Format

Send to:

Choose Destination

GATC glutamyl-tRNA amidotransferase subunit C [ Homo sapiens (human) ]

Gene ID: 283459, updated on 5-Aug-2018

Summary

Official Symbol
GATCprovided by HGNC
Official Full Name
glutamyl-tRNA amidotransferase subunit Cprovided by HGNC
Primary source
HGNC:HGNC:25068
See related
Ensembl:ENSG00000257218 MIM:617210; Vega:OTTHUMG00000047788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
15E1.2
Expression
Ubiquitous expression in thyroid (RPKM 15.5), lymph node (RPKM 14.0) and 25 other tissues See more
Orthologs

Genomic context

See GATC in Genome Data Viewer
Location:
12q24.31
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (120446438..120463753)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120884241..120901556)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6A1 Neighboring gene TP53 regulated inhibitor of apoptosis 1 Neighboring gene ribosomal protein L31 pseudogene 52 Neighboring gene serine and arginine rich splicing factor 9 Neighboring gene dynein light chain LC8-type 1 Neighboring gene uncharacterized LOC107987181 Neighboring gene negative regulator of antiviral response Neighboring gene coenzyme Q5, methyltransferase Neighboring gene ribosomal protein L29 pseudogene 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: COX6A1

Homology

Clone Names

  • FLJ37000, MGC129938

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
glutaminyl-tRNAGln biosynthesis via transamidation IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translational fidelity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
glutamyl-tRNA(Gln) amidotransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
Names
glu-AdT subunit C
glutamyl-tRNA(Gln) amidotransferase, subunit C homolog
NP_789788.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176818.2NP_789788.1  glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

    See identical proteins and their annotated locations for NP_789788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript.
    Source sequence(s)
    AL021546, BC107145
    Consensus CDS
    CCDS31911.1
    UniProtKB/Swiss-Prot
    O43716
    Related
    ENSP00000446872.1, OTTHUMP00000045454, ENST00000551765.5, OTTHUMT00000108981
    Conserved Domains (1) summary
    PRK00034
    Location:31118
    gatC; aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed

RNA

  1. NR_033684.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional coding exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon as used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL021546, BC047778

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    120446438..120463753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center