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PRLHR prolactin releasing hormone receptor [ Homo sapiens (human) ]

Gene ID: 2834, updated on 17-Jun-2024

Summary

Official Symbol
PRLHRprovided by HGNC
Official Full Name
prolactin releasing hormone receptorprovided by HGNC
Primary source
HGNC:HGNC:4464
See related
Ensembl:ENSG00000119973 MIM:600895; AllianceGenome:HGNC:4464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GR3; GPR10; PrRPR
Summary
Predicted to enable neuropeptide receptor activity. Predicted to be involved in female pregnancy. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; feeding behavior; and hormone metabolic process. Located in cilium. Implicated in hypertension. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal (RPKM 3.6), endometrium (RPKM 1.7) and 1 other tissue See more
Orthologs
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Genomic context

See PRLHR in Genome Data Viewer
Location:
10q26.11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (118589997..118595648, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (119485136..119490787, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120349509..120355160, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378507 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:120289267-120289465 Neighboring gene solute carrier family 25 member 18 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:120344096-120345295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120354119-120354927 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120354928-120355736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120355737-120356545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120394958-120395458 Neighboring gene TOMM22 pseudogene 5 Neighboring gene CDK2 associated cullin domain 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4103

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC126539, MGC126541

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy TAS
Traceable Author Statement
more info
PubMed 
involved_in hormone metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prolactin-releasing peptide receptor
Names
G-protein coupled receptor 10
hGR3
prRP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004248.3NP_004239.2  prolactin-releasing peptide receptor

    Status: VALIDATED

    Source sequence(s)
    AL356865
    Consensus CDS
    CCDS7606.1
    UniProtKB/Swiss-Prot
    O75194, P49683, Q502U8, Q5VXR9
    UniProtKB/TrEMBL
    A5JUU5
    Related
    ENSP00000239032.2, ENST00000239032.4
    Conserved Domains (1) summary
    cd15394
    Location:77346
    7tmA_PrRP_R; prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    118589997..118595648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    119485136..119490787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)