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PRLHR prolactin releasing hormone receptor [ Homo sapiens (human) ]

Gene ID: 2834, updated on 1-Jun-2020

Summary

Official Symbol
PRLHRprovided by HGNC
Official Full Name
prolactin releasing hormone receptorprovided by HGNC
Primary source
HGNC:HGNC:4464
See related
Ensembl:ENSG00000119973 MIM:600895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GR3; GPR10; PrRPR
Summary
PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in adrenal (RPKM 3.6), endometrium (RPKM 1.7) and 1 other tissue See more
Orthologs

Genomic context

See PRLHR in Genome Data Viewer
Location:
10q26.11
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (118589997..118595648, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120352916..120355160, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378507 Neighboring gene solute carrier family 25 member 18 pseudogene 1 Neighboring gene TOMM22 pseudogene 5 Neighboring gene CDK2 associated cullin domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126539, MGC126541

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
 
neuropeptide receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adult feeding behavior IEA
Inferred from Electronic Annotation
more info
 
female pregnancy TAS
Traceable Author Statement
more info
PubMed 
hormone metabolic process IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
9+0 non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
glial cell projection IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prolactin-releasing peptide receptor
Names
G-protein coupled receptor 10
hGR3
prRP receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004248.3NP_004239.2  prolactin-releasing peptide receptor

    Status: VALIDATED

    Source sequence(s)
    AL356865
    Consensus CDS
    CCDS7606.1
    Related
    ENSP00000239032.2, ENST00000239032.4
    Conserved Domains (1) summary
    cd15394
    Location:77346
    7tmA_PrRP_R; prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    118589997..118595648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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