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FBXL22 F-box and leucine rich repeat protein 22 [ Homo sapiens (human) ]

Gene ID: 283807, updated on 23-Nov-2021

Summary

Official Symbol
FBXL22provided by HGNC
Official Full Name
F-box and leucine rich repeat protein 22provided by HGNC
Primary source
HGNC:HGNC:27537
See related
Ensembl:ENSG00000197361 MIM:609088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbl22
Summary
This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]
Expression
Broad expression in endometrium (RPKM 6.9), prostate (RPKM 3.6) and 21 other tissues See more
Orthologs
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Genomic context

See FBXL22 in Genome Data Viewer
Location:
15q22.31
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (63597387..63603432)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (63889586..63895631)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2568 Neighboring gene ubiquitin specific peptidase 3 Neighboring gene USP3 antisense RNA 1 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene microRNA 422a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39626, MGC75496

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
F-box and leucine-rich protein 22
Names
F-box/LRR-repeat protein 22
NP_001354736.1
NP_001354737.1
NP_001354738.1
NP_976307.2
XP_006720541.1
XP_011519770.1
XP_011519771.1
XP_011519774.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027784.1 RefSeqGene

    Range
    5035..11080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001367807.1NP_001354736.1  F-box and leucine-rich protein 22 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC118274
    Related
    ENSP00000492359.1, ENST00000638704.2
    Conserved Domains (3) summary
    cd09293
    Location:113200
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:122147
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:949
    F-box-like
  2. NM_001367808.1NP_001354737.1  F-box and leucine-rich protein 22 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC118274, AK096945
    Related
    ENSP00000453697.2, ENST00000534939.2
    Conserved Domains (1) summary
    pfam12937
    Location:949
    F-box-like
  3. NM_001367809.1NP_001354738.1  F-box and leucine-rich protein 22 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC118274
    Conserved Domains (1) summary
    pfam12937
    Location:949
    F-box-like
  4. NM_203373.3NP_976307.2  F-box and leucine-rich protein 22 isoform 1

    See identical proteins and their annotated locations for NP_976307.2

    Status: REVIEWED

    Source sequence(s)
    AA495872, AC118274, BC065833
    Consensus CDS
    CCDS10187.2
    UniProtKB/Swiss-Prot
    Q6P050
    Related
    ENSP00000353794.3, ENST00000360587.2
    Conserved Domains (1) summary
    pfam12937
    Location:955
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    63597387..63603432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521468.3XP_011519770.1  F-box and leucine-rich protein 22 isoform X1

    See identical proteins and their annotated locations for XP_011519770.1

    Conserved Domains (2) summary
    cd09293
    Location:148229
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:151176
    LRR_AMN1; leucine-rich repeat [structural motif]
  2. XM_011521472.3XP_011519774.1  F-box and leucine-rich protein 22 isoform X3

    See identical proteins and their annotated locations for XP_011519774.1

    Conserved Domains (2) summary
    cd09293
    Location:992
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:1439
    LRR_AMN1; leucine-rich repeat [structural motif]
  3. XM_011521469.2XP_011519771.1  F-box and leucine-rich protein 22 isoform X1

    See identical proteins and their annotated locations for XP_011519771.1

    Conserved Domains (2) summary
    cd09293
    Location:148229
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:151176
    LRR_AMN1; leucine-rich repeat [structural motif]
  4. XM_006720478.2XP_006720541.1  F-box and leucine-rich protein 22 isoform X3

    See identical proteins and their annotated locations for XP_006720541.1

    Conserved Domains (2) summary
    cd09293
    Location:992
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:1439
    LRR_AMN1; leucine-rich repeat [structural motif]
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