
    CCDS2148.1
    UniProtKB/Swiss-Prot
    Q13304
    Related
    ENSP00000272644.3, ENST00000272644.7
    Conserved Domains (1) summary
    pfam00001
    Location:76325
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    127646153..127652639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003833.2XP_016859322.1  uracil nucleotide/cysteinyl leukotriene receptor isoform X1

    UniProtKB/Swiss-Prot
    Q13304
    Related
    ENSP00000376741.3, ENST00000393018.3
    Conserved Domains (1) summary
    pfam00001
    Location:76325
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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