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IGSF22 immunoglobulin superfamily member 22 [ Homo sapiens (human) ]

Gene ID: 283284, updated on 9-Sep-2018

Summary

Official Symbol
IGSF22provided by HGNC
Official Full Name
immunoglobulin superfamily member 22provided by HGNC
Primary source
HGNC:HGNC:26750
See related
Ensembl:ENSG00000179057 Vega:OTTHUMG00000160502
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGFN2
Expression
Broad expression in kidney (RPKM 2.8), skin (RPKM 1.7) and 21 other tissues See more
Orthologs

Genomic context

See IGSF22 in Genome Data Viewer
Location:
11p15.1
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (18704305..18726939, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18725852..18747777, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376578 Neighboring gene serine and arginine rich splicing factor 3 pseudogene Neighboring gene uncharacterized LOC105376579 Neighboring gene transmembrane protein 86A Neighboring gene protein tyrosine phosphatase, non-receptor type 5 Neighboring gene MAS related GPR family member X2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

General gene information

Markers

Homology

Clone Names

  • FLJ37794

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle alpha-actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cardiac muscle fiber development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cardiac muscle tissue morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cardiac myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
skeletal muscle myosin thick filament assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
skeletal muscle thin filament assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
M band IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Z disc IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcomere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
immunoglobulin superfamily member 22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173588.3NP_775859.3  immunoglobulin superfamily member 22

    Status: VALIDATED

    Source sequence(s)
    AA255875, AC103974, AI952274, AK095113, BC115396, BC115397
    Consensus CDS
    CCDS41625.2
    UniProtKB/Swiss-Prot
    Q8N9C0
    Related
    ENSP00000421191.1, OTTHUMP00000218334, ENST00000513874.5, OTTHUMT00000360850
    Conserved Domains (6) summary
    cd00096
    Location:436492
    Ig; Immunoglobulin domain
    cd05748
    Location:627697
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00410
    Location:617697
    IG_like; Immunoglobulin like
    cd00063
    Location:802892
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:12131302
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:12361302
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    18704305..18726939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017607.1XP_016873096.1  immunoglobulin superfamily member 22 isoform X1

    Conserved Domains (6) summary
    cd00096
    Location:456512
    Ig; Immunoglobulin domain
    cd05748
    Location:647717
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00410
    Location:637717
    IG_like; Immunoglobulin like
    cd00063
    Location:822912
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:12331322
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:12561322
    Ig; Immunoglobulin domain
  2. XM_017017608.1XP_016873097.1  immunoglobulin superfamily member 22 isoform X3

    UniProtKB/Swiss-Prot
    Q8N9C0
  3. XM_011520031.2XP_011518333.1  immunoglobulin superfamily member 22 isoform X2

    Conserved Domains (6) summary
    cd00096
    Location:456512
    Ig; Immunoglobulin domain
    cd05748
    Location:647717
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00410
    Location:637717
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:11321221
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:11551221
    Ig; Immunoglobulin domain
  4. XM_011520030.2XP_011518332.1  immunoglobulin superfamily member 22 isoform X1

    Conserved Domains (6) summary
    cd00096
    Location:456512
    Ig; Immunoglobulin domain
    cd05748
    Location:647717
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00410
    Location:637717
    IG_like; Immunoglobulin like
    cd00063
    Location:822912
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:12331322
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:12561322
    Ig; Immunoglobulin domain
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