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SLC22A24 solute carrier family 22 member 24 [ Homo sapiens (human) ]

Gene ID: 283238, updated on 12-Oct-2019

Summary

Official Symbol
SLC22A24provided by HGNC
Official Full Name
solute carrier family 22 member 24provided by HGNC
Primary source
HGNC:HGNC:28542
See related
Ensembl:ENSG00000197658 MIM:611698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET46
Summary
SLC22A24 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See SLC22A24 in Genome Data Viewer
Location:
11q12.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (63079940..63144221, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62847412..62911693, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene PTTG1 regulator of sister chromatid separation, securin pseudogene Neighboring gene tubulin alpha 4a pseudogene Neighboring gene ribosomal protein L29 pseudogene 22 Neighboring gene solute carrier family 22 member 25 Neighboring gene uncharacterized LOC105369334 Neighboring gene cyclin D2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of maternal and inherited loci for conotruncal heart defects.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34821

Gene Ontology Provided by GOA

Process Evidence Code Pubs
organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 22 member 24

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136506.2NP_001129978.2  solute carrier family 22 member 24 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP001858, KF459672
    Consensus CDS
    CCDS73308.1
    UniProtKB/TrEMBL
    A0A087WWM3
    Related
    ENSP00000480336.1, ENST00000612278.4
    Conserved Domains (2) summary
    cd06174
    Location:125516
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11526
    2A0119; cation transport protein
  2. NM_173586.3NP_775857.2  solute carrier family 22 member 24 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AP001858, BC034394
    Consensus CDS
    CCDS76422.1
    UniProtKB/Swiss-Prot
    Q8N4F4
    Related
    ENSP00000321549.5, ENST00000326192.5
    Conserved Domains (1) summary
    cd06174
    Location:125278
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    63079940..63144221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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