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NPBWR2 neuropeptides B and W receptor 2 [ Homo sapiens (human) ]

Gene ID: 2832, updated on 13-May-2022

Summary

Official Symbol
NPBWR2provided by HGNC
Official Full Name
neuropeptides B and W receptor 2provided by HGNC
Primary source
HGNC:HGNC:4530
See related
Ensembl:ENSG00000125522 MIM:600731; AllianceGenome:HGNC:4530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR8
Summary
The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See NPBWR2 in Genome Data Viewer
Location:
20q13.33
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (64103802..64107565, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65925944..65929663, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62735155..62738918, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene regulator of G protein signaling 19 Neighboring gene microRNA 6813 Neighboring gene opioid related nociceptin receptor 1 Neighboring gene LKAAEAR motif containing 1 Neighboring gene Sharpr-MPRA regulatory region 6051 Neighboring gene B6.7 minisatellite repeat instability region

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled opioid receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IC
Inferred by Curator
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuropeptides B/W receptor type 2
Names
G-protein coupled receptor 8
neuropeptides B/W receptor 2
opioid-somatostatin-like receptor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005286.4NP_005277.2  neuropeptides B/W receptor type 2

    See identical proteins and their annotated locations for NP_005277.2

    Status: REVIEWED

    Source sequence(s)
    AL121581
    Consensus CDS
    CCDS13557.1
    UniProtKB/Swiss-Prot
    P48146
    Related
    ENSP00000508236.1, ENST00000684052.1
    Conserved Domains (1) summary
    cd15087
    Location:46327
    7tmA_NPBWR; neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    64103802..64107565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187624.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    8748..12511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65925944..65929663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)