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NPW neuropeptide W [ Homo sapiens (human) ]

Gene ID: 283869, updated on 13-May-2022

Summary

Official Symbol
NPWprovided by HGNC
Official Full Name
neuropeptide Wprovided by HGNC
Primary source
HGNC:HGNC:30509
See related
Ensembl:ENSG00000183971 MIM:607997; AllianceGenome:HGNC:30509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L8; L8C; PPL8; PPNPW
Summary
The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 2.8), stomach (RPKM 0.8) and 1 other tissue See more
Orthologs
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Genomic context

See NPW in Genome Data Viewer
Location:
16p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2019785..2020755)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2039738..2040709)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2069786..2070756)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903626 Neighboring gene RNA, 7SL, cytoplasmic 219, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr16.496 Neighboring gene NHERF family PDZ scaffold protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in feeding behavior IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuropeptide W
Names
hPPL8
prepro-neuropeptide W
preproprotein L8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099456.3NP_001092926.2  neuropeptide W preproprotein

    See identical proteins and their annotated locations for NP_001092926.2

    Status: REVIEWED

    Source sequence(s)
    AB084276, BM985063
    Consensus CDS
    CCDS42102.1
    UniProtKB/Swiss-Prot
    Q8N729
    Related
    ENSP00000456974.3, ENST00000566435.4
    Conserved Domains (1) summary
    pfam15180
    Location:30113
    NPBW; Neuropeptides B and W

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2019785..2020755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791799.1 Reference GRCh38.p14 PATCHES

    Range
    85929..86899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2039738..2040709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)