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KCNRG potassium channel regulator [ Homo sapiens (human) ]

Gene ID: 283518, updated on 5-Jan-2022

Summary

Official Symbol
KCNRGprovided by HGNC
Official Full Name
potassium channel regulatorprovided by HGNC
Primary source
HGNC:HGNC:18893
See related
Ensembl:ENSG00000198553 MIM:607947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLTET
Summary
This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Expression
Broad expression in testis (RPKM 38.4), bone marrow (RPKM 16.2) and 24 other tissues See more
Orthologs
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Genomic context

See KCNRG in Genome Data Viewer
Location:
13q14.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (50015444..50020922)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50589580..50595058)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene SPRY domain containing 7 Neighboring gene deleted in lymphocytic leukemia 2 Neighboring gene microRNA 3613 Neighboring gene tripartite motif containing 13 Neighboring gene microRNA 16-1 Neighboring gene microRNA 15a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
potassium channel regulatory protein
Names
putative potassium channel regulatory protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173605.2NP_775876.1  potassium channel regulatory protein isoform 1

    See identical proteins and their annotated locations for NP_775876.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the shorter transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AY169388
    Consensus CDS
    CCDS9424.1
    UniProtKB/Swiss-Prot
    Q8N5I3
    Related
    ENSP00000324191.1, ENST00000312942.2
    Conserved Domains (1) summary
    cl02518
    Location:794
    BTB; BTB/POZ domain
  2. NM_199464.3NP_955751.1  potassium channel regulatory protein isoform 2

    See identical proteins and their annotated locations for NP_955751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon which results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AY169387, BX116021
    Consensus CDS
    CCDS41889.1
    UniProtKB/Swiss-Prot
    Q8N5I3
    Related
    ENSP00000353661.4, ENST00000360473.8
    Conserved Domains (2) summary
    smart00225
    Location:7104
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cl02518
    Location:794
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    50015444..50020922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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